LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia Through MiT-TFE Transcription Factor Inhibition

Posted by klaurent Yale

Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Cells maintain optimal levels of lysosome degradative activity to protect against pathogens, clear waste and generate nutrients. Here we show that LRRK2, a protein that is tightly linked to Parkinson’s disease, negatively regulates lysosome degradative activity in macrophages and microglia via […]


Continue.. LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia Through MiT-TFE Transcription Factor Inhibition

Reports of the death of brain-behavior associations have been greatly exaggerated

Posted by klaurent UCSD / Salk

Kavli Affiliate: Timothy Brown, Anders Dale | Authors: Carolina Makowski, Timothy T Brown, Weiqi Zhao, Donald J Hagler, Pravesh Parekh, Hugh Garavan, Thomas E Nichols, Terry L Jernigan and Anders M Dale | Summary: Magnetic resonance imaging (MRI) has been a popular and useful non-invasive method to map patterns of brain structure and function to […]


Continue.. Reports of the death of brain-behavior associations have been greatly exaggerated

TOI-908: a planet at the edge of the Neptune desert transiting a G-type star

Posted by klaurent MIT

Kavli Affiliate: Alan M. Levine | First 5 Authors: Faith Hawthorn, Daniel Bayliss, David J. Armstrong, Jorge Fernández Fernández, Ares Osborn | Summary: We present the discovery of an exoplanet transiting TOI-908 (TIC-350153977) using data from TESS sectors 1, 12, 13, 27, 28 and 39. TOI-908 is a T = 10.7 mag G-dwarf ($T_{eff}$ = […]


Continue.. TOI-908: a planet at the edge of the Neptune desert transiting a G-type star

The Intrinsic Alignment of Galaxy Clusters and Impact of Projection Effects

Posted by dbos Tokyo

Kavli Affiliate: Masahiro Takada | First 5 Authors: Jingjing Shi, Tomomi Sunayama, Toshiki Kurita, Masahiro Takada, Sunao Sugiyama | Summary: Galaxy clusters, being the most massive objects in the Universe, exhibit the strongest alignment with the large-scale structure. However, mis-identification of members due to projection effects from the large scale structure can occur. We studied […]


Continue.. The Intrinsic Alignment of Galaxy Clusters and Impact of Projection Effects

The Intrinsic Alignment of Galaxy Clusters and Impact of Projection Effects

Posted by dbos Tokyo

Kavli Affiliate: Masahiro Takada | First 5 Authors: Jingjing Shi, Tomomi Sunayama, Toshiki Kurita, Masahiro Takada, Sunao Sugiyama | Summary: Galaxy clusters, being the most massive objects in the Universe, exhibit the strongest alignment with the large-scale structure. However, mis-identification of members due to projection effects from the large scale structure can occur. We studied […]


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Environmental dependence of Type IIn supernova properties

Posted by klaurent Peking

Kavli Affiliate: Subo Dong | First 5 Authors: Takashi J. Moriya, Lluis Galbany, Cristina Jimenez-Palau, Joseph P. Anderson, Hanindyo Kuncarayakti | Summary: Type IIn supernovae occur when stellar explosions are surrounded by dense hydrogen-rich circumstellar matter. The dense circumstellar matter is likely formed by extreme mass loss from their progenitors shortly before they explode. The […]


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The MAGPI Survey: Impact of environment on the total internal mass distribution of galaxies in the last 5 Gyr

Posted by klaurent Peking

Kavli Affiliate: Yingjie Peng | First 5 Authors: Caro Derkenne, Richard M. McDermid, Adriano Poci, J. Trevor Mendel, Francesco D’Eugenio | Summary: We investigate the impact of environment on the internal mass distribution of galaxies using the Middle Ages Galaxy Properties with Integral field spectroscopy (MAGPI) survey. We use 2D resolved stellar kinematics to construct […]


Continue.. The MAGPI Survey: Impact of environment on the total internal mass distribution of galaxies in the last 5 Gyr

Tensor BM-Decomposition for Compression and Analysis of Video Data

Posted by dbos MIT

Kavli Affiliate: Eric Miller | First 5 Authors: Fan Tian, Misha E. Kilmer, Eric Miller, Abani Patra, | Summary: Given tensors $boldsymbol{mathscr{A}}, boldsymbol{mathscr{B}}, boldsymbol{mathscr{C}}$ of size $m times 1 times n$, $m times p times 1$, and $1times p times n$, respectively, their Bhattacharya-Mesner (BM) product will result in a third-order tensor of dimension $m […]


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Tensor BM-Decomposition for Compression and Analysis of Spatio-Temporal Third-order Data

Posted by klaurent MIT

Kavli Affiliate: Eric Miller | First 5 Authors: Fan Tian, Misha E. Kilmer, Eric Miller, Abani Patra, | Summary: Given tensors $boldsymbol{mathscr{A}}, boldsymbol{mathscr{B}}, boldsymbol{mathscr{C}}$ of size $m times 1 times n$, $m times p times 1$, and $1times p times n$, respectively, their Bhattacharya-Mesner (BM) product will result in a third order tensor of dimension […]


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Cosmic birefringence tomography with polarized Sunyaev Zel’dovich effect

Posted by klaurent Tokyo

Kavli Affiliate: Toshiya Namikawa | First 5 Authors: Toshiya Namikawa, Ippei Obata, , , | Summary: We consider the polarized Sunyaev-Zel’dovich (pSZ) effect for a tomographic probe of cosmic birefringence, including all relevant terms of the pSZ effect in the cosmic microwave background (CMB) observables, some of which were ignored in the previous works. The […]


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