Engineered retrovirus-like Arc extracellular vesicles for the in vivo targeted delivery of mRNA into the brain

Posted by klaurent Columbia

Kavli Affiliate: Robert Hawkins | Authors: Wenchao Gu, Sijin Luozhong, Ketaki Londhe, Nadine Elkasri, Simian Cai, Robert Hawkins, Zhefan Yuan, Kai Su-Greene, Margaret Cruz, Yu-Wei Chang, Patrick McMullen, Chunyan Wu, Changwoo Seo, Akash Guru, Wenting Gao, Tara Sarmiento, Chris Schaffer, Nozomi Nishimura, Richard Cerione, Melissa Warden, Robert Langer and Shaoyi Jiang | Summary: Abstract Systemic […]


Continue.. Engineered retrovirus-like Arc extracellular vesicles for the in vivo targeted delivery of mRNA into the brain

Visualizing and manipulating chiral interface states in a moiré quantum anomalous Hall insulator

Posted by dbos Berkeley

Kavli Affiliate: Michael F. Crommie | First 5 Authors: Canxun Zhang, Tiancong Zhu, Salman Kahn, Tomohiro Soejima, Kenji Watanabe | Summary: Moir’e systems made from stacked two-dimensional materials host novel correlated and topological states that can be electrically controlled via applied gate voltages. We have used this technique to manipulate Chern domains in an interaction-driven […]


Continue.. Visualizing and manipulating chiral interface states in a moiré quantum anomalous Hall insulator

Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs)

Posted by klaurent Rockefeller

Kavli Affiliate: Thomas P. Sakmar | Authors: Ilana B. Kotliar, Emilie Ceraudo, Kevin Kemelmakher-Liben, Deena A. Oren, Emily Lorenzen, Tea Dodig-Crnković, Mizuho Horioka-Duplix, Thomas Huber, Jochen M. Schwenk and Thomas P. Sakmar | Summary: Abstract Cholestatic itch is a severe and debilitating symptom in liver diseases with limited treatment options. The class A G protein-coupled […]


Continue.. Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs)

A General Framework for Removing Point Spread Function Additive Systematics in Cosmological Weak Lensing Analysis

Posted by dbos Tokyo

Kavli Affiliate: Masahiro Takada | First 5 Authors: Tianqing Zhang, Xiangchong Li, Roohi Dalal, Rachel Mandelbaum, Michael A. Strauss | Summary: Cosmological weak lensing measurements rely on a precise measurement of the shear two-point correlation function (2PCF) along with a deep understanding of systematics that affect it. In this work, we demonstrate a general framework […]


Continue.. A General Framework for Removing Point Spread Function Additive Systematics in Cosmological Weak Lensing Analysis

THESAN-HR: How does reionization impact early galaxy evolution?

Posted by klaurent MIT

Kavli Affiliate: Mark Vogelsberger | First 5 Authors: Josh Borrow, Rahul Kannan, Enrico Garaldi, Aaron Smith, Mark Vogelsberger | Summary: Early galaxies were the radiation source for reionization, with the photoheating feedback from the reionization process expected to reduce the efficiency of star formation in low mass haloes. Hence, to fully understand reionization and galaxy […]


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Search for an invisible $Z^prime$ in a final state with two muons and missing energy at Belle II

Posted by klaurent Tokyo

Kavli Affiliate: T. Higuchi | First 5 Authors: Belle II Collaboration, I. Adachi, K. Adamczyk, L. Aggarwal, H. Ahmed | Summary: The $L_{mu}-L_{tau}$ extension of the standard model predicts the existence of a lepton-flavor-universality-violating $Z^{prime}$ boson that couples only to the heavier lepton families. We search for such a $Z^prime$ through its invisible decay in […]


Continue.. Search for an invisible $Z^prime$ in a final state with two muons and missing energy at Belle II

Non-Abelian effects in dissipative photonic topological lattices

Posted by Caltech

Kavli Affiliate: Alireza Marandi | First 5 Authors: Midya Parto, Christian Leefmans, James Williams, Franco Nori, Alireza Marandi | Summary: Topology is central to phenomena that arise in a variety of fields, ranging from quantum field theory to quantum information science to condensed matter physics. Recently, the study of topology has been extended to open […]


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The alarm pheromone and alarm response of the clonal raider ant

Posted by klaurent Rockefeller

Kavli Affiliate: Daniel Kronauer | Authors: Lindsey E. Lopes, Erik T. Frank, Zsolt Kárpáti, Thomas Schmitt and Daniel J.C. Kronauer | Summary: Abstract Ants communicate via an arsenal of different pheromones produced in a variety of exocrine glands. For example, ants release alarm pheromones in response to danger to alert their nestmates and to trigger […]


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Microdissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice

Posted by klaurent NTNU

Kavli Affiliate: Menno Witter, Asgeir Kobro-Flatmoen | Authors: Katrine Sjaastad Hanssen, Menno P. Witter, Axel Sandvig, Ioanna Sandvig and Asgeir Kobro-Flatmoen | Summary: Abstract Background Primary neuronal cultures enable cell-biological studies of Alzheimer’s disease (AD), albeit typically non-neuron-specific. The first cortical neurons affected in AD reside in layer II of the lateralmost part of the […]


Continue.. Microdissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice

Structural basis for CaVα2δ:gabapentin binding

Posted by klaurent UCSF

Kavli Affiliate: Daniel Minor | Authors: Daniel L Minor, Jr., Zhou Chen and Abhisek Mondal | Summary: Abstract Gabapentinoid drugs for pain and anxiety act on the CaVα2δ-1 and CaVα2δ-2 subunits of high-voltage activated calcium channels (CaV1s and CaV2s). Here, we present the cryo-EM structure of the gabapentin-bound brain and cardiac CaV1.2/CaVβ3/CaVα2δ-1 channel. The data […]


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