Dynamic convergence of autism disorder risk genes across neurodevelopment

Kavli Affiliate: Ellen J. Hoffman | Authors: Meilin Fernandez Garcia, Kayla Retallick-Townsley, Novin Balafkan, April Pruitt, Elizabeth Davidson, Yi Dai, Sarah E Fitzpatrick, Tzu-Chieh Huang, Alfred Kibowen, Jonathan Warrell, Ran Meng, Zhiyuan Chu, Annabel Sen, Sophie Cohen, Olivia Livoti, Suha Khan, Charlotte Becker, Andre Luiz Teles Silva, Jenny Liu, Grace Dossou, Jen Cheung, Sadaf Ghorbani, […]


Continue.. Dynamic convergence of autism disorder risk genes across neurodevelopment

ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis

Kavli Affiliate: Pietro De Camilli | Authors: Devin M Fuller, Yumei Wu, Florian Schueder, Burha Rasool, Shanta Nag, Justin L. Korfhage, Rolando Garcia-Milian, Katerina D Melnyk, Joerg Bewersdorf, Pietro De Camilli and Thomas Melia | Summary: Autophagosomes form from seed membranes that expand through bulk-lipid transport via the bridge-like lipid transporter ATG2. The origins of […]


Continue.. ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis

Fly navigational responses to odor motion and gradient cues are tuned to plume statistics

Kavli Affiliate: Damon Clark | Authors: Samuel Brudner, Baohua Zhou, Viraaj Jayaram, Gustavo Madeira Santana, Damon Clark and Thierry Emonet | Summary: Odor cues guide animals to food and mates. Different environmental conditions can create differently patterned odor plumes, making navigation more challenging. Prior work has shown that animals turn upwind when they detect odor […]


Continue.. Fly navigational responses to odor motion and gradient cues are tuned to plume statistics

ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis

Kavli Affiliate: Pietro De Camilli | Authors: Hui Wang, Matthew Kazaleh, Rachel A. Gioscia-Ryan, Jessica Millar, Gerard Temprano-Sagrera, Sherri Wood, Fran Van Den Burgh, Muriel G Blin, Kathleen M Wragg, Adrain Luna, Robert Bruce Hawkins, Scott A Soleimanpour, Maria Sabater-Lleal, Chang Shu, Daniel A Beard, Gorav Ailawadi, Jane C Deng, Daniel R Goldstein and Morgan […]


Continue.. ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis

Dopamine D1 receptor expression in prefrontal parvalbumin neurons influences distractibility across species

Kavli Affiliate: Anirvan Nandy | Authors: Mary Kate P Joyce, Tsvetoslav G Ivanov, Fenna Krienen, Jude Mitchell, Shaojie Ma, Wataru Inoue, Anirvan P Nandy, Dibyadeep Datta, Alvaro Duque, Jon I Arellano, Rahul Gupta, Guillermo Gonzalez-Burgos, David A Lewis, Nenad Sestan, Steven A McCarroll, Julio C Martinez-Trujillo, Seán Froudist-Walsh and Amy FT Arnsten | Summary: Marmosets […]


Continue.. Dopamine D1 receptor expression in prefrontal parvalbumin neurons influences distractibility across species

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

Kavli Affiliate: Pietro De Camilli and Shawn Ferguson | Authors: Xinbo Wang, Peng Xu, Amanda Bentley-DeSousa, William Hancock-Cerutti, Shujun Cai, Benjamin T Johnson, Francesca Tonelli, Lin Shao, Gabriel Talaia, Dario R Alessi, Shawn M Ferguson and Pietro De Camilli | Summary: Based on genetic studies, lysosome dysfunction is thought to play a pathogenetic role in […]


Continue.. Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM

Kavli Affiliate: Pietro De Camilli | Authors: Michael G Hanna, Hely O Rodriguez Cruz, Kenshiro Fujise, Yumei Wu, C Shan Xu, Song Pang, Li Zhuoning, Mara Monetti and Pietro De Camilli | Summary: Recent studies have identified a family of rod-shaped proteins thought to mediate lipid transfer at intracellular membrane contacts by a bridge-like mechanism. […]


Continue.. BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM

Multiple interactions mediate the localization of BLTP2 at ER-PM contacts to control plasma membrane dynamics

Kavli Affiliate: Pietro De Camilli | Authors: Anbang Dai, Peng Xu, Chase Amos, Kenshiro Fujise, Yumei Wu, Han Yang, Julia N. Eisen, Andrés Guillén-Samander and Pietro De Camilli | Summary: BLTP2/KIAA0100, a bridge-like lipid transfer protein, was reported to localize at contacts of the endoplasmic reticulum (ER) with either the plasma membrane (PM) or recycling […]


Continue.. Multiple interactions mediate the localization of BLTP2 at ER-PM contacts to control plasma membrane dynamics

Dynamic modulation of social gaze by sex and familiarity in marmoset dyads

Kavli Affiliate: Anirvan Nandy | Authors: Feng Xing, Alec Graham Sheffield, Monika P. Jadi, Steve W. C. Chang and Anirvan S. Nandy | Summary: Social communication relies on the ability to perceive and interpret the direction of others’ attention, and is commonly conveyed through head orientation and gaze direction in humans and nonhuman primates. However, […]


Continue.. Dynamic modulation of social gaze by sex and familiarity in marmoset dyads

Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson′s disease and Dementia with Lewy bodies

Kavli Affiliate: Sreeganga Chandra | Authors: D J Vidyadhara, David Backstrom, Risha Chakraborty, Jiapeng Ruan, Jae-Min Park, Pramod K. Mistry and Sreeganga S. Chandra | Summary: GBA mutations are major risk factors for Parkinson′s disease (PD) and Dementia with Lewy Bodies (DLB), two common α-synucleinopathies associated with cognitive impairment. Here, we investigated the role of […]


Continue.. Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson′s disease and Dementia with Lewy bodies