Using a function-first “scout fragment”-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller, Ekaterina V. Vinogradova | Authors: Jared R Ramsey, Patrick M M Shelton, Tyler K. Heiss, Paul Dominic B Olinares, Lauren E Vostal, Heather Soileau, Michael Grasso, Sara Warrington, Stephanie Adaniya, Michael Miller, Shan Sun, David J Huggins, Robert W Myers, Brian T Chait, Ekaterina V Vinogradova and Tarun M Kapoor | […]


Continue.. Using a function-first “scout fragment”-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes

Small-scale signatures of primordial non-Gaussianity in k-Nearest Neighbour cumulative distribution functions

Posted by klaurent Stanford

Kavli Affiliate: Tom Abel | First 5 Authors: William R. Coulton, Tom Abel, Arka Banerjee, , | Summary: Searches for primordial non-Gaussianity in cosmological perturbations are a key means of revealing novel primordial physics. However, robustly extracting signatures of primordial non-Gaussianity from non-linear scales of the late-time Universe is an open problem. In this paper, […]


Continue.. Small-scale signatures of primordial non-Gaussianity in k-Nearest Neighbour cumulative distribution functions

Perfect Coulomb drag in a dipolar excitonic insulator

Posted by klaurent Cornell

Kavli Affiliate: Jie Shan | First 5 Authors: Phuong X. Nguyen, Liguo Ma, Raghav Chaturvedi, Kenji Watanabe, Takashi Taniguchi | Summary: Excitonic insulators (EIs), arising in semiconductors when the electron-hole binding energy exceeds the band gap, are a solid-state prototype for bosonic phases of matter. Unlike the charged excitations that are frozen and unable to […]


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TOI-199 b: A well-characterized 100-day transiting warm giant planet with TTVs seen from Antarctica

Posted by dbos MIT

Kavli Affiliate: Robert F. Goeke | First 5 Authors: Melissa J. Hobson, Trifon Trifonov, Thomas Henning, Andrés Jordán, Felipe Rojas | Summary: We present the spectroscopic confirmation and precise mass measurement of the warm giant planet TOI-199 b. This planet was first identified in TESS photometry and confirmed using ground-based photometry from ASTEP in Antarctica […]


Continue.. TOI-199 b: A well-characterized 100-day transiting warm giant planet with TTVs seen from Antarctica

TOI-199 b: A well-characterized 100-day transiting warm giant planet with TTVs seen from Antarctica

Posted by dbos MIT

Kavli Affiliate: Robert F. Goeke | First 5 Authors: Melissa J. Hobson, Trifon Trifonov, Thomas Henning, Andrés Jordán, Felipe Rojas | Summary: We present the spectroscopic confirmation and precise mass measurement of the warm giant planet TOI-199 b. This planet was first identified in TESS photometry and confirmed using ground-based photometry from ASTEP in Antarctica […]


Continue.. TOI-199 b: A well-characterized 100-day transiting warm giant planet with TTVs seen from Antarctica

Manifestly covariant variational principle for gauge theories of gravity

Posted by klaurent Cambridge

Kavli Affiliate: Anthony Lasenby | First 5 Authors: Michael Hobson, Anthony Lasenby, Will Barker, , | Summary: A variational principle for gauge theories of gravity is presented, which maintains manifest covariance under the symmetries to which the action is invariant, throughout the calculation of the equations of motion and conservation laws. This is performed by […]


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Clump-scale Gas Infall in High-mass Star Formation: a Multi-transition View with JCMT HCN (4–3) Mapping

Posted by klaurent Peking

Kavli Affiliate: Ke Wang | First 5 Authors: Fengwei Xu, Ke Wang, Yuxin He, Jingwen Wu, Lei Zhu | Summary: Gas infall motions play a crucial role in high-mass star formation and are characterized by observable signatures in the form of blue-shifted asymmetric spectral line profiles ("blue profiles"). However, the connection between blue profiles and […]


Continue.. Clump-scale Gas Infall in High-mass Star Formation: a Multi-transition View with JCMT HCN (4–3) Mapping

Multiferroic Magnon Spin-Torque Based Reconfigurable Logic-In-Memory

Posted by klaurent Cornell

Kavli Affiliate: Daniel C. Ralph | First 5 Authors: Yahong Chai, Yuhan Liang, Cancheng Xiao, Yue Wang, Bo Li | Summary: Magnons, bosonic quasiparticles carrying angular momentum, can flow through insulators for information transmission with minimal power dissipation. However, it remains challenging to develop a magnon-based logic due to the lack of efficient electrical manipulation […]


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Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy

Posted by klaurent UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Guillaume A Castillon, Sebastien Phan, Junru Hu, Daniela Boassa, Stephen R Adams and Mark H Ellisman | Summary: The binding and interaction of proteins with nucleic acids such as DNA and RNA constitutes a fundamental biochemical and biophysical process in all living organisms. Identifying and visualizing such temporal interactions […]


Continue.. Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy