Kavli Affiliate: Edward Chang, Karunesh Ganguly | Authors: NIKHILESH NATRAJ, Sarah Seko, Reza Abiri, Hongyi Yan, Yasmin Graham, Adelyn Tu-Chan, Edward F Chang and Karunesh Ganguly | Summary: The nervous system needs to balance the stability of neural representations with plasticity. It is unclear what is the representational stability of simple actions, particularly those that […]

Kavli Affiliate: Alexandra Nelson, Robert Edwards | Authors: Shweta Jain, Andrew G Yee, James Maas, Sarah Gierok, Hongfei Xu, Jasmine Stansil, Jacob Eriksen, Alexandra Nelson, Katlin Silm, Christopher P Ford and Robert H Edwards | Summary: The burst firing of midbrain dopamine neurons releases a phasic dopamine signal that mediates reinforcement learning. At many synapses, […]

Kavli Affiliate: Seth Shipman | Authors: Manuel Peter, Seth Shipman, Jeffrey D. Macklis | Summary: Differentiation of human pluripotent stem cells (hPSC) into distinct neuronal populations holds substantial potential for disease modeling in vitro, toward both elucidation of pathobiological mechanisms and screening of potential therapeutic agents. For successful differentiation of hPSCs into subtype-specific neurons using […]

Kavli Affiliate: Robert Edwards | Authors: Max Pearson, Carl Haslam, Andrew Fosberry, Emma J Jones, Mark Reglinski, Robert J Edwards, Richard Ashley Lawrenson, Jonathan C Brown, Danuta Mossakowska, James Edward Pease and Shiranee Sriskandan | Summary: The Streptococcus pyogenes cell envelope protease (SpyCEP) is vital to streptococcal pathogenesis and disease progression. Despite its strong association […]

Kavli Affiliate: Robert Edwards | Authors: Camille N. Pierre, Lily E. Adams, Kara Anasti, Derrick Goodman, Sherry Stanfield-Oakley, John M. Powers, Dapeng Li, Wes Rountree, Yunfei Wang, Robert J. Edwards, S. Munir Alam, Guido Ferrari, Georgia D. Tomaras, Barton F. Haynes, Ralph S. Baric and Kevin Saunders | Summary: Antibodies perform both neutralizing and non-neutralizing […]

Kavli Affiliate: Robert Edwards | Authors: Bhavya Papudeshi, Alejandro A Vega, Cole Souza, Sarah K Giles, Vijini Mallawaarachchi, Michael J. Roach, Michelle An, Nicole Jacobson, Katelyn McNair, Maria Fernanda Mora, Karina Pastrana, Lance Boling, Christopjer Leigh, Clarice Cram, Will S Plewa, Susanna R Grigson, George Bouras, Przemyslaw Decewicz, Antoni Luque, Lindsay Droit, Scott Allyn Handley, […]

Kavli Affiliate: Su Guo | Authors: Chee San Tong, Maohan Su, He Sun, Xiang Le Chua, Su Guo, Ravinraj S/O Ramaraj, Ann Gie Lee, Nicole Wen Pei Ong, Yansong Miao and Min Wu | Summary: The coordination between actin and microtubule network is crucial, yet our understanding of the underlying mechanisms remains limited. In this […]

Kavli Affiliate: Seth Shipman | Authors: Alejandro Gonzalez-Delgado, Santiago C Lopez, Matias Rojas-Montero, Chloe B Fishman and Seth L Shipman | Summary: Our understanding of genomics is limited by the scale of our genomic technologies. While libraries of genomic manipulations scaffolded on CRISPR gRNAs have been transformative, these existing approaches are typically multiplexed across genomes. […]

Kavli Affiliate: Andrea Hasenstaub | Authors: David A. McCormick, Yousheng Shu and Andrea R Hasenstaub | Summary: A fundamental feature of the cerebral cortex is the ability to rapidly turn on and off maintained activity within ensembles of neurons through recurrent excitation balanced by inhibition. Here we demonstrate that reduction of the h-current, which is […]

Kavli Affiliate: Kristofer Bouchard, Loren Frank, Christoph Kirst | Authors: Pratik Sachdeva, Ji Hyun Bak, Jesse A Livezey, Loren Frank, Christoph Kirst, Sharmodeep Bhattacharyya and Kristofer Bouchard | Summary: In the brain, all neurons are driven by the activity of other neurons, some of which maybe simultaneously recorded, but most are not. As such, models […]