Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson’s disease patients with PINK1 and PARK2 mutations

Posted by klaurent UCSD / Salk

Kavli Affiliate: Fred Gage | Authors: Utkarsh Tripathi, Idan Rosh, Ran Ben Ezer, Ritu Nayak, Ashwani Choudhary, Jose Djamus, Andreea Manole, Henry Houlden, Fred H. Gage and Shani Stern | Summary: Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. Primary symptoms of PD arise with the loss of dopaminergic (DA) neurons in […]


Continue.. Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson’s disease patients with PINK1 and PARK2 mutations

Structured information extraction from complex scientific text with fine-tuned large language models

Posted by dbos Berkeley

Kavli Affiliate: Kristin Persson | First 5 Authors: Alexander Dunn, John Dagdelen, Nicholas Walker, Sanghoon Lee, Andrew S. Rosen | Summary: Intelligently extracting and linking complex scientific information from unstructured text is a challenging endeavor particularly for those inexperienced with natural language processing. Here, we present a simple sequence-to-sequence approach to joint named entity recognition […]


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Two types of locus coeruleus norepinephrine neurons drive reinforcement learning

Posted by klaurent Hopkins

Kavli Affiliate: Jeremiah Cohen | Authors: Zhixiao Su and Jeremiah Y. Cohen | Summary: Abstract The cerebral cortex generates flexible behavior by learning. Reinforcement learning is thought to be driven by error signals in midbrain dopamine neurons. However, they project more densely to basal ganglia than cortex, leaving open the possibility of another source of […]


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Assessing the C/O Ratio Formation Diagnostic: A Potential Trend with Companion Mass

Posted by klaurent Stanford

Kavli Affiliate: Bruce Macintosh | First 5 Authors: Kielan K. W. Hoch, Quinn M. Konopacky, Christopher A. Theissen, Jean-Baptiste Ruffio, Travis S. Barman | Summary: The carbon-to-oxygen (C/O) ratio in an exoplanet atmosphere has been suggested as a potential diagnostic of planet formation. Now that a number of exoplanets have measured C/O ratios, it is […]


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Visuomotor interactions in the mouse forebrain mediated by extrastriate cortico-cortical pathways

Posted by klaurent NTNU

Kavli Affiliate: Menno Witter, Jonathan Whitlock | Authors: Karoline Hovde, Ida V. Rautio, Andrea Marie Hegstad, Menno P. Witter and Jonathan R. Whitlock | Summary: Abstract The mammalian visual system can be broadly divided into two functional processing pathways: a dorsal stream supporting visually and spatially guided actions, and a ventral stream enabling object recognition. […]


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Adult born hippocampal granule cells promote pattern separation by bidirectionally modulating the remapping of place and cue cells

Posted by klaurent Columbia

Kavli Affiliate: Rene Hen | Authors: Sebnem N. Tuncdemir, Andres D. Grosmark, Hannah Chung, Victor M. Luna, Clay O. Lacefield, Attila Losonczy and Rene Hen | Summary: Abstract The hippocampal dentate gyrus (DG) exhibits a unique form of neural plasticity that results from continuous integration of adult born neurons, referred to as ‘adult neurogenesis’. Recent […]


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Directional detection of dark matter with anisotropic response functions

Posted by klaurent Stanford

Kavli Affiliate: Noah Kurinsky | First 5 Authors: Christian Boyd, Yonit Hochberg, Yonatan Kahn, Eric David Kramer, Noah Kurinsky | Summary: Direct detection for sub-GeV dark matter is developing rapidly, with many novel experimental ideas and theoretical methods emerging. In this work, we extend the dielectric formalism for dark matter scattering to incorporate anisotropic material […]


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Directional detection of dark matter with anisotropic response functions

Posted by klaurent Stanford

Kavli Affiliate: Noah Kurinsky | First 5 Authors: Christian Boyd, Yonit Hochberg, Yonatan Kahn, Eric David Kramer, Noah Kurinsky | Summary: Direct detection for sub-GeV dark matter is developing rapidly, with many novel experimental ideas and theoretical methods emerging. In this work, we extend the dielectric formalism for dark matter scattering to incorporate anisotropic material […]


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Dual electro-optic frequency comb photonic thermometry

Posted by klaurent Stanford

Kavli Affiliate: Zeeshan Ahmed | First 5 Authors: Adam J. Fleisher, Zeeshan Ahmed, Tobias Herman, Matthew R. Hartings, | Summary: We report a precision realization of photonic thermometry using dual-comb spectroscopy to interrogate a $pi$-phase-shifted fiber Bragg grating. We achieve read-out stability of 7.5 mK at 1 s and resolve temperature changes of similar magnitude–sufficient […]


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Nostradamus: Weathering Worth

Posted by klaurent Stanford

Kavli Affiliate: Zeeshan Ahmed | First 5 Authors: Alapan Chaudhuri, Zeeshan Ahmed, Ashwin Rao, Shivansh Subramanian, Shreyas Pradhan | Summary: Nostradamus, inspired by the French astrologer and reputed seer, is a detailed study exploring relations between environmental factors and changes in the stock market. In this paper, we analyze associative correlation and causation between environmental […]


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