Kavli Affiliate: David Rowitch | Authors: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein and Amanda Brosius Lutz | Summary: The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing […]

Kavli Affiliate: Noelle Letoile, Saul Kato | Authors: Kelli L. Benedetti, Fatema A Saifuddin, Julia M Miller, Kevin Daigle, Rashmi Chandra, Alec Chen, Christine Lin, Angel Jacob Garcia, Burhanuddin Calcuttawala, Angelica Tovar, Raymond L Dunn, Jackson Borchardt, Julia A Kaye, Bo Zhang, Saul Kato, Maria E Gallegos, Torsten Wittmann and Noelle L’Etoile | Summary: SUMMARY […]

Kavli Affiliate: Michael Brainard | Authors: Bradley M Colquitt, Kelly Li, Foad Green, Robert J Veline and Michael S Brainard | Summary: SUMMARY Sensory feedback is required for stable execution of learned motor skills, and its loss can severely disrupt motor performance. The neural mechanisms that mediate sensorimotor stability have been extensively studied at systems […]

Kavli Affiliate: Daniel Minor | Authors: Daniel L Minor, Jr., Zhou Chen and Abhisek Mondal | Summary: Abstract Gabapentinoid drugs for pain and anxiety act on the CaVα2δ-1 and CaVα2δ-2 subunits of high-voltage activated calcium channels (CaV1s and CaV2s). Here, we present the cryo-EM structure of the gabapentin-bound brain and cardiac CaV1.2/CaVβ3/CaVα2δ-1 channel. The data […]

Kavli Affiliate: Kristofer Bouchard | Authors: Jiali Lu, Sumithra Surendralal, Kristofer E Bouchard and Dezhe Z. Jin | Summary: Abstract Songs of the Bengalese finch consist of variable sequences of syllables. The sequences follow probabilistic rules, and can be statistically described by partially observable Markov models (POMMs), which consist of states and probabilistic transitions between […]

Kavli Affiliate: Edward Chang, Vikaas Sohal | Authors: Adam Jackson, Josh Cohen, Aarron Phensy, Edward F Chang, Heather Dawes and Vikaas Sohal | Summary: ABSTRACT Emotional responses arise from limbic circuits including the hippocampus and amygdala. In the human brain, beta-frequency communication between these structures correlates with self-reported mood and anxiety. However, both the mechanism […]

Kavli Affiliate: Joshua Berke | Authors: Ali Mohebi, Val L Collins and Joshua D Berke | Summary: Abstract Motivation to work for potential rewards is critically dependent on dopamine (DA) in the nucleus accumbens (NAc). DA release from NAc axons can be controlled by at least two distinct mechanisms: 1) action potentials propagating from DA […]

Kavli Affiliate: Noelle Letoile | Authors: Evangeline Chien, Angel Jacob Garcia, Noelle L’Etoile and RASHMI CHANDRA | Summary: Abstract While astrocytes are known to be important for development and nourishment of the nervous system, the field is just beginning to explore how astrocytes respond to environmental stimuli. Using Caenorhabditis elegans and their astrocyte-equivalent, CEPsh, we […]

Kavli Affiliate: Noelle Letoile | Authors: Evangeline Chien, Angel Jacob Garcia, RASHMI CHANDRA and Noelle L’Etoile | Summary: Abstract While astrocytes are known to be important for development and nourishment of the nervous system, the field is just beginning to explore how astrocytes respond to environmental stimuli. Using Caenorhabditis elegans and their astrocyte-equivalent, CEPsh, we […]

Kavli Affiliate: Noelle Letoile | Authors: Evangeline Chien, Angel Jacob Garcia, Noelle L’Etoile and RASHMI CHANDRA | Summary: Abstract While astrocytes are known to be important for development and nourishment of the nervous system, the field is just beginning to explore how astrocytes respond to environmental stimuli. Using Caenorhabditis elegans and their astrocyte-equivalent, CEPsh, we […]