Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

Posted by klaurent UCSF

Kavli Affiliate: Peter Walter | Authors: Rochelle Coulson, Valentina Frattini, Caitlin Moyer, Jennifer Hodges, Peter Walter, Philippe Mourrain, Yi Zuo and Gordon Wang | Summary: Fragile X syndrome (FXS) is caused by the functional loss of Fragile X messenger ribonucleoprotein (FMRP), a translational regulator that binds the transcripts of many proteins involved in synaptic function […]


Continue.. Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

Ambiguity, Invisibility, and Negativity

Posted by klaurent MIT

Kavli Affiliate: Frank Wilczek | First 5 Authors: Frank Wilczek, , , , | Summary: Many widely different problems have a common mathematical structure wherein limited knowledge lead to ambiguity that can be captured conveniently using a concept of invisibility that requires the introduction of negative values for quantities that are inherently positive. Here I […]


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The Effectiveness of Security Interventions on GitHub

Posted by klaurent Berkeley

Kavli Affiliate: Felix Fischer | First 5 Authors: Felix Fischer, Jonas Höbenreich, Jens Grossklags, , | Summary: In 2017, GitHub was the first online open source platform to show security alerts to its users. It has since introduced further security interventions to help developers improve the security of their open source software. In this study, […]


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The Effectiveness of Security Interventions on GitHub

Posted by klaurent Berkeley

Kavli Affiliate: Felix Fischer | First 5 Authors: Felix Fischer, Jonas Höbenreich, Jens Grossklags, , | Summary: In 2017, GitHub was the first online open source platform to show security alerts to its users. It has since introduced further security interventions to help developers improve the security of their open source software. In this study, […]


Continue.. The Effectiveness of Security Interventions on GitHub

The Effectiveness of Security Interventions on GitHub

Posted by klaurent Berkeley

Kavli Affiliate: Felix Fischer | First 5 Authors: Felix Fischer, Jonas Höbenreich, Jens Grossklags, , | Summary: Since 2017, GitHub has been the first online open source platform to show security warnings to its users. It has since introduced further security interventions to help developers improve the security of their open source software. In this […]


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Bridging two quantum quench problems — local joining quantum quench and Möbius quench — and their holographic dual descriptions

Posted by klaurent UCAS

Kavli Affiliate: Masahiro Nozaki | First 5 Authors: Jonah Kudler-Flam, Masahiro Nozaki, Tokiro Numasawa, Shinsei Ryu, Mao Tian Tan | Summary: We establish an equivalence between two different quantum quench problems, the joining local quantum quench and the M"obius quench, in the context of $(1+1)$-dimensional conformal field theory (CFT). Here, in the former, two initially […]


Continue.. Bridging two quantum quench problems — local joining quantum quench and Möbius quench — and their holographic dual descriptions

Endogenous Opioid Signaling Regulates Proliferation of Spinal Cord Ependymal Cells

Posted by klaurent UCSF

Kavli Affiliate: Xin Duan | Authors: Wendy W.S. Yue, Kouki K. Touhara, Kenichi Toma, Xin Duan and David Julius | Summary: After injury, mammalian spinal cords develop scars to seal off the damaged area and prevent further injury. However, excessive scarring can hinder neural regeneration and functional recovery (1, 2). These competing actions underscore the […]


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EIGER V. Characterizing the Host Galaxies of Luminous Quasars at $zgtrsim6$

Posted by dbos MIT

Kavli Affiliate: Robert A. Simcoe | First 5 Authors: Minghao Yue, Anna-Christina Eilers, Robert A. Simcoe, Ruari Mackenzie, Jorryt Matthee | Summary: We report {em JWST}/NIRCam measurements of quasar host galaxy emissions and supermassive black hole (SMBH) masses for six quasars at $5.9<z<7.1$ in the textit{Emission-line galaxies and Intergalactic Gas in the Epoch of Reionization} […]


Continue.. EIGER V. Characterizing the Host Galaxies of Luminous Quasars at $zgtrsim6$

EIGER V. Characterizing the Host Galaxies of Luminous Quasars at $zgtrsim6$

Posted by klaurent MIT

Kavli Affiliate: Robert A. Simcoe | First 5 Authors: Minghao Yue, Anna-Christina Eilers, Robert A. Simcoe, Ruari Mackenzie, Jorryt Matthee | Summary: We report {em JWST}/NIRCam measurements of quasar host galaxy emissions and supermassive black hole (SMBH) masses for six quasars at $5.9<z<7.1$ in the textit{Emission-line galaxies and Intergalactic Gas in the Epoch of Reionization} […]


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Multi-Octave Frequency Comb from an Ultra-Low-Threshold Nanophotonic Parametric Oscillator

Posted by klaurent Caltech

Kavli Affiliate: Alireza Marandi | First 5 Authors: Ryoto Sekine, Robert M. Gray, Luis Ledezma, Selina Zhou, Qiushi Guo | Summary: Ultrabroadband frequency combs coherently unite distant portions of the electromagnetic spectrum. They underpin discoveries in ultrafast science and serve as the building blocks of modern photonic technologies. Despite tremendous progress in integrated sources of […]


Continue.. Multi-Octave Frequency Comb from an Ultra-Low-Threshold Nanophotonic Parametric Oscillator