Yale – Page 3 – Kavli Institute Pre-Print Publications

Dopamine D1 receptor expression in dlPFC inhibitory parvalbumin neurons may contribute to higher visuospatial distractibility in marmosets versus macaques

Posted by dbos July 2, 2024July 15, 2024Yale

Kavli Affiliate: Anirvan Nandy | Authors: Mary Kate P Joyce, Tsvetoslav G Ivanov, Fenna Krienen, Jude Mitchell, Shaojie Ma, Wataru Inoue, Anirvan P Nandy, Dibyadeep Datta, Alvaro Duque, Jon I Arellano, Rahul Gupta, Guillermo Gonzalez-Burgos, David A Lewis, Nenad Sestan, Steven A McCarroll, Julio C Martinez-Trujillo, Seán Froudist-Walsh and Amy FT Arnsten | Summary: Marmosets […]

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Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline

Posted by dbos June 22, 2024July 9, 2024Yale

Kavli Affiliate: Flora Vaccarino | Authors: Yeongjun Jang, Livia Tomasini, Taejeong Bae, Anna Szekely, Flora M. Vaccarino and Alexej Abyzov | Summary: Little is known about the origin of germ cells in humans. We previously leveraged post-zygotic mutations to reconstruct zygote-rooted cell lineage ancestry trees in a phenotypically normal woman, termed NC0. Here, by sequencing […]

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Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson′s disease

Posted by dbos Yale

Kavli Affiliate: Michael J Higley | Authors: Saroj Sah, Andrew D Sauerbeck, Jyoti Gupta, Dayana Pérez-Acuña, Jacob E Reiber, Dreson Russell, Thomas Goralski, Michael Henderson, Laura A Volpicelli-Daley, Michael J Higley, Terrance T Kummer and Thomas Biederer | Summary: Cognitive impairment is a frequent non-motor symptom in Parkinson’s disease, and cortical Lewy pathology is strongly […]

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Dopamine D1 receptor expression in dlPFC inhibitory parvalbumin neurons may contribute to higher visuospatial distractibility in marmosets versus macaques

Posted by dbos June 16, 2024June 24, 2024Yale

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Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells

Posted by dbos June 14, 2024June 24, 2024Yale

Kavli Affiliate: Flora Vaccarino | Authors: Xoel Mato-Blanco, Suel-Kee Kim, Alexandre Jourdon, Shaojie Ma, Andrew T.N. Tebbenkamp, Fuchen Liu, Alvaro Duque, Flora M. Vaccarino, Nenad Sestan, Carlo Colantuoni, Pasko Rakic, Gabriel Santpere and Nicola Micali | Summary: The implications of the early phases of human telencephalic development, involving neural stem cells (NSCs), in the etiology […]

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Broken time reversal symmetry in visual motion detection

Posted by dbos June 10, 2024June 24, 2024Yale

Kavli Affiliate: Damon Clark | Authors: Nathan Wu, Baohua Zhou, Margarida Agrochao and Damon A Clark | Summary: Our intuition suggests that when a movie is played in reverse, our perception of motion in the reversed movie will be perfectly inverted compared to the original. This intuition is also reflected in many classical theoretical and […]

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Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

Posted by dbos June 8, 2024June 17, 2024Yale

Kavli Affiliate: Pietro De Camilli; | Authors: Xinbo Wang, Peng Xu, Amanda Bentley-DeSousa, William Hancock-Cerutti, Shujun Cai, Benjamin T Johnson, Francesca Tonelli, Gabriel Talaia, Dario R Alessi, Shawn M Ferguson and Pietro De Camilli | Summary: Based on genetic studies, lysosome dysfunction is thought to play a pathogenetic role in Parkinson’s disease (PD). Here we […]

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Role of microglia in stress-induced alcohol intake in female and male mice

Posted by dbos June 6, 2024June 17, 2024Yale

Kavli Affiliate: Marina Picciotto; | Authors: Alexa Soares, Vernon Garcia-Rivas, Caroline Fai, Merrilee Thomas, Xiaoying Zheng, Marina Picciotto and Yann Mineur | Summary: Rates of alcohol use disorder (AUD) have escalated in recent years, with a particular increase among women. Women are more susceptible to stress-induced alcohol drinking, and preclinical data suggest that stress can […]

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Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Posted by dbos May 31, 2024June 17, 2024Rockefeller, Yale

Kavli Affiliate: Timothy A. Ryan and Pietro De Camilli; | Authors: Lorena Benedetti, Ruolin Fan, Aubrey V. Weigel, Andrew S. Moore, Patrick R. Houlihan, Mark Kittisopikul, Grace Park, Alyson Petruncio, Philip M. Hubbard, Song Pang, C. Shan Xu, Harald F. Hess, Stephan Saalfeld, Vidhya Rangaraju, David E. Clapham, Pietro De Camilli, Timothy A. Ryan and […]

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Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids

Posted by dbos May 19, 2024May 28, 2024Yale

Kavli Affiliate: Flora Vaccarino | Authors: Soraya Scuderi, Tae-Yun Kang, Alexandre Jourdon, Liang Yang, Feinan Wu, Alex Nelson, George M. Anderson, Jessica Mariani, VIVEKANANDA SARANGI, Alexej Abyzov, Andre Levchenko and Flora M. Vaccarino | Summary: The repertory of neurons generated by progenitor cells depends on their location along antero-posterior and dorso-ventral axes of the neural […]

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