Kavli Affiliate: Andrea Hasenstaub | Authors: James Bigelow, Toshiaki Suzuki, Yulang Wu, Ying Hu and Andrea R Hasenstaub | Summary: Recent studies suggest some hippocampal (HC) neurons respond to passively presented sounds in naive subjects, but the specificity and prevalence of these responses remain unclear. We used Neuropixels probes to record unit activity in HC […]
Kavli Affiliate: Kevin Bender | Authors: Elinor Lewis, Jessie Muir, Ling C Li, Julianna Glienke, Sarah Warren Gooding, Kevin Bender, Christina Kim and Jennifer Whistler | Summary: Second generation antipsychotics (SGAs) are widely used clinical tools, yet they often cause negative side effects and take weeks to become effective, leading to poor patient compliance. The […]
Kavli Affiliate: Seth Shipman Eiman Azim | Authors: Abdulkadir Ozkan, Hari K Padmanabhan, Seth Shipman, Eiman Azim, Priyanka Kumar, Cameron Sadegh, Nazli Basak and Jeffrey D Macklis | Summary: Corticospinal neurons (CSN) centrally degenerate in amyotrophic lateral sclerosis (ALS), along with spinal motor neurons, and loss of voluntary motor function in spinal cord injury (SCI) […]
Kavli Affiliate: Arnold R. Kriegstein | Authors: Tanzila Mukhtar, Clara-Vita Siebert, Yuejun Wang, Mark-Phillip Pebworth, Matthew L. White, Tianzhi Wu, Tan Ieng Huang, Guolong Zuo, Jayden Ross, Jennifer Baltazar, Varun Upadhyay, Merut Shankar, Li Zhou, Isabel Lombardi-Coronel, Ishaan Mandala, Manal A. Adam, Shaohui Wang, Qiuli Bi, Marco F.M. Hoekman, Jingjing Li and Arnold Kriegstein | […]
Kavli Affiliate: Robert Edwards | Authors: Aaron J May, Muralikrishna Lella, Jared Lindenberger, Alex Berkman, Ujjwal Kumar, Moumita Dutta, Maggie Barr, Rob Parks, Xiaozhi Lu, Madison Berry, Amanda Newman, Xiao Huang, Kijun Song, Victor Ilevbare, Salam Sammour, Chan Soo Park, Radha Devkota Adhikari, Priyanka Devkota, Katarzyna Janowska, Yanshun Liu, Garrett Scapellato, Taylor N Spence, Katayoun […]
Kavli Affiliate: Vikaas Sohal and Mazen Kheirbek | Authors: Odilia D Lu, Katrina White, Kendall Raymond, Christine Liu, Alexandra S Klein, Nathaniel Green, Sam Vaillancourt, Austin Gallagher, Lena Shindy, Alyssa Li, Ruoxian Li, Mila Zou, Kira Wallquist, Austen B Casey, Lindsay P Cameron, Matthew B Pomrenze, Vikaas Sohal, Mazen A Kheirbek, Andrea M Gomez, Stephan […]
Kavli Affiliate: Kevin Bender | Authors: Hao Wu, Luqun Shen, Jonathan Indajang, Neil K Savalia, Timothy G Johnson, Jiayin Qu, Kevin J Bender and Alex C Kwan | Summary: SCN2A is a high-confidence risk gene for autism spectrum disorder. Loss-of-function mutations in Scn2a reduce dendritic excitability in neocortical pyramidal cells. However, the impact of Scn2a […]
Kavli Affiliate: Kevin Bender | Authors: Joshua D Garcia, Chenyu Wang, Ryan Alexander, Emmie Banks, Timothy Fenton, Jean-Marc DeKeyser, Tatiana V Abramova, Alfred L George, Roy Ben-Shalom, David H Hackos and Kevin J Bender | Summary: Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. These isoforms are differentially localized […]
Kavli Affiliate: Alex Pollen | Authors: Nathan K Schaefer, Bryan J Pavlovic and Alex Aaron Pollen | Summary: Pooled processing, in which cells from multiple sources are cultured or captured together, is an increasingly popular strategy for droplet-based single cell sequencing studies. This design allows efficient scaling of experiments, isolation of cell-intrinsic differences, and mitigation […]
Kavli Affiliate: Robert Edwards | Authors: Laura K Inglis, Michael J Roach, Susanna R Grigson and Robert A. Edwards | Summary: Prophages—viruses that integrate into bacterial genomes—are ubiquitous in the microbial realm. Prophages contribute significantly to horizontal gene transfer, including the potential spread of antimicrobial resistance (AMR) genes, because they can collect host genes. Understanding […]