LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Posted by klaurent Yale

Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Variants in leucine rich repeat kinase 2 (LRRK2) that increase kinase activity confer risk for sporadic and familial forms of Parkinson’s disease. However, LRRK2-dependent cellular processes responsible for disease risk remain uncertain. Here we show that LRRK2 negatively regulates lysosome degradative […]


Continue.. LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Posted by klaurent Yale

Kavli Affiliate: Nenad Sestan | Authors: Suel-Kee Kim, Seungmae Seo, Genevieve Stein-O’Brien, Amritha Jaishankar, Kazuya Ogawa, Nicola Micali, Victor Luria, Amir Karger, Yanhong Wang, Thomas M. Hyde, Joel E. Kleinman, Ty Voss, Elana J. Fertig, Joo-Heon Shin, Roland Bürli, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad […]


Continue.. Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Posted by klaurent UCSF

Kavli Affiliate: David Rowitch | Authors: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein and Amanda Brosius Lutz | Summary: The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing […]


Continue.. Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Multi-center integrated analysis of non-coding CRISPR screens

Posted by klaurent Hopkins

Kavli Affiliate: Michael Beer | Authors: David Yao, Josh Tycko, Woo Oh, Lexi R. Bounds, Sager J. Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R. Doughty, Idan Gabdank, Henri Schmidt, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunahi Luo, Keith Siklenka, Galip Gurkan Yardimci, The ENCODE4 Consortium, Ryan Tewhey, Anshul Kundaje, William J. Greenleaf, Pardis […]


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Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Posted by klaurent Cornell

Kavli Affiliate: Jeevak M. Parpia | First 5 Authors: Rakin N. Baten, Yefan Tian, Eric N. Smith, Erich Mueller, Jeevak M. Parpia | Summary: By monitoring the quality factor of a quartz tuning fork oscillator we have observed a fluctuation-driven reduction in the viscosity of bulk $^3$He in the normal state near the superfluid transition […]


Continue.. Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Posted by klaurent Cornell

Kavli Affiliate: Jeevak M. Parpia | First 5 Authors: Rakin N. Baten, Yefan Tian, Eric N. Smith, Erich Mueller, Jeevak M. Parpia | Summary: By monitoring the quality factor of a quartz tuning fork oscillator we have observed a fluctuation-driven reduction in the viscosity of bulk $^3$He in the normal state near the superfluid transition […]


Continue.. Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

First Flight Performance of the Micro-X Microcalorimeter X-Ray Sounding Rocket

Posted by dbos MIT

Kavli Affiliate: Sarah N. T. Heine | First 5 Authors: Joseph S. Adams, Robert Baker, Simon R. Bandler, Noemie Bastidon, Daniel Castro | Summary: The flight of the Micro-X sounding rocket on July 22, 2018 marked the first operation of Transition-Edge Sensors and their SQUID readouts in space. The instrument combines the microcalorimeter array with […]


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Recurrent flow patterns as a basis for turbulence: predicting statistics from structures

Posted by dbos Harvard

Kavli Affiliate: Michael P. Brenner | First 5 Authors: Jacob Page, Peter Norgaard, Michael P. Brenner, Rich R. Kerswell, | Summary: A dynamical systems approach to turbulence envisions the flow as a trajectory through a high-dimensional state space transiently visiting the neighbourhoods of unstable simple invariant solutions (E. Hopf, Commun. Appl. Maths 1, 303, 1948). […]


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Resonance fluorescence of a chiral artificial atom

Posted by dbos Caltech

Kavli Affiliate: Mohammad Mirhosseini | First 5 Authors: Chaitali Joshi, Frank Yang, Mohammad Mirhosseini, , | Summary: We demonstrate a superconducting artificial atom with strong unidirectional coupling to a microwave photonic waveguide. Our artificial atom is realized by coupling a transmon qubit to the waveguide at two spatially separated points with time-modulated interactions. Direction-sensitive interference […]


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Single-cell RNA sequencing analyses of primary cutaneous B-cell disorders reveal distinct molecular patterns consistent with clinical behavior

Posted by klaurent NTNU

Kavli Affiliate: Vy Thuy Nguyen | Authors: Johannes Griss, Mathias C Drach, Vy Nguyen, Jasmine P Levine, Felix Thaler, Marco A Medjimorec, Lisa E Shaw, Ulrike Mann, Wolfgang Weninger, Christine Wagner, Stephan Wagner, Ingrid Simonitsch-Klupp, Matthias Farlik, Constanze Jonak and Patrick M Brunner | Summary: Cutaneous B-cell lymphomas (CBL) comprise a diverse group of diseases […]


Continue.. Single-cell RNA sequencing analyses of primary cutaneous B-cell disorders reveal distinct molecular patterns consistent with clinical behavior