Kavli Affiliate: Michael Keiser | Authors: Sina Ghandian, Liane Albarghouthi, Kiana Nava, Shivam R. Rai Sharma, Lise Minaud, Laurel Beckett, Naomi Saito, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Lee-Way Jin, Brittany N. Dugger and Michael J. Keiser | Summary: Accumulation of abnormal tau protein into neurofibrillary tangles (NFTs) is a pathologic hallmark of […]
Kavli Affiliate: Joshua Berke and Loren Frank | Authors: Alison E. Comrie, Emily J. Monroe, Ari E. Kahn, Eric L. Denovellis, Abhilasha Joshi, Jennifer A. Guidera, Timothy A. Krausz, Joshua D. Berke, Nathaniel D. Daw and Loren M. Frank | Summary: Summary: The cognitive ability to go beyond the present to consider alternative possibilities, including […]
Kavli Affiliate: Keri Martinowich | Authors: Amber M Smith, Yang Li, Arianna Velarde, Yifan Cheng and Alan D. Frankel | Summary: Summary: Crm1 is a highly conserved nuclear exportin that transports >1000 human proteins including ribonucleoprotein (RNP) complexes. The interface between Crm1 and RNP cargos is unknown. The HIV regulatory protein, Rev, was one of […]
Kavli Affiliate: Michael Keiser | Authors: Mikio Tada, Garrett Gaskins, Sina Ghandian, Nicholas Mew, Michael J. Keiser and Elizabeth S. Keiser | Summary: Melanocytic atypia, ranging from benign to malignant, often leads to diagnostic discordance, complicating its prediction by machine learning models. To overcome this, we paired H&E-stained histology images with contiguous or serial sections […]
Kavli Affiliate: Reza Abbasi Asl and Philip Starr | Authors: Kara N Presbrey, Thomas A Wozny, Kenneth H Louie, Simon Little, Philip A Starr, Reza Abbasi-Asl and Doris D Wang | Summary: Learning fine motor sequences is crucial to quality of life and can be altered in Parkinson’s Disease (PD). It may be partially driven […]
Kavli Affiliate: Edward Chang | Authors: Elisabetta Furlanis, Min Dai, Brenda Leyva Garcia, Josselyn Vergara, Ana Pereira, Kenneth Pelkey, Thien Tran, Bram L. Gorissen, Anna Vlacho, Ariel Hairston, Shuhan Huang, Deepanjali Dwivedi, Sarah Du, Sara Wills, Justin McMahon, Anthony T. Lee, Edward F. Chang, Taha Razzaq, Ahmed Qazi, Geoffrey Vargish, Xiaoqing Yuan, Adam Caccavano, Steven […]
Kavli Affiliate: Hana El-Samad | Authors: Zara Y. Weinberg, Sarah S. Soliman, Matthew S. Kim, Irene P. Chen, Melanie Ott and Hana El-Samad | Summary: Synthetic and chimeric receptors capable of recognizing and responding to user-defined antigens have enabled “smart” therapeutics based on engineered cells. These cell engineering tools depend on antigen sensors which are […]
Kavli Affiliate: Yifan Cheng | Authors: Hayden S Saunders, Un Seng Chio, Camille M Moore, Vijay Ramani, Yifan Cheng and Geeta Narlikar | Summary: Summary: The essential architectural protein HMGB1 increases accessibility of nucleosomal DNA and counteracts the effects of linker histone H1. However, HMGB1 is less abundant than H1 and binds nucleosomes more weakly […]
Kavli Affiliate: Adam Gazzaley | Authors: Lorenzo Pasquini, Alexander Simon, Courtney Gallen, Hannes Kettner, Leor Roseman, Adam Gazzaley, Robin Carhart-Harris and Christopher Timmermann | Summary: N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory […]
Kavli Affiliate: Noelle L’Etoile and Saul Kato | Authors: Raymond L Dunn, Caitriona Costello, Jackson M Borchardt, Daniel Yutaka Sprague, Grace C Chiu, Julia M Miller, Noelle L’Etoile and Saul Kato | Summary: We report the existence of a working memory system in the nematode C. elegans that is employed for deferred action in a […]