Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-typespecific vulnerabilities in human brain organoids

Posted by klaurent Hopkins

Kavli Affiliate: Jin Kang | Authors: ChangHui Pak, Rebecca Sebastian, Kang Jin, Narciso Pavon, Ruby Bansal, Andrew Potter, Yoonjae Song, Juliana Babu, Rafael Gabriel, Yubing Sun and Bruce J Aronow | Summary: De novo mutations and copy number deletions in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). It is unclear how NRXN1 deletions […]


Continue.. Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-typespecific vulnerabilities in human brain organoids

Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

Posted by klaurent Rockefeller

Kavli Affiliate: Daniel Mucida, Elaine Fuchs | Authors: Sandra Nakandakari-Higa, Maria Cecilia Campos Canesso, Sarah Walker, Aleksey Chudnovskiy, Johanne T Jacobsen, S. Martina Parigi, Karol Fiedorczuk, Elaine Fuchs, Angelina M Bilate, Giulia Pasqual, Daniel Mucida, Yuri Pritykin and Gabriel D Victora | Summary: Cellular interactions are essential for tissue organization and functionality. In particular, immune […]


Continue.. Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

Two Warm Super-Earths Transiting the Nearby M Dwarf TOI-2095

Posted by klaurent MIT

Kavli Affiliate: Roland K. Vanderspek | First 5 Authors: Elisa V. Quintana, Emily A. Gilbert, Thomas Barclay, Michele L. Silverstein, Joshua E. Schlieder | Summary: We report the detection and validation of two planets orbiting TOI-2095 (TIC 235678745). The host star is a 3700K M1V dwarf with a high proper motion. The star lies at […]


Continue.. Two Warm Super-Earths Transiting the Nearby M Dwarf TOI-2095

Two Warm Super-Earths Transiting the Nearby M Dwarf TOI-2095

Posted by klaurent MIT

Kavli Affiliate: Roland K. Vanderspek | First 5 Authors: Elisa V. Quintana, Emily A. Gilbert, Thomas Barclay, Michele L. Silverstein, Joshua E. Schlieder | Summary: We report the detection and validation of two planets orbiting TOI-2095 (TIC 235678745). The host star is a 3700K M1V dwarf with a high proper motion. The star lies at […]


Continue.. Two Warm Super-Earths Transiting the Nearby M Dwarf TOI-2095

Two Warm Super-Earths Transiting the Nearby M Dwarf TOI-2095

Posted by klaurent MIT

Kavli Affiliate: Roland K. Vanderspek | First 5 Authors: Elisa V. Quintana, Emily A. Gilbert, Thomas Barclay, Michele L. Silverstein, Joshua E. Schlieder | Summary: We report the detection and validation of two planets orbiting TOI-2095 (TIC 235678745). The host star is a 3700K M1V dwarf with a high proper motion. The star lies at […]


Continue.. Two Warm Super-Earths Transiting the Nearby M Dwarf TOI-2095

Single-test evaluation of directional elastic properties of anisotropic structured materials

Posted by klaurent Caltech

Kavli Affiliate: Chiara Daraio | First 5 Authors: Jagannadh Boddapati, Moritz Flaschel, Siddhant Kumar, Laura De Lorenzis, Chiara Daraio | Summary: When the elastic properties of structured materials become direction-dependent, the number of their descriptors increases. For example, in two-dimensions, the anisotropic behavior of materials is described by up to 6 independent elastic stiffness parameters, […]


Continue.. Single-test evaluation of directional elastic properties of anisotropic structured materials

Single-test evaluation of directional elastic properties of anisotropic structured materials

Posted by klaurent Caltech

Kavli Affiliate: Chiara Daraio | First 5 Authors: Jagannadh Boddapati, Moritz Flaschel, Siddhant Kumar, Laura De Lorenzis, Chiara Daraio | Summary: When the elastic properties of structured materials become direction-dependent, the number of their descriptors increases. For example, in two-dimensions, the anisotropic behavior of materials is described by up to 6 independent elastic stiffness parameters, […]


Continue.. Single-test evaluation of directional elastic properties of anisotropic structured materials

Single-test evaluation of directional elastic properties of anisotropic structured materials

Posted by klaurent Caltech

Kavli Affiliate: Chiara Daraio | First 5 Authors: Jagannadh Boddapati, Moritz Flaschel, Siddhant Kumar, Laura De Lorenzis, Chiara Daraio | Summary: When the elastic properties of structured materials become direction-dependent, the number of their descriptors increases. For example, in two-dimensions, the anisotropic behavior of materials is described by up to 6 independent elastic stiffness parameters, […]


Continue.. Single-test evaluation of directional elastic properties of anisotropic structured materials

TTIDA: Controllable Generative Data Augmentation via Text-to-Text and Text-to-Image Models

Posted by klaurent Berkeley

Kavli Affiliate: Xiang Zhang | First 5 Authors: Yuwei Yin, Jean Kaddour, Xiang Zhang, Yixin Nie, Zhenguang Liu | Summary: Data augmentation has been established as an efficacious approach to supplement useful information for low-resource datasets. Traditional augmentation techniques such as noise injection and image transformations have been widely used. In addition, generative data augmentation […]


Continue.. TTIDA: Controllable Generative Data Augmentation via Text-to-Text and Text-to-Image Models

Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance

Posted by klaurent Hopkins

Kavli Affiliate: Patricia Janak | Authors: Kurt M Fraser, Bridget J Chen and Patricia H Janak | Summary: Separable striatal circuits have unique functions in Pavlovian and instrumental behaviors but how these roles relate to performance of sequences of actions with and without associated cues is less clear. Here we tested whether dopamine release and […]


Continue.. Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance