Selective Vulnerability of Layer 5a Corticostriatal Neurons in Huntington’s Disease

Kavli Affiliate: Nathaniel Heintz | Authors: Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Matthew R Paul, Alison R Weiss, William Liguore, Thomas Carroll, David A Davis, Jodi McBride and Nathaniel Heintz | Summary: The properties of the cell types that are most vulnerable in Huntington’s disease (HD) cortex, the nature of somatic […]


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Cerebellar-driven cortical dynamics enable task acquisition, switching and consolidation

Kavli Affiliate: Costa, Rui | Authors: Joseph Pemberton, Paul Chadderton and Rui Ponte Costa | Summary: Abstract To drive behavior, the cortex must bridge sensory cues with future outcomes. However, the principles by which cortical networks learn such sensory-behavioural transformations remain largely elusive. Here, we posit that the cerebellum assumes a crucial role in driving […]


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Brain state and cortical layer-specific mechanisms underlying perception at threshold

Kavli Affiliate: Anirvan Nandy, John Reynolds | Authors: Mitchell P Morton, Sachira Denagamage, Isabel J Blume, John H Reynolds, Monika P Jadi and Anirvan S Nandy | Summary: Identical stimuli can be perceived or go unnoticed across successive presentations, producing divergent behavioral outcomes despite similarities in sensory input. We sought to understand how fluctuations in […]


Continue.. Brain state and cortical layer-specific mechanisms underlying perception at threshold

A model of marmoset monkey vocal turn-taking

Kavli Affiliate: Cory Miller | Authors: Dori Grijseels, Daniella Fairbank and Cory Miller | Summary: Vocal turn-taking has been described in a diversity of species. Yet a model that captures the various processes underlying this social behavior across species has not been developed. To this end, here we recorded a large and diverse dataset of […]


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Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain science

Kavli Affiliate: Laurent Younes & Donald Geman | Authors: Kun Yang, Koko Ishizuka, Andrew P Lane, Zui Narita, Arisa Hayashida, Yukiko Y Lema, Emma Heffron, Haydn Loudd, Maeve Schumacher, Shin-ichi Kano, Toshifumi Tomoda, Atsushi Kamiya, Minghong Ma, Donald Geman, Laurent Younes and Akira Sawa | Summary: Biopsy is crucial in clinical medicine to obtain tissues […]


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Cellular Calcium Activity at Depth Predicted from Surface Potential Recordings using Ultra-high Density Transparent Graphene Arrays

Kavli Affiliate: Takaki Komiyama | Authors: Mehrdad Ramezani, Jeong-Hoon Kim, Xin Liu, Chi Ren, Abdullah Alothman, Chawina De- Eknamkul, Madison Wilson, Ertugrul Cubukcu, Vikash Gilja, Takaki Komiyama and Duygu Kuzum | Summary: Recording brain activity with high spatial and high temporal resolution across deeper layers of cortex has been a long-sought methodology to study how […]


Continue.. Cellular Calcium Activity at Depth Predicted from Surface Potential Recordings using Ultra-high Density Transparent Graphene Arrays

Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Kavli Affiliate: Jean Fan | Authors: Rafael dos Santos Peixoto, Brendan F Miller, Maigan A Brusko, Lyla Atta, Manjari Anant, Mark A Atkinson, Todd M Brusko, Clive H Wasserfall and Jean Fan | Summary: Spatially resolved omics technologies provide molecular profiling of cells while preserving their organization within tissues, allowing for the evaluation of cell-type […]


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Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals

Kavli Affiliate: Michael Beer | Authors: Jin Woo Oh and Michael A Beer | Summary: Gene regulatory elements drive many complex biological phenomena such as fetal development, and their mutations are linked to a multitude of common human diseases. The phenotypic impacts of regulatory variants are often tested using their conserved orthologous counterparts in model […]


Continue.. Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals

Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Kavli Affiliate: Michael J Higley | Authors: Samantha Bottom-Tanzer, Sofia Corella, Jochen Meyer, Mary Sommer, Luis Bolanos, Timothy Murphy, Sadi Quinones, Shane Heiney, Matthew Shtrahman, Michael Whalen, Rachel Oren, Michael J Higley, Jessica A Cardin, Farzad Noubary, Moritz Armbruster and Chris Dulla | Summary: Traumatic brain injury (TBI) is the leading cause of death in […]


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Structure-Function Coupling in Highly Sampled Individual Brains

Kavli Affiliate: Deanna J. Greene | Authors: Aishwarya Rajesh, Nicole A. Seider, Dillan J. Newbold, Babatunde Adeyemo, Scott Marek, Deanna J. Greene, Abraham Z Snyder, Joshua S. Shimony, Timothy O Laumann, Nico U.F. Dosenbach and Evan M. Gordon | Summary: Structural connections (SC) between distant regions of the brain support synchronized function known as functional […]


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