Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Kavli Affiliate: Jean Fan | Authors: Rafael dos Santos Peixoto, Brendan F Miller, Maigan A Brusko, Lyla Atta, Manjari Anant, Mark A Atkinson, Todd M Brusko, Clive H Wasserfall and Jean Fan | Summary: Spatially resolved omics technologies provide molecular profiling of cells while preserving their organization within tissues, allowing for the evaluation of cell-type […]


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Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals

Kavli Affiliate: Michael Beer | Authors: Jin Woo Oh and Michael A Beer | Summary: Gene regulatory elements drive many complex biological phenomena such as fetal development, and their mutations are linked to a multitude of common human diseases. The phenotypic impacts of regulatory variants are often tested using their conserved orthologous counterparts in model […]


Continue.. Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals

Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Kavli Affiliate: Michael J Higley | Authors: Samantha Bottom-Tanzer, Sofia Corella, Jochen Meyer, Mary Sommer, Luis Bolanos, Timothy Murphy, Sadi Quinones, Shane Heiney, Matthew Shtrahman, Michael Whalen, Rachel Oren, Michael J Higley, Jessica A Cardin, Farzad Noubary, Moritz Armbruster and Chris Dulla | Summary: Traumatic brain injury (TBI) is the leading cause of death in […]


Continue.. Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Robust cosmological inference from non-linear scales with k-th nearest neighbor statistics

Kavli Affiliate: Tom Abel | First 5 Authors: Sihan Yuan, Tom Abel, Risa H. Wechsler, , | Summary: We present the methodology for deriving accurate and reliable cosmological constraints from non-linear scales (<50Mpc/h) with k-th nearest neighbor (kNN) statistics. We detail our methods for choosing robust minimum scale cuts and validating galaxy-halo connection models. Using […]


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Exploring chemical enrichment of the intracluster medium with the Line Emission Mapper

Kavli Affiliate: Mark Vogelsberger | First 5 Authors: François Mernier, Yuanyuan Su, Maxim Markevitch, Congyao Zhang, Aurora Simionescu | Summary: Synthesized in the cores of stars and supernovae, most metals disperse over cosmic scales and are ultimately deposited well outside the gravitational potential of their host galaxies. Since their presence is well visible through their […]


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Phospholipid transport to the bacterial outer membrane through an envelope-spanning bridge

Kavli Affiliate: Robert E. Clark | Authors: Georgia Isom, Benjamin F Cooper, Robert Clark, Anju Kudhail, Damian Charles Ekiert, Gira Bhabha and Syma Khalid | Summary: The outer membrane of Gram-negative bacteria provides a formidable barrier, essential for both pathogenesis and antimicrobial resistance. Biogenesis of the outer membrane requires the transport of phospholipids across the […]


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Structure-Function Coupling in Highly Sampled Individual Brains

Kavli Affiliate: Deanna J. Greene | Authors: Aishwarya Rajesh, Nicole A. Seider, Dillan J. Newbold, Babatunde Adeyemo, Scott Marek, Deanna J. Greene, Abraham Z Snyder, Joshua S. Shimony, Timothy O Laumann, Nico U.F. Dosenbach and Evan M. Gordon | Summary: Structural connections (SC) between distant regions of the brain support synchronized function known as functional […]


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Mice require proprioception to establish long-term visuospatial memory

Kavli Affiliate: Michael Goldberg | Authors: Michael E. Goldberg, Olivia Rutler, Randy M. Bruno, Jung Man Park, Serena Persaud, Stylianos Kosmidis and Nina Hirano | Summary: Because the retina moves constantly, the retinotopic representation of the visual world is spatially inaccurate and the brain must transform this spatially inaccurate retinal signal to a spatially accurate […]


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Phonon engineering of atomic-scale defects in superconducting quantum circuits

Kavli Affiliate: Oskar Painter | First 5 Authors: Mo Chen, John Clai Owens, Harald Putterman, Max Schäfer, Oskar Painter | Summary: Noise within solid-state systems at low temperatures, where many of the degrees of freedom of the host material are frozen out, can typically be traced back to material defects that support low-energy excitations. These […]


Continue.. Phonon engineering of atomic-scale defects in superconducting quantum circuits