June 24, 2024 – Kavli Institute Pre-Print Publications

Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits

Posted by dbos June 24, 2024July 15, 2024UCSD / Salk

Kavli Affiliate: Nicola Allen | Authors: James Deng, Lara Labarta-Bajo, Ashley N Brandebura, Samuel B Kahn, Antonio F M Pinto, Jolene K Diedrich and Nicola J Allen | Summary: Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder with manifestations spanning molecular, neuroanatomical, and behavioral changes. Astrocytes contribute to FXS pathogenesis and show hundreds of […]

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Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination

Posted by dbos June 24, 2024July 15, 2024UCSF

Kavli Affiliate: Yifan Cheng | Authors: Xi Liu, Yang Li, Lennice Castro, Zanlin Yu, Yifan Cheng, Matthew D Daugherty and John D Gross | Summary: ZYG11B is a substrate specificity factor for Cullin-RING ubiquitin ligase (CRL2) involved in many biological processes, including Gly/N-degron pathways. Yet how the binding of ZYG11B with CRL2 is coupled to […]

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Nonlinear compliance of NompC gating spring and its implication in mechanotransduction

Posted by dbos June 24, 2024July 15, 2024UCSF

Kavli Affiliate: Yuh Nung and Jan Yifan Cheng and Yuh Nung Jan | Authors: Yukun Wang, Peng Jin, Avinash Kumar, Lily Jan, Yifan Cheng, Yuh-Nung Jan and Yongli Zhang | Summary: TCytoskeleton-tethered mechanosensitive channels (MSCs) utilize compliant proteins or protein domains called gating springs to convert mechanical stimuli into electric signals, enabling sound and touch […]

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Oxytocin receptor function regulates neural signatures of pair bonding and fidelity in the nucleus accumbens

Posted by dbos June 24, 2024July 15, 2024UCSF

Kavli Affiliate: Devanand Manoli | Authors: Kimberly Lorraine Page Long, Nerissa Emmy Graetz Hoglen, Alex J. Keip, Robert M. Klinkel, Déjenaé L. See, Joseph Maa, Jenna C. Wong, Michael Sherman and Devanand Manoli | Summary: The formation of enduring relationships dramatically influences future behavior, promoting affiliation between familiar individuals. How such attachments are encoded to […]

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AGN STORM 2: IX. Studying the Dynamics of the Ionized Obscurer in Mrk 817 with High-resolution X-ray Spectroscopy

Posted by dbos June 24, 2024MIT

Kavli Affiliate: Erin Kara | First 5 Authors: Fatima Zaidouni, Erin Kara, Peter Kosec, Missagh Mehdipour, Daniele Rogantini | Summary: We present the results of the XMM-Newton and NuSTAR observations taken as part of the ongoing, intensive multi-wavelength monitoring program of the Seyfert 1 galaxy Mrk 817 by the AGN Space Telescope and Optical Reverberation […]

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Nonparametric analysis of correlations in the binary black hole population with LIGO-Virgo-KAGRA data

Posted by dbos June 24, 2024MIT

Kavli Affiliate: Salvatore Vitale | First 5 Authors: Jack Heinzel, Matthew Mould, Salvatore Vitale, , | Summary: Formation channels of merging compact binaries imprint themselves on the distributions and correlations of their source parameters, but current understanding of this population is hindered by simplified parametric models. We overcome such limitations using PixelPop [Heinzel et al. […]

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Nonparametric analysis of correlations in the binary black hole population with LIGO-Virgo-KAGRA data

Posted by dbos June 24, 2024MIT

Kavli Affiliate: Salvatore Vitale | First 5 Authors: Jack Heinzel, Matthew Mould, Salvatore Vitale, , | Summary: Formation channels of merging compact binaries imprint themselves on the distributions and correlations of their source parameters. But current understanding of this population observed in gravitational waves is hindered by simplified parametric models. We overcome these limitations using […]

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PixelPop: High Resolution Nonparameteric Inference of Gravitational-Wave Populations in Multiple Dimensions

Posted by dbos June 24, 2024MIT

Kavli Affiliate: Salvatore Vitale | First 5 Authors: Jack Heinzel, Matthew Mould, Sofía Álvarez-López, Salvatore Vitale, | Summary: The origins of merging compact binaries observed by gravitational-wave detectors remains highly uncertain. Several astrophysical channels may contribute to the overall merger rate, with distinct formation processes imprinted on the structure and correlations in the underlying distributions […]

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PixelPop: High Resolution Nonparameteric Inference of Gravitational-Wave Populations in Multiple Dimensions

Posted by dbos June 24, 2024MIT

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Probing universal critical scaling with scan-DMRG

Posted by dbos June 24, 2024Delft

Kavli Affiliate: Natalia Chepiga | First 5 Authors: Natalia Chepiga, , , , | Summary: We explore the universal signatures of quantum phase transitions that can be extracted with the density matrix renormalization group (DMRG) algorithm applied to quantum chains with a gradient. We present high-quality data collapses for the order parameter and for the […]

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