HTRA1 deficiency in COL4A1 mutant hiPSC-derived astrocytes, a convergent mechanism of cerebral small vessel disease

Kavli Affiliate: Zameel Cader | Authors: Xuewei Qi, Alessandra Granata, Tom Van Agtmael, Sanjay Sinha, Zameel Cader, Hugh S Markus, Stuart M. Allan, Karen Horsburgh and Tao Wang | Summary: Cerebral small vessel disease (cSVD) is a major contributor to stroke and cognitive decline, ultimately leading to vascular dementia (VaD). Genetic factors play a key […]


Continue.. HTRA1 deficiency in COL4A1 mutant hiPSC-derived astrocytes, a convergent mechanism of cerebral small vessel disease

Magnon polaritons in a van der Waals ferromagnet coupled to a superconducting resonator

Kavli Affiliate: Herre Van Der Zant | Summary:Achieving magnon-photon hybridization in the microwave regime is essential for integrating magnetic excitations with superconducting circuits. While this has been extensively demonstrated in bulk magnetic systems, realizing it in two-dimensional van der Waals materials remains challenging due to their reduced magnetic volume and increased dissipation. Here, magnon-photon hybridization […]


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Metal Saturation and the Redistribution of Hydrogen in Earth’s Mantle

Kavli Affiliate: Paul D. Asimow | Summary:Iron disproportionation reactions in mantle silicates can produce metallic iron that drives Earth’s deep mantle toward metal saturation under reduced conditions. Subducting slabs transport hydrated silicates to these depths, where interactions with metallic iron can reduce structurally bound hydrogen in silicates to reduced hydrogen-bearing phases, such as molecular hydrogen […]


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A Uniform Determination of the Bulk Metallicities and Alpha Enrichments of Confirmed Exoplanet Systems with TRES

Kavli Affiliate: David Charbonneau | Summary:We present a uniform spectroscopic characterization of 625 F, G, and K stars hosting 859 confirmed exoplanets using high-resolution archival optical spectra from the Tillinghast Reflector Echelle Spectrograph (TRES). We use the neural network spectral code uberMS, which combines spectra with broadband photometry to estimate precise and accurate stellar parameters. […]


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Uncovering and Shaping the Latent Representation of 3D Scene Topology in Vision-Language Models

Kavli Affiliate: Wei Gao| Summary:Decades of cognitive science establish that humans navigate environments by forming cognitive maps, defined as allocentric and topology-preserving representations of 3D space. While modern Vision-Language Models (VLMs) demonstrate emergent spatial reasoning from 2D egocentric inputs, it remains unclear whether they construct an analogous 3D internal representation. In this paper, we demonstrate […]


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Colossal Magnetoresistance and Phonon Driven Exchange Dynamics in Eu$_5$Sn$_2$As$_6$

Kavli Affiliate: Joel Moore | Summary:The emergence of colossal magnetoresistance in a new generation of Eu$^2+$-based antiferromagnets is intriguing given stark contrasts to the archetypal perovskite manganites and doped Eu-chalcogenides. In this study the thermal conductivity and magnetostriction of Eu$_5$Sn$_2$As$_6$ — one such representative — have been measured to better understand the role of the […]


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Electrically controlled Heat Assisted Magnetic Recording in Intercalated 2D Magnets

Kavli Affiliate: James Analytis| Summary:The ever-increasing demand for fast, reliable, and energy-efficient information storage continues to push magnetic memory technologies toward their fundamental limits. Conventional scaling strategies, which rely on reducing bit size, inevitably run into the "magnetic recording trilemma," where signal-to-noise ratio, thermal stability, and writability cannot all be optimized simultaneously. Heat-assisted magnetic recording […]


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ReActor: Reinforcement Learning for Physics-Aware Motion Retargeting

Kavli Affiliate: David Muller | Summary:Retargeting human kinematic reference motion onto a robot’s morphology remains a formidable challenge. Existing methods often produce physical inconsistencies, such as foot sliding, self-collisions, or dynamically infeasible motions, which hinder downstream imitation learning. We propose a bilevel optimization framework that jointly adapts reference motions to a robot’s morphology while training […]


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ROSE: Rollout On Serving GPUs via Cooperative Elasticity for Agentic RL

Kavli Affiliate: Wei Gao| Summary:Agentic reinforcement learning (RL) has emerged as a key driver for improving the multi-step reasoning and tool-use capabilities of LLMs. However, its efficiency is bottlenecked by long-tail rollouts with multi-turn environment interactions, making static GPU provisioning a poor fit: overprovisioning wastes GPUs on stragglers, while underprovisioning increases contention and slows training. […]


Continue.. ROSE: Rollout On Serving GPUs via Cooperative Elasticity for Agentic RL

ROSE: Rollout On Serving GPUs via Cooperative Elasticity for Agentic RL

Kavli Affiliate: Wei Gao| Summary:Agentic reinforcement learning (RL) is reshaping LLM post-training, but end-to-end training time is dominated by compute-intensive, multi-turn rollouts whose resource demand varies significantly across training steps. Resource-fixed systems cannot adapt to this variation, while resource-elastic approaches that provision external GPUs on demand suffer from high allocation overhead and limited availability. We […]


Continue.. ROSE: Rollout On Serving GPUs via Cooperative Elasticity for Agentic RL