Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation

Kavli Affiliate: Edward Chang | Authors: Youssef E Sibih, Abraham O Dada, Emily E Cunningham, Niels Olshausen, Jasleen Kaur, Velmurugan Jayabal, Sena Oten, Sanjeev Herr, Cesar N Gonzales, Andy Daniel, Saritha Krishna, Vardhaan S Ambati, Alexander A Aabedi, Gray Umbach, Kanish Mirchia, Poortata Lalwani, Edward F Chang, David R Raleigh, Srikantan Nagarajan, David Brang and […]


Continue.. Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation

Hebb’s Vision: The Structural Underpinnings of Hebbian Assemblie

Kavli Affiliate: Reza Abbasi Asl | Authors: Julian A Wagner-Carena, Sai Kate, Trevor Riordan, Reza Abbasi-Asl, Joe Aman, Adam Amster, Agnes L Bodor, Derrick Brittain, JoAnn Buchanan, Michael A Buice, Daniel J Bumbarger, Forrest Collman, Nuno Macarico da Costa, Daniel J Denman, Saskia EJ de Vries, Emily Joyce, Dan Kapner, Chase W King, Josh D […]


Continue.. Hebb’s Vision: The Structural Underpinnings of Hebbian Assemblie

GABAergic signaling by VIP interneurons gates running-dependent visual recovery in the adult brain

Kavli Affiliate: Michael Stryker | Authors: Anna Lebedeva, Friedrich Kling, Benjamin Rakela, Michael P Stryker and Yujiao Jennifer Sun | Summary: Experience-dependent plasticity in the adult visual cortex is enhanced by locomotion, a process mediated by vasoactive intestinal peptide (VIP)-expressing interneurons. While VIP interneurons are known to signal through both Gamma-aminobutyric acid (GABA) and VIP […]


Continue.. GABAergic signaling by VIP interneurons gates running-dependent visual recovery in the adult brain

Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

Kavli Affiliate: Alexandra Nelson | Authors: Rodrigo M Paz, Michael B Ryan, Pamela F Marcott, Allison E Girasole, Joseph Faryean, Vincent Duong, Sadhana Sridhar and Alexandra B Nelson | Summary: The use of levodopa to manage Parkinson’s disease (PD) symptoms leads to levodopa-induced dyskinesia (LID) and other motor fluctuations, which worsen with disease progression and […]


Continue.. Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

Kavli Affiliate: Hana El-Samad | Authors: Achal Mahajan, Francesca Ratti, Ban Wang, Hana El-Samad, James H. Kaufman and Vishrawas Gopalakrishnan | Summary: Regulation of gene expression is fundamental for proper cellular function, and is constrained by the local chromatin environment of each gene, which varies spatially along the chromosome and is shaped by epigenetic modifications. […]


Continue.. Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

Kavli Affiliate: Robert Edwards | Authors: Mera F. Liccione, Trevor Scobey, Heather M. Froggatt, Camryn Pajon, Boyd L. Yount, Qi Yin, Taylor N. Spence, Emmanuel B. Walter, Kevin O. Saunders, Robert J. Edwards, Ralph S. Baric, Barton F. Haynes, Derek W. Cain, Timothy P. Sheahan and Daniel Wrapp | Summary: HCoV-229E is an endemic Alphacoronavirus […]


Continue.. A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

Kavli Affiliate: Devanand Manoli | Authors: Alexis M Black, Natsumi Komatsu, Jiaxuan Zhao, Scarlet R Taskey, Nicole S Serrano, Ruchira Sharma, Devanand S. Manoli, Markita P Landry and Annaliese Beery | Summary: Friendships, or selective peer relationships, are a vital component of healthy social functioning in humans, while deficits in these relationships are associated with […]


Continue.. Oxytocin receptor absence reduces selectivity in peer relationships and alters neurochemical release dynamics in prairie voles

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

Kavli Affiliate: David Rowitch | Authors: Grant de Jong, Fani Memi, Tannia Gracia, Olga Lazareva, Oliver Gould, Alexander Aivazidis, Manas Dave, Qianqian Zhang, Melanie Jensen, Ahmet Sureyya Rifaioglu, Joao D. Barros-Silva, Sabine Eckert, Di Zhou, Yvette Wood, Elizabeth Tuck, Sezgin Er, Henry Marshall, Kenny Roberts, Andrew L. Trinh, Shreya Rai, Tyler Shaw, Agnes Oszlanczi, Hayden […]


Continue.. A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

A protective role of REM sleep in the pathological basal ganglia-cortical circuit of Parkinson’s disease

Kavli Affiliate: Philip Starr | Authors: Jin-Xiao Zhang, Clay Smyth, Md Fahim Anjum, Yue Leng, Andrew D. Krystal, Philip A. Starr and Simon Little | Summary: Sleep disturbance is involved in the progression of neurodegenerative diseases, but the neurophysiological mechanisms remain unclear in humans. We recorded sleep at home using portable polysomnography for multiple nights […]


Continue.. A protective role of REM sleep in the pathological basal ganglia-cortical circuit of Parkinson’s disease

Working memory by distributed neural oscillators in a simple nervous system

Kavli Affiliate: Noelle L’Etoile and Saul Kato | Authors: Raymond L Dunn, Caitriona Costello, Jackson M Borchardt, Daniel Yutaka Sprague, Grace C Chiu, Julia M Miller, Noelle L’Etoile and Saul Kato | Summary: Working memory allows an animal to gather sensory evidence over time, integrate it with evolving internal needs, and make informed decisions about […]


Continue.. Working memory by distributed neural oscillators in a simple nervous system