Kavli Affiliate: Michael Shadlen | Authors: Shinichiro Kira, Ariel Zylberberg and Michael N Shadlen | Summary: Abstract Many decisions benefit from the accumulation of evidence obtained sequentially over time. In such circumstances, the decision maker must balance speed against accuracy, and the nature of this tradeoff mediates competing desiderata and costs, especially those associated with […]
Kavli Affiliate: Rafael Yuste | Authors: Netanel Ofer, Victor Hugo Cornejo and Rafael Yuste | Summary: Abstract The propagation of action potentials along axons is traditionally considered to be reliable, as a consequence of the high safety factor of action potential propagation. However, numerical simulations have suggested that, at high frequencies, spikes could fail to […]
Kavli Affiliate: Rafael Yuste | Authors: Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A O’Neil, Fabian J Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck, Michael Wenzel and Tony Kelly | Summary: Abstract Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using […]
Kavli Affiliate: Darcy Peterka | Authors: Robert M. Lees, Isaac H. Bianco, Robert A. A. Campbell, Natalia Orlova, Darcy S. Peterka, Bruno Pichler, Spencer LaVere Smith, Dimitri Yatsenko, Che-Hang Yu and Adam M. Packer | Summary: Abstract The goal of this protocol is to enable better characterisation of multiphoton microscopy hardware across a large user […]
Kavli Affiliate: Kenneth Miller | Authors: Serena Di Santo, Mario Dipoppa, Andreas Keller, Morgane Roth, Massimo Scanziani and Kenneth D Miller | Summary: Abstract Sensory systems must combine local features with context to infer meaning. Accordingly, context profoundly influences neural responses. We developed a unified circuit model demonstrating how feedforward and feedback inputs are integrated […]
Kavli Affiliate: Daphna Shohamy and Michael Shadlen | Authors: Ariel Zylberberg, Akram Bakkour, Daphna Shohamy and Michael N Shadlen | Summary: Many decisions are expressed as a preference for one item over another. When these items are familiar, it is often assumed that the decision maker assigns a value to each of the items and […]
Kavli Affiliate: Elizabeth Hillman, Mark Ellisman and Darcy Peterka | Authors: Alexander R. Goldberg, Athanassios Dovas, Daniela Torres, Sohani Das Sharma, Angeliki Mela, Edward M. Merricks, Markel Olabarria, Leila Abrishami Shokoohm, Hanzhi T. Zhao, Corina Kotidis, Peter Calvaresi, Ashwin Viswanathan, Matei A. Banu, Aida Razavilar, Tejaswi D. Sudhakar, Ankita Saxena, Cole Chokran, Nelson Humala, Aayushi […]
Kavli Affiliate: Michael Goldberg | Authors: Michael E Goldberg, Michelle D Noyes, Evan E Eichler, Aaron Quinlan and Kelley Harris | Summary: Short tandem repeats (STRs) are hotspots of genomic variability in the human germline because of their high mutation rates, which have long been attributed largely to polymerase slippage during DNA replication. This model […]
Kavli Affiliate: Kenneth Miller | Authors: Ji Xia, Anna Jasper, Adam Kohn and Kenneth D Miller | Summary: Correlated variability in the visual cortex is modulated by stimulus properties. The stimulus dependence of correlated variability impacts stimulus coding and is indicative of circuit structure. An affine model combining a factor proportional to mean stimulus response […]
Kavli Affiliate: Stefano Fusi & Daniel Salzman | Authors: Hristos Spiridonos Courellis, Juri Minxha, Araceli Ramirez Cardenas, Daniel L Kimmel, Chrystal M Reed, Taufik A Valiante, C. Daniel Salzman, Adam N Mamelak, Ralph Adolphs, Stefano Fusi and Ueli Rutishauser | Summary: Humans have the remarkable cognitive capacity to rapidly adapt to changing environments. Central to […]