Kavli Affiliate: Robert Edwards | Authors: Hannelore Longin, George Bouras, Susanna R. Grigson, Robert A. Edwards, Hanne Hendrix, Rob Lavigne and Vera van Noort | Summary: Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, to date, only a […]
Kavli Affiliate: Noelle L’Etoile | Authors: Zhijian Ji, Bingying Wang, Junqiang Liu, Rashmi K. Chandra, Winnie Yang, Yong Long, Michael Egan, Noelle L’Etoile and Dengke K. Ma | Summary: Visible light influences a range of physiological processes, yet how animals respond to it independently of the visual system remains largely unknown. Here, we uncover a […]
Kavli Affiliate: Seth Shipman | Authors: Alejandro Gonzalez-Delgado, Laura Bonillo-Lopez, Milo S Johnson, Nastassia Knoedlseder, Ching-Chung Ko, Yassir Lekbach, Jee-Hwan Oh, Hemaa Selvakumar, Michael C Wold, Zihan Yu, Virginia Aragon, Jeffrey A Gralnick, Marc Guell, Graham Hatfull, Benjamin Keith Keitz, Britt Koskella, Vivek K Mutalik, Jan Peter van Pijkeren and Seth Shipman | Summary: Advanced […]
Kavli Affiliate: Edward Chang | Authors: Vardhaan S Ambati, Amit S Persad, Jasleen Kaur, Sanjeev Herr, Emily Cunningham, Abraham Dada, Justyna O Ekert, Quinn Greicius, Alexander Silva, Paul McMillan Villalobos, Niels Olshausen, Youssef Sibih, Sena Oten, Hunter S. Yamada, Gray Umbach, Alexander A Aabedi, Wajd Al-Holou, Jacob Young, Madhumita Sushil, Edward F Chang, Mitchel S. […]
Kavli Affiliate: Su Guo | Authors: Krishnashish Bose, Su Guo and Karnika Bhardwaj | Summary: Paradoxical kinesia—the temporary alleviation of motor deficits by powerful, urgent stimuli in Parkinson’s disease (PD)—remains poorly understood at the neural circuit level. Through chemo-genetic ablation of tyrosine hydroxylase-expressing neurons in larval zebrafish and brain-wide calcium imaging under head-fixed, tail-free conditions, […]
Kavli Affiliate: Jeanne Paz | Authors: Jeremy B Ford, Olive N Tambou, Jarret AP Weinrich, Debleena Chatterjee, Allan Basbaum and Jeanne T. Paz | Summary: Central post-stroke pain (CPSP) is a highly distressing condition that develops in 50% of people who suffer a thalamic stroke, and is typically unresponsive to current clinical treatments. Hypoxic damage […]
Kavli Affiliate: Vikaas Sohal | Authors: Xiyu Zhu, Lara L. Hagopian, Kira E. Wallquist and Vikaas Singh Sohal | Summary: While glutamatergic synaptic plasticity is believed to be a fundamental mechanism mediating learning, the behavioral significance of plasticity at cortical GABAergic synapses remains less well understood. Furthermore, despite recent discoveries of long-range projections from neocortical […]
Kavli Affiliate: Lily Jan and Yuh Nung Jan | Authors: Chin Fen Teo, Sami T Tuomivaara, Niek van Hilten, David Crottès, Yuh Nung Jan, Michael Grabe and Lily Y Jan | Summary: The asymmetric resting distribution of the three major phospholipid classes on the mammalian plasma membrane, with phosphatidylserine and phosphatidylethanolamine mostly on the inner […]
Kavli Affiliate: Arnold R. Kriegstein | Authors: Tianzhi Wu, lihua jiang, Tanzila Mukhtar, Li Wang, ruiqi jian, Cheng Wang, Tiffany Trinh, Arnold Kriegstein, Michael Snyder and Jingjing Li | Summary: Proteins are the functional effectors of virtually all biological processes, and accurately measuring their abundance and dynamics is essential for understanding development and disease. Although […]
Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Bart A Eijkelkamp, Timothy R Cavagnaro, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Garth Harmsworth, Damien J Keating, Robert A Edwards and Martin F Breed | Summary: The global rise in human allergic and autoimmune diseases is linked to altered environmental microbiome exposures from increasing […]