Long-term effects of psilocybin on dynamic and effectivity connectivity of fronto-striatal-thalamic circuits

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Adam Gazzaley | Authors: Lorenzo Pasquini, Jakub Vohryzek, Anira Escrichs, Yonatan Sanz Perl, Adrian Ponce-Alvarez, Sebastian Idesis, Manesh Girn, Leor Roseman, Jennifer M Mitchell, Adam Gazzaley, Morten Kringelbach, David J Nutt, Taylor Lyons, Robin L Carhart-Harris and Gustavo Deco | Summary: Psilocybin has been shown to induce fast and sustained improvements in mental […]


Continue.. Long-term effects of psilocybin on dynamic and effectivity connectivity of fronto-striatal-thalamic circuits

Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Alex Pollen | Authors: Sara Nolbrant, Jenelle L. Wallace, Jingwen Ding, Tianjia Zhu, Jess L. Sevetson, Janko Kajtez, Isabella A. Baldacci, Emily K. Corrigan, Kaylynn Hoglin, Reed McMullen, Matthew T. Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J. Pavlovic, Sofie R. Salama, Agnete Kirkeby, Hao Huang, Nathan K. Schaefer and Alex A. […]


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Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s Disease

Posted by dbos UCSF

Kavli Affiliate: Alexandra Nelson | Authors: Xiaowen Zhuang, Julia Lemak, Sadhana Sridhar and Alexandra B Nelson | Summary: Summary: Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive deficits, this coordination […]


Continue.. Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s Disease

Striatal lateral inhibition regulates action selection in a mouse model of levodopa-induced dyskinesia

Posted by dbos UCSF

Kavli Affiliate: Alexandra Nelson | Authors: Emily L Twedell, Chloe J Bair-Marshall, Allison E Girasole, Lara K Scaria, Sadhana Sridhar and Alexandra B Nelson | Summary: Summary: Striatal medium spiny neurons (MSNs) integrate multiple external inputs to shape motor output. In addition, MSNs form local inhibitory synaptic connections with one another. The function of striatal […]


Continue.. Striatal lateral inhibition regulates action selection in a mouse model of levodopa-induced dyskinesia

Tau P301S Transgenic Mice Develop Gait and Eye Movement Impairments That Mimic Progressive Supranuclear Palsy

Posted by dbos UCSF

Kavli Affiliate: Alexandra Nelson | Authors: Rose B Creed, Scott C Harris, Sadhana Sridhar, Sascha du Lac, David S Zee, Felice A Dunn, Guy Bouvier and Alexandra B Nelson | Summary: Summary: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with an estimated prevalence of 5-7 people in 100,000. Clinically characterized by impairments in gait, […]


Continue.. Tau P301S Transgenic Mice Develop Gait and Eye Movement Impairments That Mimic Progressive Supranuclear Palsy

Oxytocin receptor controls distinct components of pair bonding and development in prairie voles

Posted by dbos UCSF

Kavli Affiliate: Devanand Manoli and Jeremy Willsey | Authors: Ruchira Sharma, Kristen M. Berendzen, Amanda Everitt, Belinda Wang, Gina Williams, Shuyu Wang, Kara Quine, Rose D. Larios, Kimberly L. P. Long, Nerissa Hoglen, Bibi Alika Sulaman, Marie C. Heath, Michael Sherman, Matthew Kinkel, Angela Cai, Denis Galo, Lizandro Chan Caamal, Nastacia L. Goodwin, Annaliese Beery, […]


Continue.. Oxytocin receptor controls distinct components of pair bonding and development in prairie voles

Encoding manifolds constructed from grating responses organize responses to natural scenes in cortical visual areas

Posted by dbos UCSF

Kavli Affiliate: Michael Stryker | Authors: Luciano Dyballa, Greg D Field, Michael P Stryker and Steven W Zucker | Summary: We have created “encoding manifolds” to reveal the overall responses of a brain area to a variety of stimuli. Encoding manifolds organize response properties globally: each point on an encoding manifold is a neuron, and […]


Continue.. Encoding manifolds constructed from grating responses organize responses to natural scenes in cortical visual areas

Closed-loop modulation of remote hippocampal representations with neurofeedback

Posted by dbos UCSF

Kavli Affiliate: Loren Frank | Authors: Michael E. Coulter, Anna K. Gillespie, Joshua P Chu, Eric L. Denovellis, Trevor T.K. Nguyen, Daniel Liu, Katherine Wadhwani, Biabhav Sharma, Kevin Wang, Xinyi Deng, Uri Eden, Caleb Kemere and Loren M. Frank | Summary: Humans can remember specific events without acting on them and can influence which memories […]


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Type 2 diabetes remodels collateral circulation and promotes leukocyte adhesion following ischemic stroke

Posted by dbos UCSF

Kavli Affiliate: Michael Stryker | Authors: Yoshimichi Sato, Yuandong Li, Yuya Kato, Atsushi Kanoke, Yujiao Jennifer Sun, Yasuo Nishijima, Ruikang K Wang, Michael Stryker, Hidenori Endo and Jialing Liu | Summary: Type 2 diabetes mellitus (T2DM) is associated with impaired leptomeningeal collateral compensation and poor stroke outcome. Neutrophils tethering and rolling on endothelium after stroke […]


Continue.. Type 2 diabetes remodels collateral circulation and promotes leukocyte adhesion following ischemic stroke

Endogenous neuronal DNA double-strand breaks are not sufficient to drive brain aging and neurodegeneration

Posted by dbos UCSF

Kavli Affiliate: Bjoern Schwer | Authors: Sarah Cohen, Laura Cheradame, Karishma Pratt, Sarah Collins, Ashlie Barillas, Annika Carlson, Vijay Ramani, Gaelle Legube, Saul Villeda, Dyche Mullins and Bjoern Schwer | Summary: Loss of genomic information due to the accumulation of somatic DNA damage has been implicated in aging and neurodegeneration. Somatic mutations in human neurons […]


Continue.. Endogenous neuronal DNA double-strand breaks are not sufficient to drive brain aging and neurodegeneration