Kavli Affiliate: Rui Costa | Authors: Martha G Garcia-Garcia, Michal Jozef Wojcik, Srijan Thota, Luke Drake, Amma Otchere, Oluwatobi Akinwale, Lizmaylin Ramos, Rui Ponte Costa and Mark J Wagner | Summary: To learn effectively, animals must generalize across yet distinguish between related contexts. Generalization relies on low-dimensional neural manifolds found throughout neocortex1,2, which accelerate learning […]
Kavli Affiliate: Michael Shadlen | Authors: Sriram Thothathri, Bharath Chandra Talluri, S. Shushruth, Michael N. Shadlen and Hendrikje Nienborg | Summary: Perception and action form a loop as an organism interacts with its environment. Here, we probe the interdependence between the two in the context of choice-history effects, the tendency of past choices and their […]
Kavli Affiliate: Wei Min | Authors: Xinwen Liu, Xuemeng Li, Lele Xu, Mian Wei, Areej Niaz, Ye He and Wei Min | Summary: Molecular information is vital for imaging technology. Optical imaging acquires molecular specificity almost exclusively via labeling strategy, which is fundamentally constrained by limited multiplexing capacity, high running costs, and experimental complexity. Conversely, […]
Kavli Affiliate: Wei Min | Authors: Alexander-Hoi Nguyen, Vicky Li, Wei-Min Chen, Jacob Kimberg, Anthony J. Davis, David G. McFadden and Juan Manuel Povedano | Summary: DNA mismatch repair (MMR) deficiency has been widely utilized in forward genetic screens to identify drug resistance mutations and elucidate the mechanisms of action of cytotoxic small molecules. However, […]
Kavli Affiliate: Michael Shadlen | Authors: Ariel Zylberberg, Ian Krajbich and Michael N Shadlen | Summary: Attention plays a key role in decision-making by directing limited cognitive resources to relevant information. It has been proposed that attention also biases the decision process, due to a multiplicative interaction between attention and subjective value (e.g., Krajbich et […]
Kavli Affiliate: Darcy Peterka | Authors: Chloe L West, Fumiyasu Imai, Georgia Bastos, Molly Hornick, Lital Rachmany, Annabel Duran, Samen Nadeem, David A Ricci, Anna M Rader Groves, Joseph A Wargo, Neil Van Leeuwen, Henry Sershen, Vinod Yaragudri, Darcy S Peterka and Jordan P Hamm | Summary: Serotonergic psychedelics (e.g., psilocybin, LSD) have potential to […]
Kavli Affiliate: Rui Costa and Darcy Peterka | Authors: nes Rodrigues-Vaz, Vivek R. Athalye, Helio F. M. Rodrigues, Darcy S. Peterka and Rui M. Costa | Summary: The striatum is classically thought to modulate action vigor and reinforcement, but whether it specifies and controls ongoing actions at a fine scale remains unclear. Here, we test […]
Kavli Affiliate: Rui Costa and Darcy Peterka | Authors: Ines Rodrigues-Vaz, Vivek R. Athalye, Darcy S. Peterka and Rui M. Costa | Summary: The striatum is classically thought to modulate action vigor and reinforcement, but whether it specifies and controls ongoing actions at a fine scale remains unclear. Here, we test whether striatal activity can […]
Kavli Affiliate: Rafael Yuste | Authors: Dean Geckt, Netanel Ofer, Michael W. Reimann, Rafael Yuste and Idan Segev | Summary: Dendritic spines, small protrusions covering the dendrites of most neurons, are fundamental elements of synaptic connectivity, yet their network-level organization remains poorly understood. Here we leverage the large-scale MICrONS volumetric electron microscopy dataset of mouse […]
Kavli Affiliate: Rui Costa | Authors: Michael Pereira, Beatriz S. Godinho, Christian K. Machens, Rui M. Costa and Thomas Akam | Summary: Action selection using predictive models of the environment plays a fundamental role in human and animal behaviour, yet is poorly understood at circuit and algorithmic levels. Spatial navigation is an attractive domain for […]