Continuous symmetry breaking in adaptive quantum dynamics

Kavli Affiliate: Matthew P. A. Fisher | First 5 Authors: Jacob Hauser, Yaodong Li, Sagar Vijay, Matthew P. A. Fisher | Summary: Adaptive quantum circuits, in which unitary operations, measurements, and feedback are used to steer quantum many-body systems, provide an exciting opportunity to generate new dynamical steady states. We introduce an adaptive quantum dynamics […]


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3D structural human interactome reveals proteome-wide perturbations by disease mutations

Kavli Affiliate: Jin Kang | Authors: Dapeng Xiong, Junfei Zhao, Yunguang Qiu, Yadi Zhou, Dongjin Lee, Shobhita Gupta, Weiqiang Lu, Siqi Liang, Jin Joo Kang, Charis Eng, Joseph Loscalzo, Feixiong Cheng and Haiyuan Yu | Summary: Human genome sequencing studies have identified numerous loci associated with complex diseases. However, translating human genetic and genomic findings […]


Continue.. 3D structural human interactome reveals proteome-wide perturbations by disease mutations

Spin-polarons and ferromagnetism in doped dilute Wigner-Mott insulators

Kavli Affiliate: Leon Balents | First 5 Authors: Urban F. P. Seifert, Leon Balents | Summary: Moir’e heterostructures of transition metal dichalcogenides exhibit Mott-insulating behaviour both at half-filling as well as at fractional fillings, where electronic degrees of freedom form self-organized Wigner crystal states. An open question concerns magnetic states obtained by lifting the pseudospin-1/2 […]


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On the mechanism of polaritonic rate suppression from quantum transition paths

Kavli Affiliate: David T. Limmer | First 5 Authors: Michelle C. Anderson, Esmae J. Woods, Thomas P. Fay, David J. Wales, David T. Limmer | Summary: Polariton chemistry holds promise for facilitating mode-selective chemical reactions, but the underlying mechanism behind the rate modifications observed under vibrational strong coupling is not well understood. Using the recently […]


Continue.. On the mechanism of polaritonic rate suppression from quantum transition paths

On the mechanism of polaritonic rate suppression from quantum transition paths

Kavli Affiliate: David T. Limmer | First 5 Authors: Michelle C. Anderson, Esmae J. Woods, Thomas P. Fay, David J. Wales, David T. Limmer | Summary: Polariton chemistry holds promise for facilitating mode-selective chemical reactions, but the underlying mechanism behind the rate modifications observed under vibrational strong coupling is not well understood. Using the recently […]


Continue.. On the mechanism of polaritonic rate suppression from quantum transition paths

On the mechanism of polaritonic rate suppression from quantum transition paths

Kavli Affiliate: David T. Limmer | First 5 Authors: Michelle C. Anderson, Esmae J. Woods, Thomas P. Fay, David J. Wales, David T. Limmer | Summary: Polariton chemistry holds promise for facilitating mode-selective chemical reactions, but the underlying mechanism behind the rate modifications observed under vibrational strong coupling is not well understood. Using the recently […]


Continue.. On the mechanism of polaritonic rate suppression from quantum transition paths

Layer 5a Corticostriatal Projection Neurons are Selectively Vulnerable in Huntington’s Disease

Kavli Affiliate: Nathaniel Heintz | Authors: Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Alison R Weiss, William Liguore, Thomas Carroll, David A Davis, Jodi McBride and Nathaniel Heintz | Summary: The properties of the cell types that are most vulnerable in the Huntington’s disease (HD) cortex, the nature of somatic CAG expansion […]


Continue.. Layer 5a Corticostriatal Projection Neurons are Selectively Vulnerable in Huntington’s Disease

Cell Type Specific CAG Repeat Expansion and Toxicity of Mutant Huntingtin in Human Striatal and Cerebellar Cell Types

Kavli Affiliate: Nathaniel Heintz | Authors: Kert Mätlik, Matthew Baffuto, Laura Kus, David A Davis, Matthew R Paul, Thomas S Carroll and Nathaniel Heintz | Summary: Tissue-specific somatic expansion of the mutant Huntingtin (mHTT) CAG tract and regional degeneration of the brain are key features of Huntington’s disease (HD). However, the relationships between somatic CAG […]


Continue.. Cell Type Specific CAG Repeat Expansion and Toxicity of Mutant Huntingtin in Human Striatal and Cerebellar Cell Types

Insights for disease modeling from single cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Kavli Affiliate: Loyal Goff | Authors: Debamitra Das, Shreyash Sonthalia, Genevieve G Stein-O’Brien, Marah Wahbeh, Kyra Feuer, Loyal Goff, Carlo Colantuoni, Vasiliki Machairaki and Dimitrios Avramopoulos | Summary: Trans-differentiation of human induced pluripotent stem cells into neurons via Ngn2-induction (hiPSC-N) has become an efficient system to quickly generate neurons for disease modeling and in vitro […]


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A spatially resolved single cell genomic atlas of the adult human breast

Kavli Affiliate: Robert Edwards | Authors: Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei, Min Hu, Anna Casasent, Aatish Thennavan, Jianzhuo Li, Tuan Tran, Ken Chen, Benedikt Nilges, Nachiket Kashikar, Oliver Braubach, Bassem Cheikh, Nadya Nikulina, Hui Chen, Mediate Teshome, Brian Menegaz, Huma […]


Continue.. A spatially resolved single cell genomic atlas of the adult human breast