Kavli Affiliate: Su Guo | Authors: Krishnashish Bose, Su Guo and Karnika Bhardwaj | Summary: Paradoxical kinesia—the temporary alleviation of motor deficits by powerful, urgent stimuli in Parkinson’s disease (PD)—remains poorly understood at the neural circuit level. Through chemo-genetic ablation of tyrosine hydroxylase-expressing neurons in larval zebrafish and brain-wide calcium imaging under head-fixed, tail-free conditions, […]

Kavli Affiliate: Jeanne Paz | Authors: Jeremy B Ford, Olive N Tambou, Jarret AP Weinrich, Debleena Chatterjee, Allan Basbaum and Jeanne T. Paz | Summary: Central post-stroke pain (CPSP) is a highly distressing condition that develops in 50% of people who suffer a thalamic stroke, and is typically unresponsive to current clinical treatments. Hypoxic damage […]

Kavli Affiliate: Vikaas Sohal | Authors: Xiyu Zhu, Lara L. Hagopian, Kira E. Wallquist and Vikaas Singh Sohal | Summary: While glutamatergic synaptic plasticity is believed to be a fundamental mechanism mediating learning, the behavioral significance of plasticity at cortical GABAergic synapses remains less well understood. Furthermore, despite recent discoveries of long-range projections from neocortical […]

Kavli Affiliate: Lily Jan and Yuh Nung Jan | Authors: Chin Fen Teo, Sami T Tuomivaara, Niek van Hilten, David Crottès, Yuh Nung Jan, Michael Grabe and Lily Y Jan | Summary: The asymmetric resting distribution of the three major phospholipid classes on the mammalian plasma membrane, with phosphatidylserine and phosphatidylethanolamine mostly on the inner […]

Kavli Affiliate: Arnold R. Kriegstein | Authors: Tianzhi Wu, lihua jiang, Tanzila Mukhtar, Li Wang, ruiqi jian, Cheng Wang, Tiffany Trinh, Arnold Kriegstein, Michael Snyder and Jingjing Li | Summary: Proteins are the functional effectors of virtually all biological processes, and accurately measuring their abundance and dynamics is essential for understanding development and disease. Although […]

Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Bart A Eijkelkamp, Timothy R Cavagnaro, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Garth Harmsworth, Damien J Keating, Robert A Edwards and Martin F Breed | Summary: The global rise in human allergic and autoimmune diseases is linked to altered environmental microbiome exposures from increasing […]

Kavli Affiliate: Michael Keiser | Authors: Benjamin Orr, Stephanie E Crilly, Deniz Akpinaroglu, Eleanor Zhu, Michael J. Keiser and Tanja Kortemme | Summary: Nature uses structural variations on protein folds to fine-tune the geometries of proteins for diverse functions, yet deep learning-based de novo protein design methods generate highly regular, idealized protein fold geometries that […]

Kavli Affiliate: Arnold R. Kriegstein | Authors: Chujing Zhang, Eugene Gil, Sajad Hamid Ahanger, Mingcong Li, Li Wang, Eric J. Huang, Jingjing Li, Arnold R. Kriegstein and Daniel A. Lim | Summary: Approximately 30-40% of the human genome is anchored to the nuclear lamina (NL) through variably sized (10 kb-10 Mb) lamina-associated domains (LADs), which […]

Kavli Affiliate: Vikaas Sohal | Authors: Cesar P Canales, Stephanie Lozano, Nicholas A Frost, Karol Cichewicz, Wellington Amaral, Nicolas Seban, Ethan Fenton, Ayanna Wade, Nickolas Chu, Emily Smith, Cory Ardekani, Samuel Frank, Jeffrey Bennett, Pierre Lavenex, Aspen Kopley-Smith, Darlene Rahbarian, Melisa Corea, Daniela Perla, Liam Davis, Jiyuan Zhu, Rebecca Ortiz, Paris Beauregard, Caitlin Moyer, Jacob […]

Kavli Affiliate: Robert Edwards | Authors: Rumi Habib, Ryan S. Roark, Hui Li, Andrew Jesse Connell, Michael P. Hogarty, Kshitij Wagh, Shuyi Wang, Lorie Marchitto, Ashwin N. Skelly, John W. Carey, Kirsten J. Sowers, Kasirajan Ayyanathan, Samantha J. Plante, Frederic Bibollet-Ruche, Younghoon Park, Colby J. Agostino, Ajay Singh, Christian L. Martella, Emily Lewis, Jinery Lora, […]