August 19, 2025 – Kavli Institute Pre-Print Publications

An Anterior Cingulate Cortex Neuronal Ensemble Controls Contextual Opioid Analgesic Tolerance

Posted by dbos August 19, 2025September 2, 2025Yale

Kavli Affiliate: Marina Picciotto | Rafael E Perez, Yann S Mineur, Cheryl Chen, Wenliang Zhou, Julian Lee Thompsom, Saagar S Motupally, Angelica Minier-Toribio and Marina R Picciotto | Summary: Despite well-established cellular and molecular adaptations, opioid analgesic tolerance can be rapidly reversed in settings where these drugs are not expected. The specific neuronal populations that […]

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Neuromodulator control of energy reserves in dopaminergic neurons

Posted by dbos August 19, 2025September 2, 2025Rockefeller

Kavli Affiliate: Timothy A. Ryan | Camila Pulido, Matthew S. Gentry and Timothy A. Ryan | Summary: The brain is a metabolically vulnerable organ as neurons have both high resting metabolic rates and the need for local rapid conversion of carbon sources to ATP during activity. Midbrain dopamine neurons are thought to be particularly vulnerable […]

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Dynamic representation of sound locations during task engagement in marmoset auditory cortex

Posted by dbos August 19, 2025September 2, 2025Hopkins

Kavli Affiliate: Patricia Janak | Shivam Kalhan, Robin Magnard, Yifeng Cheng and Patricia H. Janak | Summary: In auditory cortex, neural responses to stimuli inside receptive fields (RFs) can be further facilitated by behavioral demands, such as attending to a spatial location. It is less clear how off-RF stimuli modulate neural responses and contribute to […]

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Uncertainty and reward histories have distinct effects on decisions after wins and losses

Posted by dbos August 19, 2025September 2, 2025Hopkins

Kavli Affiliate: Patricia Janak | Shivam Kalhan, Robin Magnard, Yifeng Cheng and Patricia H. Janak | Summary: Intelligent behavior necessitates an adaptive integration of feedback. It is well-known that animals asymmetrically learn from positive and negative feedback. While asymmetrical learning is a robust behavioral effect, the latent computations behind how animals represent their environments and […]

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Neuroanatomical Basis of Coma in Acute Ischemic Stroke

Posted by dbos August 19, 2025September 2, 2025Rockefeller

Kavli Affiliate: Michael W. Young | Zheng Zhang, Milo White, Jennifer A Kim, Victor M Torres-Lopez, Aya Khalaf, David Jin, Aaron D Boes, Brian L Edlow, Stephen W English, David Fischer, Joel Geerling, Saleem M Halablab, Maarten G Lansberg, Margy McCullough-Hicks, James F Meschia, Patrik L Michel, Paola Palazzo, Benjamin D Reasoner, Robert W Regenhardt, […]

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Observation of stability of Gaussian beams and off-axis beam-cleaning in graded-index media

Posted by klaurent August 19, 2025September 2, 2025Cornell

Kavli Affiliate: Frank W. Wise | First 5 Authors: Varun Sharma, Varun Sharma, , , | Summary: While nonlinear effects in graded-index (GRIN) multimode fibers have been studied extensively, little is known about nonlinear effects in larger GRIN waveguides, where the number of modes approaches infinity and modal dispersion becomes negligible. Here we show that […]

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Nonadiabatic force matching for alchemical free-energy estimation

Posted by klaurent August 19, 2025Berkeley

Kavli Affiliate: David T. Limmer | First 5 Authors: Jorge L. Rosa-Raíces, Jorge L. Rosa-Raíces, , , | Summary: We propose a method to compute free-energy differences from nonadiabatic alchemical transformations using flow-based generative models. The method, nonadiabatic force matching, hinges on estimating the dissipation along an alchemical switching process in terms of a nonadiabatic […]

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Nonadiabatic force matching for alchemical free-energy estimation

Posted by klaurent August 19, 2025September 2, 2025Berkeley

Kavli Affiliate: David T. Limmer | First 5 Authors: Jorge L. Rosa-Raíces, Jorge L. Rosa-Raíces, , , | Summary: We propose a method to compute free energies from nonadiabatic alchemical transformations using diffusion-denoising generative models. The method, nonadiabatic force matching, hinges on estimating — rather than minimizing — the dissipation along an alchemical transition as […]

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Design, development, and commissioning of a flexible test setup for the AXIS prototype detector

Posted by klaurent August 19, 2025MIT

Kavli Affiliate: Marshall W. Bautz | First 5 Authors: Abigail Y. Pan, Abigail Y. Pan, , , | Summary: The Advanced X-ray Imaging Satellite (AXIS) is one of two candidate mission concepts selected for Phase-A study for the new NASA Astrophysics Probe Explorer (APEX) mission class, with a planned launch in 2032. The X-ray camera […]

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Design, development, and commissioning of a flexible test setup for the AXIS prototype detector

Posted by klaurent August 19, 2025Uncategorized

Kavli Affiliate: Gregory Prigozhin | First 5 Authors: Abigail Y. Pan, Abigail Y. Pan, , , | Summary: The Advanced X-ray Imaging Satellite (AXIS) is one of two candidate mission concepts selected for Phase-A study for the new NASA Astrophysics Probe Explorer (APEX) mission class, with a planned launch in 2032. The X-ray camera for […]

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