Kavli Affiliate: Damon Clark | Authors: Garrett Sager, Fabian Cole Pallasdies, Robert Gowers, Snusha Ravikumar, Elizabeth Wu, Daniel Colon-Ramos, Susanne Schreiber and Damon A Clark | Summary: Summary: Neuronal function depends critically on the cell biological organization of mitochondria, which regulate calcium signals and produce energy, among other roles. However, little is known about how […]
Kavli Affiliate: Damon Clark | Authors: Parisa A Vaziri, Samuel D McDougle and Damon A Clark | Summary: To discern speech or appreciate music, the human auditory system detects how pitch increases or decreases over time. However, the algorithms used to detect changes in pitch, or pitch motion, are incompletely understood. Here, using psychophysics, computational […]
Kavli Affiliate: Marina Picciotto | Authors: Manoela V Fogaca, Fernanda Daher and Marina Picciotto | Summary: Major depressive disorder (MDD) is associated with disruptions in glutamatergic and GABAergic activity in the medial prefrontal cortex (mPFC), leading to altered synaptic formation and function. Low doses of ketamine rapidly rescue these deficits, inducing fast and sustained antidepressant […]
Kavli Affiliate: Denis Wirtz | Authors: CKyu Sang Han, Inbal B Sander, Jacqueline Kumer, Eric Preston Resnick, Clare Booth, Yebin Im, Guoqing Cheng, Bartholomew Starich, Ashley L Kiemen, Jude M Phillip, Sashank Reddy, Corrine Joshu, Joel Sunshine, Jeremy Walston, Denis Wirtz and Pei-Hsun Wu | Summary: Aging is a major driver of diseases in humans. […]
Kavli Affiliate: Darcy Peterka | Authors: Chloe L West, Georgia Bastos, Annabel Duran, Samen Nadeem, David A Ricci, Anna M Rader, Joseph A Wargo, Darcy S Peterka, Neil Van Leeuwen and Jordan P Hamm | Summary: Serotonergic psychedelics (e.g., psilocybin) have shown potential for treating psychiatric disorders, with therapeutic effects lasting weeks after a single […]
Kavli Affiliate: Kathleen Cullen | Authors: Arnaud P. J. Giese, Wei-Hsiang Weng, Katie S Kindt, Vanessa H. H. Chang, Jonathan S Montgomery, Evan M. Ratzan, Alisha J. Beirl, Roberto Aponte Rivera, Jeffrey M. Lotthammer, Sanket Walujkar, Mark P. Foster, Omid A. Zobeiri, Jeffrey R. Holt, Saima Riazuddin, Kathleen E. Cullen, Marcos Sotomayor and Zubair M […]
Kavli Affiliate: Denis Wirtz | Authors: Bartholomew Starich, Fan Yang, Derin Tanrioven, Heng-Chung Kung, Joanne Baek, Praful R. Nair, Pratik Kamat, Nico Macaluso, Joon Eoh, Kyu Sang Han, Luo Gu, Jeremey Walston, Sean Sun, Pei-Hsun Wu, Denis Wirtz and Jude M. Phillip | Summary: Cellular senescence is a major driver of aging and disease. Here […]
Kavli Affiliate: Anirvan Nandy | Authors: Mary Kate P Joyce, Tsvetoslav G Ivanov, Fenna Krienen, Jude Mitchell, Shaojie Ma, Wataru Inoue, Anirvan P Nandy, Dibyadeep Datta, Alvaro Duque, Jon I Arellano, Rahul Gupta, Guillermo Gonzalez-Burgos, David A Lewis, Nenad Sestan, Steven A McCarroll, Julio C Martinez-Trujillo, Seán Froudist-Walsh and Amy FT Arnsten | Summary: Marmosets […]
Kavli Affiliate: Flora Vaccarino | Authors: Yeongjun Jang, Livia Tomasini, Taejeong Bae, Anna Szekely, Flora M. Vaccarino and Alexej Abyzov | Summary: Little is known about the origin of germ cells in humans. We previously leveraged post-zygotic mutations to reconstruct zygote-rooted cell lineage ancestry trees in a phenotypically normal woman, termed NC0. Here, by sequencing […]
Kavli Affiliate: Michael J Higley | Authors: Saroj Sah, Andrew D Sauerbeck, Jyoti Gupta, Dayana Pérez-Acuña, Jacob E Reiber, Dreson Russell, Thomas Goralski, Michael Henderson, Laura A Volpicelli-Daley, Michael J Higley, Terrance T Kummer and Thomas Biederer | Summary: Cognitive impairment is a frequent non-motor symptom in Parkinson’s disease, and cortical Lewy pathology is strongly […]