Heterocellular and homocellular electrically coupled networks of the thalamus and cortex revealed by focal photomapping

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Kevin Bender | Authors: Mitchell J. Vaughn, Kevin J. Bender and Julie S. Haas | Summary: Electrical synapses are present widely across the mammalian brain and are crucial components of active neural circuitry and connectomes. Identification of electrically coupled networks in living tissue has been limited by technical demands of multiplexed recordings, and […]


Continue.. Heterocellular and homocellular electrically coupled networks of the thalamus and cortex revealed by focal photomapping

Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

Posted by dbos UCSF

Kavli Affiliate: Alexandra Nelson and Anatol Kreitzer | Authors: Katerina L Rademacher, Zak Doric, Dominik Haddad, Aphroditi Mamaligas, Szu-Chi Liao, Rose Creed, Kohei Kano, Zac Chatterton, Yuhong Fu, Joseph H Garcia, Victoria Vance, Yoshitaka Sei, Anatol Kreitzer, Glenda Halliday, Alexandra Nelson, Elyssa Margolis and Ken L Nakamura | Summary: Parkinson’s disease (PD) is characterized by […]


Continue.. Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

Mapping the ISR Landscape in Cognitive Disorders via single-cell multi-omics

Posted by dbos UCSF

Kavli Affiliate: Peter Walter | Authors: Kristof Torkenczy, Lucas C Reineke, Sean W Dooling, Benjamin W Henderson, Daniel Itzhak, Benjamin Yang, Dongze He, Richard M Myers, Peter Walter, Stefka Tyanova and Mauro Costa-Mattioli | Summary: Persistent activation of the integrated stress response (ISR) is a major driver of cognitive decline in both neurodevelopmental and neurodegenerative […]


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Deconvolution to restore cryo-EM maps with anisotropic resolution

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Junrui Li, Yifei chen, Shawn Zheng, Angus McDonald, John W. Sedat, David A. Agard and Yifan Cheng | Summary: With technological advancements in recent years, single particle cryogenic electron microscopy (cryo-EM) has become a major methodology for structural biology. Structure determination by single particle cryo-EM is premised on randomly […]


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Extracellular matrix proteolysis maintains synapse plasticity during brain development

Posted by dbos UCSF

Kavli Affiliate: Anna Molofsky and Christoph Kirst | Authors: Haruna Nakajo, Ran Cao, Supriya A. Mula, Justin McKetney, Nicholas J. Silva, Muskaan Shah, Indigo V.L. Rose, Martin Kampmann, Danielle L. Swaney, Christoph Kirst and Anna V. Molofsky | Summary: Maintaining a dynamic neuronal synapse pool is critical to brain development. The extracellular matrix (ECM) regulates […]


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Data-driven fine-grained region discovery in the mouse brain with transformers

Posted by dbos UCSF

Kavli Affiliate: Reza Abbasi Asl | Authors: Alex Jihun Lee, Shenqin Yao, Nicholas Lusk, Hongkui Zeng, Bosiljka Tasic and Reza Abbasi-Asl | Summary: Spatial transcriptomics offers unique opportunities to define the spatial organization of tissues and organs, such as the mouse brain. We address a key bottleneck in the analysis of organ-scale spatial transcriptomic data […]


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Structural and Antigenic Characterization of Novel and Diverse Henipavirus Glycoproteins

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Aaron J. May, Muralikrishna Lella, Jared Lindenberger, Alex Berkman, Ujjwal Kumar, Moumita Dutta, Maggie Barr, Rob Parks, Amanda Newman, Xiao Huang, Kijun Song, Victor Ilevbare, Salam Sammour, Chan Soo Park, Radha Devkota Adhikari, Priyanka Devkota, Katarzyna Janowska, Yanshun Liu, Garrett Scapellato, Taylor N. Spence, Katayoun Mansouri, Robert J Edwards, […]


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Human precentral gyrus neurons link speech sequences from listening to speaking

Posted by dbos UCSF

Kavli Affiliate: Edward Chang | Authors: Duo Xu, Jason E Chung, Alexander B Silva, Quinn R Greicius, Sean L Metzger, Yizhen Zhang, Matthew K Leonard, Manish K Aghi, Shawn L Hervey-Jumper and Edward F Chang | Summary: Speech perception and production are interconnected processes, but the underlying neural mechanisms remain unclear. We investigated this relationship […]


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Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.

Posted by dbos UCSF

Kavli Affiliate: Peter Walter | Authors: Shiqi Diao, Jia Yi Zou, Shuo Wang, Nour Ghaddar, Jason E. Chan, Hyungdong Kim, Nicolas Poulain, Constantinos Koumenis, Maria Hatzoglou, Peter Walter, Nahum Sonenberg, John Le Quesne, Tuomas Tammela and Antonis E. Koromilas | Summary: The link between the “stress phenotype”-a well-established hallmark of cancer-and its role in tumor […]


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A lateralized pathway for associating nutrients with flavors

Posted by dbos UCSF

Kavli Affiliate: Zachary Knight | Authors: James C.R. Grove, Queenie Li, Heiko Backes, Bojana Kuzmanovic, Jaewon Choi, Violeta Ubadiah, Longhui Qiu, Jingkun Zhang, Zhengya Liu, Dana M. Small, Marc Tittgemeyer and Zachary A Knight | Summary: Animals learn about the external world, in part, via interoceptive signals1,2. For example, the nutrient content of food is […]


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