Kavli Affiliate: Anirvan Nandy | Authors: Feng Xing, Alec Graham Sheffield, Monika P. Jadi, Steve W. C. Chang and Anirvan S. Nandy | Summary: Social communication relies on the ability to perceive and interpret the direction of others’ attention, and is commonly conveyed through head orientation and gaze direction in humans and nonhuman primates. However, […]
Kavli Affiliate: Sreeganga Chandra | Authors: D J Vidyadhara, David Backstrom, Risha Chakraborty, Jiapeng Ruan, Jae-Min Park, Pramod K. Mistry and Sreeganga S. Chandra | Summary: GBA mutations are major risk factors for Parkinson′s disease (PD) and Dementia with Lewy Bodies (DLB), two common α-synucleinopathies associated with cognitive impairment. Here, we investigated the role of […]
Kavli Affiliate: Anirvan Nandy, John Reynolds | Authors: Mitchell P Morton, Sachira Denagamage, Isabel J Blume, John H Reynolds, Monika P Jadi and Anirvan S Nandy | Summary: Identical stimuli can be perceived or go unnoticed across successive presentations, producing divergent behavioral outcomes despite similarities in sensory input. We sought to understand how fluctuations in […]
Kavli Affiliate: Shawn Ferguson | Authors: Amanda Bentley-DeSousa and Shawn Ferguson | Summary: Mutations that increase LRRK2 kinase activity have been linked to Parkinson’s disease and Crohn’s disease. LRRK2 is also activated by lysosome damage evoked by chemical and pathogenic stimuli. However, the endogenous cellular mechanisms that control LRRK2 kinase activity are not well understood. […]
Kavli Affiliate: Ellen J. Hoffman | Authors: Maya Wilde, Anahita Ghanbari, Tessa Mancienne, Ailís Moran, Rebecca E. Poulsen, Lena Constantin, Conrad Lee, Leandro Aluisio Scholz, Joshua Arnold, Wei Qin, Timothy J. Karle, Steven Petrou, Itia A. Favre-Bulle, Ellen J. Hoffman and Ethan K. Scott | Summary: IAuditory processing is widely understood to occur differently in […]
Kavli Affiliate: Damon Clark | Authors: Garrett Sager, Fabian Cole Pallasdies, Robert Gowers, Snusha Ravikumar, Elizabeth Wu, Daniel Colon-Ramos, Susanne Schreiber and Damon A Clark | Summary: Summary: Neuronal function depends critically on the cell biological organization of mitochondria, which regulate calcium signals and produce energy, among other roles. However, little is known about how […]
Kavli Affiliate: Damon Clark | Authors: Parisa A Vaziri, Samuel D McDougle and Damon A Clark | Summary: To discern speech or appreciate music, the human auditory system detects how pitch increases or decreases over time. However, the algorithms used to detect changes in pitch, or pitch motion, are incompletely understood. Here, using psychophysics, computational […]
Kavli Affiliate: Marina Picciotto | Authors: Manoela V Fogaca, Fernanda Daher and Marina Picciotto | Summary: Major depressive disorder (MDD) is associated with disruptions in glutamatergic and GABAergic activity in the medial prefrontal cortex (mPFC), leading to altered synaptic formation and function. Low doses of ketamine rapidly rescue these deficits, inducing fast and sustained antidepressant […]
Kavli Affiliate: Denis Wirtz | Authors: CKyu Sang Han, Inbal B Sander, Jacqueline Kumer, Eric Preston Resnick, Clare Booth, Yebin Im, Guoqing Cheng, Bartholomew Starich, Ashley L Kiemen, Jude M Phillip, Sashank Reddy, Corrine Joshu, Joel Sunshine, Jeremy Walston, Denis Wirtz and Pei-Hsun Wu | Summary: Aging is a major driver of diseases in humans. […]
Kavli Affiliate: Darcy Peterka | Authors: Chloe L West, Georgia Bastos, Annabel Duran, Samen Nadeem, David A Ricci, Anna M Rader, Joseph A Wargo, Darcy S Peterka, Neil Van Leeuwen and Jordan P Hamm | Summary: Serotonergic psychedelics (e.g., psilocybin) have shown potential for treating psychiatric disorders, with therapeutic effects lasting weeks after a single […]