Prioritizing virtual screening with interpretable interaction fingerprints

Kavli Affiliate: Michael Keiser | Authors: Alexandre V Fassio, Laura Shub, Luca Ponzoni, Jessica McKinley, Matthew J O’Meara, Rafaela S Ferreira, Michael J Keiser and Raquel C de Melo Minardi | Summary: Machine learning-based drug discovery success depends on molecular representation. Yet traditional molecular fingerprints omit both the protein and pointers back to structural information […]


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The transcription regulator Lmo3 is required for cell fate specification in the external globus pallidus

Kavli Affiliate: John Rubenstein | Authors: Shiona Biswas, C. Savio Chan, John L.R. Rubenstein and Lin Gan | Summary: The external globus pallidus (Gpe) is an essential component of the basal ganglia, a group of subcortical nuclei that are involved in control of action. Changes in the firing of GPe neurons are associated with both […]


Continue.. The transcription regulator Lmo3 is required for cell fate specification in the external globus pallidus

Hecatomb: An End-to-End Research Platform for Viral Metagenomics

Kavli Affiliate: Robert Edwards | Authors: Michael J. Roach, Sarah Beecroft, Kathie Mihindukulasuriya, Leran Wang, Lais Farias Oliveira Lima, Elizabeth A. Dinsdale, Robert Edwards and Scott Allyn Handley | Summary: Analysis of viral diversity using modern nucleic acid sequencing technologies presents several unique challenges. Foremost being that virus detection requires a non-targeted, random (shotgun) approach. […]


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Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate

Kavli Affiliate: Kira Poskanzer | Authors: Kira Poskanzer, Trisha V Vaidyanathan, Vincent Tse and Esther M Lim | Summary: Astrocytes perform critical functions in the nervous system, many of which are dependent on neurotransmitter-sensing through G protein-coupled receptors (GPCRs). However, whether specific astrocytic outputs follow specific GPCR activity remains unclear, and exploring this question is […]


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TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

Kavli Affiliate:Allan Basbaum | Authors: Wendy W.S. Yue, Lin Yuan, Joao M. Bráz, Allan I. Basbaum and David Julius | Summary: TRPV1, a capsaicin- and heat-sensitive ion channel, is expressed by peripheral nociceptors and has been implicated in various inflammatory and neuropathic pain conditions. Although pharmacological modulation of TRPV1 has attracted therapeutic interest, their utility […]


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Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses

Kavli Affiliate: Saul Kato | Authors: Rashmi Chandra, Fatima Farah, Fernando Munoz-Lobato, Anirudh Bokka, Kelli L Benedetti, Chantal Brueggemann, Fatema Mashel Saifuddin, Julia M. Miller, Joy Li, Eric Chang, Aruna Varshney, Vanessa Jiminez, Anjana Baradwaj, Cibelle Nassif, Sara Alladin, Kristine E Andersen, Veronica Bi, Sarah K Nordquist, Raymond L Dunn, Bryan Tsujimoto, Alan Tran, Alexander […]


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A Spectrum of Time Horizons for Dopamine Signals

Kavli Affiliate: Joshua Berke | Authors: Wei Wei, Ali Mohebi and Joshua Berke | Summary: Dopamine input to striatum can encode reward prediction error, a critical signal for updating predictions of future rewards. However, it is unclear how this mechanism handles the need to make predictions, and provide feedback, over multiple time horizons: from seconds […]


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Deep learning from multiple experts improves identification of amyloid neuropathologies

Kavli Affiliate: Michael Keiser | Authors: Daniel R. Wong, Ziqi Tang, Nicholas C. Mew, Sakshi Das, Justin Athey, Kirsty E. McAleese, Julia K. Kofler, Margaret E. Flanagan, Ewa Borys, Charles L. White III, Atul J Butte, Brittany N Dugger and Michael J. Keiser | Summary: Pathologists can label pathologies differently, making it challenging to yield […]


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Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

Kavli Affiliate: Robert Edwards | Authors: Victoria Stalls, Jared Lindenberger, Sophie Gobeil, Rory Henderson, Rob Parks, Maggie Barr, Margaret Deyton, Mitchell Martin, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, Esther Beaudoin, Robert J Edwards, Amanda Eaton, David Montefiori, Wilton Williams, Kevin O’Neil Saunders, Kevin Wiehe, Barton F Haynes and Priyamvada Acharya | Summary: The […]


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Long-range inhibition synchronizes and updates prefrontal task activity

Kavli Affiliate: Vikaas Sohal | Authors: Kathleen Cho, Jingcheng Shi and Vikaas Singh Sohal | Summary: Changes in patterns of activity within the medial prefrontal cortex enable rodents, non-human primates, and humans to update their behavior to adapt to changes in the environment, e.g., during cognitive tasks1–5. Within medial prefrontal cortex, inhibitory neurons expressing parvalbumin […]


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