Inhibitory control of speech production in the human premotor frontal cortex

Kavli Affiliate: Edward Chang | Authors: Lingyun Zhao, Alexander B. Silva, Garret L. Kurteff and Edward F. Chang | Summary: Natural speech is full of starts and stops. Here, we studied the neural mechanisms that underlie the inhibitory control of speech, specifically the ability to stop speaking on demand. We recorded direct cortical activity while […]


Continue.. Inhibitory control of speech production in the human premotor frontal cortex

Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis

Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Jiwen Li, Marlesa I. Godoy, Alice J. Zhang, Graciel Diamante, In Sook Ahn, Arantxa Cebrian-Silla, Arturo Alvarez-Buylla, Xia Yang, Bennett G. Novitch and Ye Zhang | Summary: Embryonic neural stem cells (NSCs, i.e., radial glia) in the ventricular-subventricular zone (V-SVZ) generate the majority of neurons and glia in the […]


Continue.. Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis

Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex

Kavli Affiliate: Alex Pollen | Authors: Chengyu Deng, Sean Whalen, Marilyn Steyert, Ryan Ziffra, Pawel F Przytycki, Fumitaka Inoue, Daniela Alves Pereira, Davide Capauto, Scott Norton, Flora M. Vaccarino, Alex Aaron Pollen, Tomasz J. Nowakowski, Nadav Ahituv and Katherine S. Pollard | Summary: Nucleotide changes in gene regulatory elements are important determinants of neuronal development […]


Continue.. Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex

Vulture: Cloud-enabled scalable mining of microbial reads in public scRNA-seq data

Kavli Affiliate: Xin Duan | Authors: Junyi Chen, Danqing Yin, Harris Y. H. Wong, Xin Duan, Ken H. O. Yu and Joshua W. K. Ho | Summary: The rapidly growing collection of public single-cell sequencing data have become a valuable resource for molecular, cellular and microbial discovery. Previous studies mostly overlooked detecting pathogens in human […]


Continue.. Vulture: Cloud-enabled scalable mining of microbial reads in public scRNA-seq data

The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex

Kavli Affiliate: Arturo Alvarez-Buylla, Andrea Hasenstaub, Michael Stryker | Authors: Walter R Mancia Leon, David M Steffen, Fiona Dale-Huang, Benjamin Rakela, Arnar Breevoort, Ricardo Romero-Rodriguez, Andrea R Hasenstaub, Michael P Stryker, Joshua A Weiner and Arturo Alvarez-Buylla | Summary: Cortical function critically depends on inhibitory/excitatory balance. Cortical inhibitory interneurons (cINs) are born in the ventral […]


Continue.. The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex

Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes

Kavli Affiliate: Saul Kato | Authors: Morgan M Stanton, Sara Modan, Patrick M Taylor, Harsh N Hariani, Jordan Sorokin, Brian G Rash, Sneha B Rao, Alejandro Lopez-Tobon, Luigi Enriquez, Brenda Dang, Dorah Owango, Shannon O’Neill, Carlos Castrillo, Justin Nicola, Kathy Ye, Robert M Blattner, Federico Gonzalez, Dexter Antonio, Pavan Ramkumar, Andy Lash, Douglas Flanzer, Sophia […]


Continue.. Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes

Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels

Kavli Affiliate: Michael Keiser | Authors: Daniel R. Wong, Shino D. Magaki, Harry V. Vinters, William H. Yong, Edwin S. Monuki, Christopher K. Williams, Alessandra C. Martini, Charles DeCarli, Chris Khacherian, John P. Graff, Brittany N. Dugger and Michael J. Keiser | Summary: Precise, scalable, and quantitative evaluation of whole slide images is crucial in […]


Continue.. Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Kavli Affiliate: David Rowitch | Authors: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein and Amanda Brosius Lutz | Summary: The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing […]


Continue.. Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

The TRPV Channel OSM-9 is Required for Sleep-Dependent Olfactory Memory and is Expressed in Sensory Neurons That Typically Do Not Promote Butanone Attraction

Kavli Affiliate: Noelle Letoile, Saul Kato | Authors: Kelli L. Benedetti, Fatema A Saifuddin, Julia M Miller, Kevin Daigle, Rashmi Chandra, Alec Chen, Christine Lin, Angel Jacob Garcia, Burhanuddin Calcuttawala, Angelica Tovar, Raymond L Dunn, Jackson Borchardt, Julia A Kaye, Bo Zhang, Saul Kato, Maria E Gallegos, Torsten Wittmann and Noelle L’Etoile | Summary: SUMMARY […]


Continue.. The TRPV Channel OSM-9 is Required for Sleep-Dependent Olfactory Memory and is Expressed in Sensory Neurons That Typically Do Not Promote Butanone Attraction

Neural circuit-wide analysis of gene expression during deafening-induced destabilization of birdsong

Kavli Affiliate: Michael Brainard | Authors: Bradley M Colquitt, Kelly Li, Foad Green, Robert J Veline and Michael S Brainard | Summary: SUMMARY Sensory feedback is required for stable execution of learned motor skills, and its loss can severely disrupt motor performance. The neural mechanisms that mediate sensorimotor stability have been extensively studied at systems […]


Continue.. Neural circuit-wide analysis of gene expression during deafening-induced destabilization of birdsong