Multiscale Cloud-based Pipeline for Neuronal Electrophysiology Analysis and Visualization

Kavli Affiliate: Edward Chang | Authors: Jinghui Geng, Kateryna Voitiuk, David F. Parks, Ash Robbins, Alex Spaeth, Jessica L. Sevetson, Sebastian Hernandez, Hunter E. Schweiger, John P. Andrews, Spencer T. Seiler, Matthew A. T. Elliott, Edward F. Chang, Tomasz J. Nowakowski, Rob Currie, Mohammed A. Mostajo-Radji, David Haussler, Tal Sharf, Sofie R. Salama and Mircea […]


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Motor learning leverages coordinated low-frequency cortico-basal ganglia activity to optimize motor preparation in humans with Parkinson’s Disease

Kavli Affiliate: Jeremy Willsey | Authors: Elina Kostyanovskaya, Micaela C. Lasser, Belinda Wang, James Schmidt, Ethel Bader, Chad Buteo, Juan Arbelaez, Aria Rani Sindledecker, Kate E. McCluskey, Octavio Castillo, Sheng Wang, Jeanselle Dea, Kathryn A. Helde, J. Michael Graglia, Elise Brimble, David B. Kastner, Aliza T. Ehrlich, Matthew W. State, A. Jeremy Willsey and Helen […]


Continue.. Motor learning leverages coordinated low-frequency cortico-basal ganglia activity to optimize motor preparation in humans with Parkinson’s Disease

Convergence of autism proteins at the cilium

Kavli Affiliate: Jeremy Willsey | Authors: Elina Kostyanovskaya, Micaela C. Lasser, Belinda Wang, James Schmidt, Ethel Bader, Chad Buteo, Juan Arbelaez, Aria Rani Sindledecker, Kate E. McCluskey, Octavio Castillo, Sheng Wang, Jeanselle Dea, Kathryn A. Helde, J. Michael Graglia, Elise Brimble, David B. Kastner, Aliza T. Ehrlich, Matthew W. State, A. Jeremy Willsey and Helen […]


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Oxytocin receptor controls promiscuity and development in prairie voles

Kavli Affiliate: Devanand Manoli and Jeremy Willsey | Authors: Ruchira Sharma, Kristen M. Berendzen, Amanda Everitt, Belinda Wang, Gina Williams, Shuyu Wang, Kara Quine, Rose D. Larios, Kimberly L. P. Long, Nerissa Hoglen, Bibi Alika Sulaman, Marie C. Heath, Michael Sherman, Robert Klinkel, Angela Cai, Denis Galo, Lizandro Chan Caamal, Nastacia L. Goodwin, Annaliese Beery, […]


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Mapping cis- and trans-regulatory target genes of human-specific deletions

Kavli Affiliate: Alex Pollen | Authors: Tyler Fair, Bryan J Pavlovic, Dani Swope, Octavio E Castillo, Nathan K Schaefer and Alex Aaron Pollen | Summary: Deletion of functional sequence is predicted to represent a fundamental mechanism of molecular evolution. Comparative genetic studies of primates have identified thousands of human-specific deletions (hDels), and the cis-regulatory potential […]


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Genome Organization with CUT and Tag (GO-CaT) identifies substructure and maturation of lamina-associated domains in neurons of the developing human brain

Kavli Affiliate: Arnold R. Kriegstein | Authors: Chujing Zhang, Eugene Gil, Sajad Hamid Ahanger, Mingcong Li, Li Wang, Jingjing Li, Arnold Kriegstein and Daniel Lim | Summary: Approximately 30-40% of the human genome is anchored to the nuclear lamina through variably sized (10 kb–10 Mb) lamina-associated domains (LADs). Previous work in cultured murine and human […]


Continue.. Genome Organization with CUT and Tag (GO-CaT) identifies substructure and maturation of lamina-associated domains in neurons of the developing human brain

Sphae: An automated toolkit for predicting phage therapy candidates from sequencing data

Kavli Affiliate: Robert Edwards | Authors: Bhavya Papudeshi, Michael J. Roach, Vijini Mallawaarachchi, George Bouras, Susanna R Grigson, Sarah K Giles, Clarice M Harker, Abbey L.K Hutton, Anita Tarasenko, Laura K Inglis, Alejandro A Vega, Cole Souza, Lance Boling, Hamza Hajama, Ana Georgina Cobian-Guemes, Anca Segall, Elizabeth A Dinsdale and Robert A Edwards | Summary: […]


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Long-term effects of psilocybin on dynamic and effectivity connectivity of fronto-striatal-thalamic circuits

Kavli Affiliate: Adam Gazzaley | Authors: Lorenzo Pasquini, Jakub Vohryzek, Anira Escrichs, Yonatan Sanz Perl, Adrian Ponce-Alvarez, Sebastian Idesis, Manesh Girn, Leor Roseman, Jennifer M Mitchell, Adam Gazzaley, Morten Kringelbach, David J Nutt, Taylor Lyons, Robin L Carhart-Harris and Gustavo Deco | Summary: Psilocybin has been shown to induce fast and sustained improvements in mental […]


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Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability

Kavli Affiliate: Alex Pollen | Authors: Sara Nolbrant, Jenelle L. Wallace, Jingwen Ding, Tianjia Zhu, Jess L. Sevetson, Janko Kajtez, Isabella A. Baldacci, Emily K. Corrigan, Kaylynn Hoglin, Reed McMullen, Matthew T. Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J. Pavlovic, Sofie R. Salama, Agnete Kirkeby, Hao Huang, Nathan K. Schaefer and Alex A. […]


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Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s Disease

Kavli Affiliate: Alexandra Nelson | Authors: Xiaowen Zhuang, Julia Lemak, Sadhana Sridhar and Alexandra B Nelson | Summary: Summary: Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive deficits, this coordination […]


Continue.. Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s Disease