Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits

Posted by dbos UCSD / Salk

Kavli Affiliate: Nicola Allen | Authors: James Deng, Lara Labarta-Bajo, Ashley N Brandebura, Samuel B Kahn, Antonio F M Pinto, Jolene K Diedrich and Nicola J Allen | Summary: Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder with manifestations spanning molecular, neuroanatomical, and behavioral changes. Astrocytes contribute to FXS pathogenesis and show hundreds of […]


Continue.. Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits

Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Xi Liu, Yang Li, Lennice Castro, Zanlin Yu, Yifan Cheng, Matthew D Daugherty and John D Gross | Summary: ZYG11B is a substrate specificity factor for Cullin-RING ubiquitin ligase (CRL2) involved in many biological processes, including Gly/N-degron pathways. Yet how the binding of ZYG11B with CRL2 is coupled to […]


Continue.. Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination

Nonlinear compliance of NompC gating spring and its implication in mechanotransduction

Posted by dbos UCSF

Kavli Affiliate: Yuh Nung and Jan Yifan Cheng and Yuh Nung Jan | Authors: Yukun Wang, Peng Jin, Avinash Kumar, Lily Jan, Yifan Cheng, Yuh-Nung Jan and Yongli Zhang | Summary: TCytoskeleton-tethered mechanosensitive channels (MSCs) utilize compliant proteins or protein domains called gating springs to convert mechanical stimuli into electric signals, enabling sound and touch […]


Continue.. Nonlinear compliance of NompC gating spring and its implication in mechanotransduction

Oxytocin receptor function regulates neural signatures of pair bonding and fidelity in the nucleus accumbens

Posted by dbos UCSF

Kavli Affiliate: Devanand Manoli | Authors: Kimberly Lorraine Page Long, Nerissa Emmy Graetz Hoglen, Alex J. Keip, Robert M. Klinkel, Déjenaé L. See, Joseph Maa, Jenna C. Wong, Michael Sherman and Devanand Manoli | Summary: The formation of enduring relationships dramatically influences future behavior, promoting affiliation between familiar individuals. How such attachments are encoded to […]


Continue.. Oxytocin receptor function regulates neural signatures of pair bonding and fidelity in the nucleus accumbens

Nonparametric analysis of correlations in the binary black hole population with LIGO-Virgo-KAGRA data

Posted by klaurent MIT

Kavli Affiliate: Salvatore Vitale | Summary:Formation channels of merging compact binaries imprint themselves on the distributions and correlations of their source parameters, but current understanding of this population is hindered by simplified parametric models. We overcome such limitations using PixelPop [Heinzel et al. (2025)]-our Bayesian nonparametric multidimensional population model. We analyze data from the first […]


Continue.. Nonparametric analysis of correlations in the binary black hole population with LIGO-Virgo-KAGRA data

PixelPop: High Resolution Nonparameteric Inference of Gravitational-Wave Populations in Multiple Dimensions

Posted by klaurent MIT

Kavli Affiliate: Salvatore Vitale | Summary:The origins of merging compact binaries observed by gravitational-wave detectors remains highly uncertain. Several astrophysical channels may contribute to the overall merger rate, with distinct formation processes imprinted on the structure and correlations in the underlying distributions of binary source parameters. In the absence of confident theoretical models, the current […]


Continue.. PixelPop: High Resolution Nonparameteric Inference of Gravitational-Wave Populations in Multiple Dimensions

MEReQ: Max-Ent Residual-Q Inverse RL for Sample-Efficient Alignment from Intervention

Posted by klaurent Berkeley

Kavli Affiliate: Xiang Zhang | First 5 Authors: Yuxin Chen, Yuxin Chen, , , | Summary: Aligning robot behavior with human preferences is crucial for deploying embodied AI agents in human-centered environments. A promising solution is interactive imitation learning from human intervention, where a human expert observes the policy’s execution and provides interventions as feedback. […]


Continue.. MEReQ: Max-Ent Residual-Q Inverse RL for Sample-Efficient Alignment from Intervention

Probing critical spin fluctuations with a composite magnetoelectric method: A case study on a Kitaev spin liquid candidate Na$_3$Co$_2$SbO$_6$

Posted by dbos UCAS

Kavli Affiliate: Long Zhang | First 5 Authors: Xinrun Mi, Xintong Li, Long Zhang, Aifeng Wang, Yuan Li | Summary: In correlated quantum materials, divergent critical fluctuations near the quantum critical point are often closely associated with exotic quantum phases of matter, such as unconventional superconductivity and quantum spin liquids. Here we present a simple […]


Continue.. Probing critical spin fluctuations with a composite magnetoelectric method: A case study on a Kitaev spin liquid candidate Na$_3$Co$_2$SbO$_6$