Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Jessica Mariani, Feinan Wu, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Jeremy Schreiner, Cindy Khanh Nguyen, Neal Nolan, Anna Szekely, James C. McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M. Vaccarino | Summary: Cell differentiation involves shifts in chromatin organization allowing transcription […]

Kavli Affiliate: Flora Vaccarino | Authors: Davide Capauto, Yifan Wang, Feinan Wu, Scott Norton, Jessica Mariani, Fumitaka Inoue, Gregory E. Crawford, The PsychENCODE Consortium, Nadav Ahituv, Alexej Abyzov and Flora M. Vaccarino | Summary: bstract Regulation of gene expression through enhancers is one of the major processes shaping the structure and function of the human […]

Kavli Affiliate: Pietro De Camilli | Authors: Chase Amos, Peng Xu and Pietro De Camilli | Summary: Mutations of the bridge-like lipid transport protein VPS13A and of the lipid scramblase XK result in Chorea Acanthocytosis (ChAc) and McLeod syndrome (MLS) respectively, two similar conditions involving neurodegeneration and deformed erythrocytes (acanthocytes). VPS13A binds XK, suggesting a […]

Kavli Affiliate: Damon Clark | Authors: Ryosuke Tanaka, Baohua Zhou, Margarida Agrochao, Bara A. Badwan, Braedyn Au, Natalia C. B. Matos and Damon A. Clark | Summary: In selecting appropriate behaviors, animals should weigh sensory evidence both for and against specific beliefs about the world. For instance, animals measure optic flow to estimate and control […]

Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Cells maintain optimal levels of lysosome degradative activity to protect against pathogens, clear waste and generate nutrients. Here we show that LRRK2, a protein that is tightly linked to Parkinson’s disease, negatively regulates lysosome degradative activity in macrophages and microglia via […]

Kavli Affiliate: Shawn Ferguson | Authors: JAEKWANG JEONG, Jongwon Lee, Gabriel Talaia, Wonnam Kim, Junho Song, Juhyeon Hong, Kwangmin Yoo, David Gonzalez, Diana Athonvarangkul, Jaehun Shin, Pamela Dann, Ann Haberman, Lark Kyun Kim, Shawn Ferguson, Jungmin Choi and John Wysolmerski | Summary: Read More

Kavli Affiliate: Damon Clark | Authors: Omer Mano, Minseung Choi, Ryosuke Tanaka, Matthew S. Creamer, Natalia C.B. Matos, Joseph Shomar, Bara A. Badwan, Thomas R. Clandinin and Damon A. Clark | Summary: Locomotor movements cause visual images to be displaced across the eye, a retinal slip that is counteracted by stabilizing reflexes in many animals. […]

Kavli Affiliate: Elena Gracheva | Authors: Yury A Nikolaev, Luke H Ziolkowski, Song Pang, Wei-Ping Li, Viktor V Feketa, C Shan Xu, Elena O Gracheva and Sviatoslav N Bagriantsev | Summary: Mechanosensory corpuscles detect transient touch and vibratory signals in the skin of vertebrates, enabling navigation, foraging, and precise manipulation of objects1. The corpuscle core […]

Kavli Affiliate: Elena Gracheva | Authors: Sarah M Mohr, Rafael Dai Pra, Maryann P Platt, Viktor V Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K Merriman, Tamas L Horvath, Sviatoslav N Bagriantsev and Elena O Gracheva | Summary: Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal […]