Defective callosal termination underlies the long-term behavioral deficits in NMDA receptor antibody encephalitis mouse model

Kavli Affiliate: Samuel Pleasure | Authors: Jing Zhou, Ariele Greenfield, Rita Loudermilk, Christopher Bartley, Baouyen Tran, Chao Zhao, Hong Wang, Michael Wilson and Samuel Pleasure | Summary: NMDA receptor antibody encephalitis (NMDAR-AE) is characterized by cerebrospinal fluid (CSF)-resident anti-NMDA receptor autoantibodies that cause a wide range of neurological manifestations. Although many symptoms are responsive to […]


Continue.. Defective callosal termination underlies the long-term behavioral deficits in NMDA receptor antibody encephalitis mouse model

Dual credit assignment processes underlie dopamine signals in a complex spatial environment

Kavli Affiliate: Joshua Berke, Loren Frank | Authors: Timothy Amos Krausz, Alison E. Comrie, Loren M. Frank, Nathaniel Douglass Daw and Joshua D. Berke | Summary: Dopamine in the nucleus accumbens helps motivate behavior based on expectations of future reward (“values”). These values need to be updated by experience: after receiving reward, the choices that […]


Continue.. Dual credit assignment processes underlie dopamine signals in a complex spatial environment

A systematic search for RNA structural switches across the human transcriptome

Kavli Affiliate: Yifan Cheng | Authors: Matvei Khoroshkin, Daniel Asarnow, Albertas Navickas, Aidan Winters, Johnny Yu, Simon K. Zhou, Shaopu Zhou, Christina Palka, Lisa Fish, K. Mark Ansel, Yifan Cheng, Luke A. Gilbert and Hani Goodarzi | Summary: RNA structural switches are key regulators of gene expression in bacteria, yet their characterization in Metazoa remains […]


Continue.. A systematic search for RNA structural switches across the human transcriptome

Novel crAssphage isolates exhibit conserved gene order and purifying selection of the host specificity protein

Kavli Affiliate: Robert Edwards | Authors: Bhavya Papudeshi, Alejandro A Vega, Cole Souza, Sarah K Giles, Vijini Mallawaarachchi, Michael J. Roach, Michelle An, Nicole Jacobson, Katelyn McNair, Maria Fernanda Mora, Karina Pastrana, Christopjer Leigh, Clarice Cram, Will S Plewa, Susanna R Grigson, George Bouras, Przemyslaw Decewicz, Antoni Luque, Lindsay Droit, Scott Allyn Handley, Anca Segall, […]


Continue.. Novel crAssphage isolates exhibit conserved gene order and purifying selection of the host specificity protein

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

Kavli Affiliate: Robert Edwards | Authors: Kevin Saunders, James Counts, Victoria Stalls, Robert Edwards, Kartik Manne, Xiaozhi Lu, Bhishem Thakur, Katayoun Mansouri, Yue Chen, Rob Parks, Maggie Barr, Laura Sutherland, Joena Bal, Nicholas Havill, Haiyan Chen, Emily Machiele, Nolan Jamieson, Bhavna Hora, Megan Kopp, Katarzyna Janowska, Kara Anasti, Chuancang Jiang, Sravani Venkatayogi, Amanda Eaton, Rory […]


Continue.. Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

Inhibitory control of speech production in the human premotor frontal cortex

Kavli Affiliate: Edward Chang | Authors: Lingyun Zhao, Alexander B. Silva, Garret L. Kurteff and Edward F. Chang | Summary: Natural speech is full of starts and stops. Here, we studied the neural mechanisms that underlie the inhibitory control of speech, specifically the ability to stop speaking on demand. We recorded direct cortical activity while […]


Continue.. Inhibitory control of speech production in the human premotor frontal cortex

Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis

Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Jiwen Li, Marlesa I. Godoy, Alice J. Zhang, Graciel Diamante, In Sook Ahn, Arantxa Cebrian-Silla, Arturo Alvarez-Buylla, Xia Yang, Bennett G. Novitch and Ye Zhang | Summary: Embryonic neural stem cells (NSCs, i.e., radial glia) in the ventricular-subventricular zone (V-SVZ) generate the majority of neurons and glia in the […]


Continue.. Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis

Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex

Kavli Affiliate: Alex Pollen | Authors: Chengyu Deng, Sean Whalen, Marilyn Steyert, Ryan Ziffra, Pawel F Przytycki, Fumitaka Inoue, Daniela Alves Pereira, Davide Capauto, Scott Norton, Flora M. Vaccarino, Alex Aaron Pollen, Tomasz J. Nowakowski, Nadav Ahituv and Katherine S. Pollard | Summary: Nucleotide changes in gene regulatory elements are important determinants of neuronal development […]


Continue.. Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex

Vulture: Cloud-enabled scalable mining of microbial reads in public scRNA-seq data

Kavli Affiliate: Xin Duan | Authors: Junyi Chen, Danqing Yin, Harris Y. H. Wong, Xin Duan, Ken H. O. Yu and Joshua W. K. Ho | Summary: The rapidly growing collection of public single-cell sequencing data have become a valuable resource for molecular, cellular and microbial discovery. Previous studies mostly overlooked detecting pathogens in human […]


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The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex

Kavli Affiliate: Arturo Alvarez-Buylla, Andrea Hasenstaub, Michael Stryker | Authors: Walter R Mancia Leon, David M Steffen, Fiona Dale-Huang, Benjamin Rakela, Arnar Breevoort, Ricardo Romero-Rodriguez, Andrea R Hasenstaub, Michael P Stryker, Joshua A Weiner and Arturo Alvarez-Buylla | Summary: Cortical function critically depends on inhibitory/excitatory balance. Cortical inhibitory interneurons (cINs) are born in the ventral […]


Continue.. The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex