Kavli Affiliate: Robert Edwards | Authors: Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei, Min Hu, Anna Casasent, Aatish Thennavan, Jianzhuo Li, Tuan Tran, Ken Chen, Benedikt Nilges, Nachiket Kashikar, Oliver Braubach, Bassem Cheikh, Nadya Nikulina, Hui Chen, Mediate Teshome, Brian Menegaz, Huma […]
Kavli Affiliate: Robert Edwards | Authors: Jody C McKerral, Bhavya Nalagampalli Papudeshi, Laura K Inglis, Michael J Roach, Przemyslaw Decewicz, Katelyn McNair, Antoni Luque, Elizabeth A Dinsdale and Robert A Edwards | Summary: Phages dominate every ecosystem on the planet. While virulent phages sculpt the microbiome by killing their bacterial hosts, temperate phages provide unique […]
Kavli Affiliate: Kevin Bender | Authors: Anna M Lipkin and Kevin J Bender | Summary: Neurons are remarkably polarized structures: dendrites spread and branch to receive synaptic inputs while a single axon extends and transmits action potentials to downstream targets. Neuronal polarity is maintained by the axon initial segment (AIS), a region between the soma […]
Kavli Affiliate: Robert Edwards | Authors: Morgan M Stanton, Harsh N Hariani, Jordan Sorokin, Patrick M Taylor, Sara Modan, Brian G Rash, Sneha B Rao, Luigi Enriquez, Daphne Quang, Pei-Ken Hsu, Justin Paek, Dorah Owango, Carlos Castrillo, Justin Nicola, Pavan Ramkumar, Andy Lash, Douglas Flanzer, Kevan Shah, Saul Kato and Gaia Skibinski | Summary: Human-derived […]
Kavli Affiliate: Robert Edwards | Authors: Katelyn McNair, Peter Salamon, Robert A. Edwards and Anca M. Segall | Summary: One of the stranger phenomena that can occur during gene translation is where, as a ribosome reads along the mRNA, various cellular and molecular properties contribute to stalling the ribosome on a slippery sequence, shifting the […]
Kavli Affiliate: Seth Shipman | Authors: Sierra K Lear, Jose A Nunez and Seth L Shipman | Summary: Efficient metabolic engineering and the development of mitochondrial therapeutics often rely upon the specific and strong import of foreign proteins into mitochondria. Fusing a protein to a mitochondria-bound signal peptide is a common method to localize proteins […]
Kavli Affiliate: Yuh Nung Jan, Lily Jan | Authors: Sami Tapio Tuomivaara, Chin Fen Teo, Yuh Nung Jan, Lily Y Jan and Arun Paul Wiita | Summary: To facilitate our understanding of the often rapid and nuanced dynamics of extracellularly exposed proteomes during signaling events, it is important to devise robust workflows affording fast time […]
Kavli Affiliate: Alex Pollen | Authors: Richard She, Tyler Fair, Nathan K. Schaefer, Reuben A. Saunders, Bryan J Pavlovic, Jonathan S. Weissman and Alex A. Pollen | Summary: Comparative studies of great apes provide a window into our evolutionary past, but the extent and identity of cellular differences that emerged during hominin evolution remain largely […]
Kavli Affiliate: Samuel Pleasure | Authors: Jing Zhou, Ariele Greenfield, Rita Loudermilk, Christopher Bartley, Baouyen Tran, Chao Zhao, Hong Wang, Michael Wilson and Samuel Pleasure | Summary: NMDA receptor antibody encephalitis (NMDAR-AE) is characterized by cerebrospinal fluid (CSF)-resident anti-NMDA receptor autoantibodies that cause a wide range of neurological manifestations. Although many symptoms are responsive to […]
Kavli Affiliate: Joshua Berke, Loren Frank | Authors: Timothy Amos Krausz, Alison E. Comrie, Loren M. Frank, Nathaniel Douglass Daw and Joshua D. Berke | Summary: Dopamine in the nucleus accumbens helps motivate behavior based on expectations of future reward (“values”). These values need to be updated by experience: after receiving reward, the choices that […]