Uncertainty and reward histories have distinct effects on decisions after wins and losses

Posted by dbos Hopkins

Kavli Affiliate: Patricia Janak | Shivam Kalhan, Robin Magnard, Yifeng Cheng and Patricia H. Janak | Summary: Intelligent behavior necessitates an adaptive integration of feedback. It is well-known that animals asymmetrically learn from positive and negative feedback. While asymmetrical learning is a robust behavioral effect, the latent computations behind how animals represent their environments and […]


Continue.. Uncertainty and reward histories have distinct effects on decisions after wins and losses

Neuroanatomical Basis of Coma in Acute Ischemic Stroke

Posted by dbos Rockefeller

Kavli Affiliate: Michael W. Young | Zheng Zhang, Milo White, Jennifer A Kim, Victor M Torres-Lopez, Aya Khalaf, David Jin, Aaron D Boes, Brian L Edlow, Stephen W English, David Fischer, Joel Geerling, Saleem M Halablab, Maarten G Lansberg, Margy McCullough-Hicks, James F Meschia, Patrik L Michel, Paola Palazzo, Benjamin D Reasoner, Robert W Regenhardt, […]


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Genomic resources for comparative analyses of obligate avian brood parasitism

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Rachel A Carroll, Edward Stallknecht Ricemeyer, LaDeana W Hillier, Jeffrey M DaCosta, Ekaterina Osipova, Sara Smith, Gabriel Jamie, Juan Gabriel Martinez, Mercedes Molina-Morales, Tomas Marques-Bonet, Joseph D Manthey, Diana Haddad, Matthew J Fuxjager, Kathleen S Lynch, Jonathan M.D. Wood, Erich Jarvis, Patrick Masterson, Francoise Thibaud-Nissen, Mark Hauber, Claire N […]


Continue.. Genomic resources for comparative analyses of obligate avian brood parasitism

Spatial Transcriptomics Reveal Developmental Dynamics of the Human Cerebral Cortex and Striatum

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Yunjia Zhang, Youning Lin, Xunan Shen, Xue Xiao, Cai Song, Xiaobo Shi, Tao Zhou, Yanxin Li, Zihan Wu, Zhenkun Zhuang, Chunqiong Li, Meng Li, Feng Wen, Jianlin Liu, Lei Cao, Qiangqiang Zhang, Zhao-Lu Li, Songbo Zhang, Susu Qu, Yaqi Li, Jianhua Yao, Fubaoqian Huang, Xin Liu, Ziqing Deng, Longqi […]


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Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Posted by dbos UCSF

Kavli Affiliate: Kevin Bender | Authors: Hao Wu, Luqun Shen, Jonathan Indajang, Neil K Savalia, Timothy G Johnson, Jiayin Qu, Kevin J Bender and Alex C Kwan | Summary: SCN2A is a high-confidence risk gene for autism spectrum disorder. Loss-of-function mutations in Scn2a reduce dendritic excitability in neocortical pyramidal cells. However, the impact of Scn2a […]


Continue.. Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Reconstructing Waddington’s Landscape from Data

Posted by dbos Rockefeller

Kavli Affiliate: Eric D. Siggia | Authors: Dillon J. Cislo, M Joaquina Delás, James Briscoe and Eric D. Siggia | Summary: The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attempts to exhaustively tabulate the interactions within developmental signaling networks that coordinate […]


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Accessible, realistic genome simulation with selection using stdpopsim

Posted by dbos Columbia

Kavli Affiliate: Scott Small | Authors: Graham Gower, Nathaniel S. Pope, Murillo F. Rodrigues, Silas Tittes, Linh N. Tran, Ornob Alam, Maria Izabel Alves Cavassim, Peter D. Fields, Benjamin C. Haller, Xin Huang, Ben Jeffrey, Kevin Korfmann, Christopher C. Kyriazis, Jiseon Min, Ines Rebollo, Clara T Rehmann, Scott T. Small, Christopher C. R. Smith, Georgia […]


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Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

Posted by dbos UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Carlos Johnson-Cruz, Kathleen K.A. Cho and Vikaas S. Sohal | Summary: The mammalian prefrontal cortex encodes variables related to goal-directed behavior, and enables flexibility during environmental changes, making it critical to understand how the dynamic updating vs. stable maintenance of different encodings contribute to behavioral adaptation. We addressed this […]


Continue.. Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

Posted by dbos UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Carlos Johnson-Cruz, Kathleen K.A. Cho and Vikaas S. Sohal | Summary: The mammalian prefrontal cortex encodes variables related to goal-directed behavior, and enables flexibility during environmental changes, making it critical to understand how the dynamic updating vs. stable maintenance of different encodings contribute to behavioral adaptation. We addressed this […]


Continue.. Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

Causal Dynamics of Social Gaze in Primate Prefrontal-Amygdala Networks Revealed by Dynamic Bayesian Modeling

Posted by dbos Yale

Kavli Affiliate: Anirvan Nandy | Authors: Feng Xing, Siqi Fan, Olga Dal Monte, Monika Jadi, Steve Chang and Anirvan Nandy | Summary: Social gaze is a fundamental channel of primate communication, shaping dynamic interactions and fostering mutual understanding. While prior studies have mapped the behavioral correlates of social gaze across the prefrontal-amygdala circuits, the causal […]


Continue.. Causal Dynamics of Social Gaze in Primate Prefrontal-Amygdala Networks Revealed by Dynamic Bayesian Modeling