Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking

Posted by klaurent UCSF

Kavli Affiliate: Yifan Cheng | Authors: Un Seng Chio, Eugene Palovcak, Anton A. A. Autzen, Henriette E. Autzen, Elise N. Munoz, Zanlin Yu, Feng Wang, David A. Agard, Jean-Paul Armache, Geeta Narlikar and Yifan Cheng | Summary: Single-particle cryo-EM is widely used to determine enzyme-nucleosome complex structures. However, cryo-EM sample preparation remains challenging and inconsistent […]


Continue.. Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking

Generative models inferred using statistical tests reveal context-dependent syllable transitions in Bengalese finch songs

Posted by klaurent UCSF

Kavli Affiliate: Kristofer Bouchard | Authors: Jiali Lu, Sumithra Surendralal, Kristofer E Bouchard and Dezhe Z. Jin | Summary: Generative models are widely used in modeling sequences from language to birdsong. Here we show that a statistical test designed to guard against overgeneralization of a model in generating sequences can be used to infer minimal […]


Continue.. Generative models inferred using statistical tests reveal context-dependent syllable transitions in Bengalese finch songs

Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Nisha Dhanushkodi, Swayam Prakash, Afshana Quadiri, Latifa Zayou, Ruchi Srivastava, Amin Mohammed Shaik, Berfin Suzer, Izabela Coimbra Ibraim, Gary Landucci, Delia F Tifrea, Mahmoud Singer, Leila Jamal, Robert A Edwards, Hawa Vahed, Lawrence Brown and LBACHIR BENMOHAMED | Summary: Significance SARS-CoV-2 Variants of Concern (VOCs) continue to evolve and […]


Continue.. Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

The Neonatal Gyrencephalic Cortex Maintains Regionally Distinct Streams of Neuroblasts

Posted by klaurent UCSF

Kavli Affiliate: David Rowitch | Authors: Jaeyeon Kim, Kadellyn Sandoval, Aunoy Poddar, Julia Chu, Emma Horton, Di Cui, Keira Nakamura, Theresa Bartels, Christian Wood, David H Rowitch, Hosung Kim, Chet C Sherwood, Boris W Kramer, Angela C Roberts, PABLO J ROSS, Duan Xu, Nicola J Robertson, Peng Ji, Elizabeth A Maga and Mercedes F Paredes […]


Continue.. The Neonatal Gyrencephalic Cortex Maintains Regionally Distinct Streams of Neuroblasts

Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD

Posted by klaurent UCSF

Kavli Affiliate: Kevin Bender | Authors: Chenyu Wang, Kimberly D Derderian, Elizabeth Hamada, Xujia Zhou, Andrew D Nelson, Henry Kyoung, Nadav Ahituv, Guy Bouvier and Kevin Bender | Summary: Children diagnosed with autism spectrum disorder (ASD) commonly present with sensory hypersensitivity, or abnormally strong reactions to sensory stimuli. Such hypersensitivity can be overwhelming, causing high […]


Continue.. Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD

Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.

Posted by klaurent UCSF

Kavli Affiliate: John Rubenstein | Authors: Siavash Fazel Darbandi, Joon Yong An, Kenneth Lim, Nicholas F. Page, Lindsay Liang, Athena Ypsilanti, Eirene Markenscoff-Papadimitriou, Matthew W. State, Alex S Nord, Stephan J. Sanders and John L.R. Rubenstein | Summary: SUMMARY Many autism spectrum disorder (ASD)-associated genes act as transcriptional regulators (TRs). ChIP-seq was used to identify […]


Continue.. Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.

Contrasting synaptic roles of MDGA1 and MDGA2

Posted by klaurent UCSF

Kavli Affiliate: Roger Nicoll | Authors: Michael A. Bemben, Matthew A. Sandoval, Aliza A. Le, Sehoon Won, Vivian N Chau, Julie C. Lauterborn, Salvatore Incontro, Kathy H. Li, Alma L. Burlingame, Katherine W. Roche, Christine M. Gall, Roger A. Nicoll and Javier Diaz-Alonso | Summary: Neurodevelopmental disorders are frequently linked to mutations in synaptic organizing […]


Continue.. Contrasting synaptic roles of MDGA1 and MDGA2

Cross-Protection Induced by Highly Conserved Human B, CD4+, and CD8+ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Swayam Fnu Prakash, Nisha R Dhanushkodi, Latifa Zayou, Izabela Coimbra Ibraim, Afshana Quadiri, Pierre Gregoire Coulon, Delia F Tifrea, Berfin Suzler, Mohamed Amin, Amruth Chilukuri, Robert A Edwards, Hawa Vahed, Anthony B. Nesburn, Baruch D Kuppermann, Jeffrey B Ulmer, Dan Gil, Trevor M Jones and Lbachir BenMohamed | Summary: […]


Continue.. Cross-Protection Induced by Highly Conserved Human B, CD4+, and CD8+ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: David Martinez, Alexandra R. Schaefer, Tyler Gavitt, Michael Mallory, Esther Lee, Nicholas Catanzaro, Haiyan Chen, Kendra Gully, Trevor D. Scobey, Pooja Korategere, Alecia Brown, Lena Smith, Robert Parks, Maggie Barr, Amanda Newman, Cindy Bowman, John M. Powers, Katayoun Mansouri, Robert J Edwards, Ralph S. Baric, Barton Haynes and Kevin […]


Continue.. Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

Molecular recording of calcium signaling via calcium-dependent protein proximity labeling

Posted by klaurent UCSF

Kavli Affiliate: Yuh Nung Jan | Authors: Jungwoo Wren Kim, Adeline J. H. Yong, Erin E. Aisenberg, Ted M. Dawson, Valina L. Dawson, Yuh-Nung Jan, Nicholas T. Ingolia, Wei Wang, Ruixuan Gao and Helen S. Bateup | Summary: Calcium ions serve as key intracellular signals. Local, transient increases in calcium concentrations can activate calcium sensor […]


Continue.. Molecular recording of calcium signaling via calcium-dependent protein proximity labeling