Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.

Kavli Affiliate: Peter Walter | Authors: Shiqi Diao, Jia Yi Zou, Shuo Wang, Nour Ghaddar, Jason E. Chan, Hyungdong Kim, Nicolas Poulain, Constantinos Koumenis, Maria Hatzoglou, Peter Walter, Nahum Sonenberg, John Le Quesne, Tuomas Tammela and Antonis E. Koromilas | Summary: The link between the “stress phenotype”-a well-established hallmark of cancer-and its role in tumor […]


Continue.. Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.

A lateralized pathway for associating nutrients with flavors

Kavli Affiliate: Zachary Knight | Authors: James C.R. Grove, Queenie Li, Heiko Backes, Bojana Kuzmanovic, Jaewon Choi, Violeta Ubadiah, Longhui Qiu, Jingkun Zhang, Zhengya Liu, Dana M. Small, Marc Tittgemeyer and Zachary A Knight | Summary: Animals learn about the external world, in part, via interoceptive signals1,2. For example, the nutrient content of food is […]


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A Generalist Intracortical Motor Decoder

Kavli Affiliate: Kristofer Bouchard | Authors: Joel Ye, Fabio Rizzoglio, Adam Smoulder, Hongwei Mao, Xuan Ma, Patrick Marino, Raeed H Chowdhury, Dalton D Moore, Gary Blumenthal, Will Hockeimer, Nicolas G. Kunigk, J Patrick Mayo, Aaron P Batista, Steven M Chase, Adam G Rouse, Michael L. Boninger, Charles Greenspon, Andrew B. Schwartz, Nicholas Hatsopoulos, Lee E […]


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Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics

Kavli Affiliate: Michael Keiser | Authors: Parker Grosjean, Kaivalya Shevade, Cuong Nguyen, Sarah Ancheta, Karl Mader, Ivan Franco, Seok-Jin Heo, Greyson Lewis, Steven Boggess, Angelique De Domenico, Erik Ullian, Shawn Shafer, Adam Litterman, Laralynne Przybyla, Michael J Keiser, Jamie Ifkovits, Adam Yala and Martin Kampmann | Summary: High-throughput phenotypic screening has historically relied on manually […]


Continue.. Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics

Phage defense and genome editing using novel retrons sourced from isolated environmental bacteria

Kavli Affiliate: Seth Shipman | Authors: Kazuo Nakamura, Karen Zhang, Mario R Mestre, Matias Rojas-Montero and Seth Shipman | Summary: Retrons are bacterial immune systems that protect a bacterial population against phages by killing infected hosts. Retrons typically comprise a reverse transcriptase, a template noncoding RNA that is partially reverse transcribed into RT-DNA, and a […]


Continue.. Phage defense and genome editing using novel retrons sourced from isolated environmental bacteria

Non-Visual Light Sensing Enhances Behavioral Memory and Drives Gene Expression in C. elegans

Kavli Affiliate: Noelle L’Etoile | Authors: Zhijian Ji, Bingying Wang, Junqiang Liu, Rashmi K. Chandra, Winnie Yang, Yong Long, Michael Egan, Noelle L’Etoile and Dengke K. Ma | Summary: Visible light influences a range of physiological processes, yet how animals respond to it independently of the visual system remains largely unknown. Here, we uncover a […]


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Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity

Kavli Affiliate: Robert Edwards | Authors: Parker J. Jamieson, Xiaoying Shen, Alexandra A. Abu-Shmais, Perry T. Wasdin, Katarzyna Janowska, Robert J. Edwards, Garrett Scapellato, Simone I. Richardson, Nelia P. Manamela, Shuying Liu, Maggie Barr, Rebecca A. Gillespie, Jessica Mimms, Naveenchandra Suryadevara, Ty A. Sornberger, Seth Zost, Rob Parks, Shelby Flaherty, Alexis K. Janke, Bethany N. […]


Continue.. Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity

Integration of Transplanted Interneurons Over a New Period of Ocular Dominance Plasticity in Adult Mouse Visual Cortex

Kavli Affiliate: Arturo Alvarez-Buylla, Andrea Hasenstaub, and Michael Stryker | Authors: Benjamin Rakela, Jennifer Sun, Philine Marchetta, Arturo Alvarez-Buylla, Andrea R Hasenstaub and Michael P Stryker | Summary: Cortical interneurons play an important role in mediating the juvenile critical period for ocular dominance plasticity in the mouse primary visual cortex. Previously, we showed that transplantation […]


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WormID-Benchmark: Extracting Whole-Brain Neural Dynamics of C. elegans At the Neuron Resolution

Kavli Affiliate: Saul Kato | Authors: Jason Adhinarta, Jizheng Dong, Tianxiao He, Daniel Sprague, JIa Wan, Hyun Jee Lee, Zikai Yu, Hang Lu, Eviatar Yemini, Saul Kato, Erdem Varol and Donglai Wei | Summary: The nematode C. elegans is a well-studied model organism for characterizing the structure, connectivity, and function of a complete nervous system. […]


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Pathological microcircuits initiate epileptiform events in patient hippocampal slices

Kavli Affiliate: Edward Chang | Authors: Matthew Elliott, John P. Andrews, Tjitse van der Molen, Jinghui Geng, Alex Spaeth, Anna Toledo, Kateryna Voitiuk, Cordero Core, Thomas Gillespie, Ari Sinervo, David F. Parks, Ash Robbins, Daniel Solis, Edward F. Chang, Tomasz J Nowakowski, Mircea Teodorescu, David Haussler and Tal Sharf | Summary: How seizures begin at […]


Continue.. Pathological microcircuits initiate epileptiform events in patient hippocampal slices