Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy

Kavli Affiliate: Jeffrey M. Friedman | Authors: Santiago R Unda, Roberta Marongiu, Lisa E Pomeranz, Jonathan P Dyke, Edward K Fung, Logan Grosenick, Rick Zirkel, Aldana M Antoniazzi, Sofya Norman, Conor M Liston, Chris B Schaffer, Nozomi Nishimura, Sarah A Stanley, Jeffrey M Friedman and Michael G Kaplitt | Summary: Regulating the activity of discrete […]


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Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance Enzyme

Kavli Affiliate: Michael Beer | Authors: Michael Beer, Ana Sofia F. Oliveira, Catherine L. Tooke, Philip Hinchliffe, Angie Tsz Yan Li, Balazs Balega, James Spencer and Adrian J Mulholland | Summary: β-Lactamases, which hydrolyse β-lactam antibiotics, are key determinants of antibiotic resistance. Predicting the sites and effects of distal mutations in enzymes is challenging. For […]


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Comparative Single Cell Analysis of Transcriptional Bursting Reveals the Role of Genome Organization on de novo Transcript Origination

Kavli Affiliate: Li Zhao | Authors: UnJin Lee, Cong Li, Christopher B Langer, Nicolas Svetec and Li Zhao | Summary: Spermatogenesis is a key developmental process underlying the origination of newly evolved genes. However, rapid cell type-specific transcriptomic divergence of the Drosophila germline has posed a significant technical barrier for comparative single-cell RNA-sequencing (scRNA-Seq) studies. […]


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Planet Hunters TESS V: a planetary system around a binary star, including a mini-Neptune in the habitable zone

Kavli Affiliate: Avi Shporer | First 5 Authors: Nora L. Eisner, Samuel K. Grunblatt, Oscar Barragán, Thea H. Faridani, Chris Lintott | Summary: We report on the discovery and validation of a transiting long-period mini-Neptune orbiting a bright (V = 9.0 mag) G dwarf (TOI 4633; R = 1.05 RSun, M = 1.10 MSun). The […]


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Colloidal dispersions of sterically and electrostatically stabilized PbS quantum dots: the effect of stabilization mechanism on structure factors, second virial coefficients, and film-forming properties

Kavli Affiliate: Naomi S. Ginsberg | First 5 Authors: Ahhyun Jeong, Josh Portner, Christian P. N. Tanner, Justin C. Ondry, Chenkun Zhou | Summary: Electrostatically stabilized nanocrystals (NCs) and, in particular, quantum dots (QDs) hold promise for forming strongly coupled superlattices due to their compact and electronically conductive surface ligands. However, studies on the colloidal […]


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An Agile Formal Specification Language Design Based on K Framework

Kavli Affiliate: Long Zhang | First 5 Authors: Jianyu Zhang, Long Zhang, Yixuan Wu, Feng Yang, | Summary: Formal Methods (FMs) are currently essential for verifying the safety and reliability of software systems. However, the specification writing in formal methods tends to be complex and challenging to learn, requiring familiarity with various intricate formal specification […]


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