Kavli Affiliate: Arnold R. Kriegstein | Authors: Tanzila Mukhtar, Clara-Vita Siebert, Yuejun Wang, Mark-Phillip Pebworth, Matthew L. White, Tianzhi Wu, Tan Ieng Huang, Guolong Zuo, Jayden Ross, Jennifer Baltazar, Varun Upadhyay, Merut Shankar, Li Zhou, Isabel Lombardi-Coronel, Ishaan Mandala, Manal A. Adam, Shaohui Wang, Qiuli Bi, Marco F.M. Hoekman, Jingjing Li and Arnold Kriegstein | […]
Kavli Affiliate: Robert Edwards | Authors: Aaron J May, Muralikrishna Lella, Jared Lindenberger, Alex Berkman, Ujjwal Kumar, Moumita Dutta, Maggie Barr, Rob Parks, Xiaozhi Lu, Madison Berry, Amanda Newman, Xiao Huang, Kijun Song, Victor Ilevbare, Salam Sammour, Chan Soo Park, Radha Devkota Adhikari, Priyanka Devkota, Katarzyna Janowska, Yanshun Liu, Garrett Scapellato, Taylor N Spence, Katayoun […]
Kavli Affiliate: Vikaas Sohal and Mazen Kheirbek | Authors: Odilia D Lu, Katrina White, Kendall Raymond, Christine Liu, Alexandra S Klein, Nathaniel Green, Sam Vaillancourt, Austin Gallagher, Lena Shindy, Alyssa Li, Ruoxian Li, Mila Zou, Kira Wallquist, Austen B Casey, Lindsay P Cameron, Matthew B Pomrenze, Vikaas Sohal, Mazen A Kheirbek, Andrea M Gomez, Stephan […]
Kavli Affiliate: Kevin Bender | Authors: Hao Wu, Luqun Shen, Jonathan Indajang, Neil K Savalia, Timothy G Johnson, Jiayin Qu, Kevin J Bender and Alex C Kwan | Summary: SCN2A is a high-confidence risk gene for autism spectrum disorder. Loss-of-function mutations in Scn2a reduce dendritic excitability in neocortical pyramidal cells. However, the impact of Scn2a […]
Kavli Affiliate: Kevin Bender | Authors: Joshua D Garcia, Chenyu Wang, Ryan Alexander, Emmie Banks, Timothy Fenton, Jean-Marc DeKeyser, Tatiana V Abramova, Alfred L George, Roy Ben-Shalom, David H Hackos and Kevin J Bender | Summary: Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. These isoforms are differentially localized […]
Kavli Affiliate: Alex Pollen | Authors: Nathan K Schaefer, Bryan J Pavlovic and Alex Aaron Pollen | Summary: Pooled processing, in which cells from multiple sources are cultured or captured together, is an increasingly popular strategy for droplet-based single cell sequencing studies. This design allows efficient scaling of experiments, isolation of cell-intrinsic differences, and mitigation […]
Kavli Affiliate: Robert Edwards | Authors: Laura K Inglis, Michael J Roach, Susanna R Grigson and Robert A. Edwards | Summary: Prophages—viruses that integrate into bacterial genomes—are ubiquitous in the microbial realm. Prophages contribute significantly to horizontal gene transfer, including the potential spread of antimicrobial resistance (AMR) genes, because they can collect host genes. Understanding […]
Kavli Affiliate: Kevin Bender | Authors: Mitchell J. Vaughn, Kevin J. Bender and Julie S. Haas | Summary: Electrical synapses are present widely across the mammalian brain and are crucial components of active neural circuitry and connectomes. Identification of electrically coupled networks in living tissue has been limited by technical demands of multiplexed recordings, and […]
Kavli Affiliate: Alexandra Nelson and Anatol Kreitzer | Authors: Katerina L Rademacher, Zak Doric, Dominik Haddad, Aphroditi Mamaligas, Szu-Chi Liao, Rose Creed, Kohei Kano, Zac Chatterton, Yuhong Fu, Joseph H Garcia, Victoria Vance, Yoshitaka Sei, Anatol Kreitzer, Glenda Halliday, Alexandra Nelson, Elyssa Margolis and Ken L Nakamura | Summary: Parkinson’s disease (PD) is characterized by […]
Kavli Affiliate: Peter Walter | Authors: Kristof Torkenczy, Lucas C Reineke, Sean W Dooling, Benjamin W Henderson, Daniel Itzhak, Benjamin Yang, Dongze He, Richard M Myers, Peter Walter, Stefka Tyanova and Mauro Costa-Mattioli | Summary: Persistent activation of the integrated stress response (ISR) is a major driver of cognitive decline in both neurodevelopmental and neurodegenerative […]