Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Carlos Johnson-Cruz, Kathleen K.A. Cho and Vikaas S. Sohal | Summary: The mammalian prefrontal cortex encodes variables related to goal-directed behavior, and enables flexibility during environmental changes, making it critical to understand how the dynamic updating vs. stable maintenance of different encodings contribute to behavioral adaptation. We addressed this […]


Continue.. Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

Prefrontal gamma oscillations engage dynamic cell type-specific configurations to support flexible behavior

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Aarron Justin Phensy, Lara Louise Hagopian, Caitriona M. Costello, Simon Haziza, Omkar Ghenand, Yanping Zhang, Mark J. Schnitzer and Vikaas Singh Sohal | Summary: Cognitive dysfunction in conditions such as schizophrenia involves disrupted communication between the prefrontal cortex (PFC) and mediodorsal thalamus (MD). Parvalbumin interneurons (PVI) are known to […]


Continue.. Prefrontal gamma oscillations engage dynamic cell type-specific configurations to support flexible behavior

Protein Structure Informed Bacteriophage Genome Annotation with Phold

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Robert Edwards | Authors: George Bouras, Susanna R Grigson, Milot Mirdita, Michael Heinzinger, Bhavya Papudeshi, Vijini Mallawaarachchi, Renee Green, Rachel Seongeun Kim, Victor Mihalia, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde, Martin Steinegger and Robert A Edwards | Summary: Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for […]


Continue.. Protein Structure Informed Bacteriophage Genome Annotation with Phold

Cell Cycle Arrest of a “Zippering” Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders

Posted by dbos UCSF

Kavli Affiliate: Georgia Panagiotakos | Authors: Tiange Qu, Brandon H Chacon, Louis Faure, Marta Losa, Rocio Hernandez-Martinez, Kelsey Robinson, Aragorn Jones, Steven Lisgo, Maurizio Risolino, Jaiden De Anda, Georgia Panagiotakos, Elizabeth J Leslie-Clarkson, Igor Adameyko and Licia Selleri | Summary: Facial features identify individuals, but the mechanisms shaping the human face remain elusive. Orofacial clefting […]


Continue.. Cell Cycle Arrest of a “Zippering” Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders

Synteny-aware functional annotation of bacteriophage genomes with Phynteny

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Susanna R Grigson, George Bouras, Bhavya Papudeshi, Vijini Mallawaarachchi, Michael J Roach, Przemyslaw Decewicz and Robert A Edwards | Summary: Accurate genome annotation is fundamental to decoding viral diversity and understanding bacteriophage biology; yet, the majority of bacteriophage genes remain functionally uncharacterised. Bacteriophage genomes often exhibit conserved gene order, […]


Continue.. Synteny-aware functional annotation of bacteriophage genomes with Phynteny

Hippocampal input-driven plasticity of prefrontal interneurons reveals a circuit basis for impaired spatial working memory.

Posted by dbos UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Shana E Silverstein, Thomas T Clarity, Meena S Deshpande, Erik Vaughan, Shoshana Novik, Hector E Yarur, Shiliang Zhang, Valerie S Tsai, Rong Ye, Rachel M Mikofsky, Madeline Hsiang, Avery Bauman, Gabriel Loewinger, Francisco Pereira, Marisela Morales, Vikaas S Sohal, Hugo Tejeda, Joshua A Gordon and David A Kupferschmidt | […]


Continue.. Hippocampal input-driven plasticity of prefrontal interneurons reveals a circuit basis for impaired spatial working memory.

Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells in vitro

Posted by dbos UCSF

Kavli Affiliate: Tejal Desai | Authors: Qinghe Zeng, Landon Flemming, Yuanzhou Chen, Thomas Mazumder, Heinz Hammerlindl, Greg M. Allen, Ricardo Almeida, Jasper Z. Williams, Rogelio A. Hernandez-Lopez, Justin Eyquem, Chun Jimmie Ye, Wendell A Lim, Qizhi Tang, Tejal Desai and Xiao Huang | Summary: T cell proliferative capacity and persistence critically determine the therapeutic success […]


Continue.. Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells in vitro

Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Hannelore Longin, George Bouras, Susanna R. Grigson, Robert A. Edwards, Hanne Hendrix, Rob Lavigne and Vera van Noort | Summary: Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, to date, only a […]


Continue.. Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins

Non-visual light modulates behavioral memory and gene expression in C. elegans

Posted by dbos UCSF

Kavli Affiliate: Noelle L’Etoile | Authors: Zhijian Ji, Bingying Wang, Junqiang Liu, Rashmi K. Chandra, Winnie Yang, Yong Long, Michael Egan, Noelle L’Etoile and Dengke K. Ma | Summary: Visible light influences a range of physiological processes, yet how animals respond to it independently of the visual system remains largely unknown. Here, we uncover a […]


Continue.. Non-visual light modulates behavioral memory and gene expression in C. elegans

Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering

Posted by dbos UCSF

Kavli Affiliate: Seth Shipman | Authors: Alejandro Gonzalez-Delgado, Laura Bonillo-Lopez, Milo S Johnson, Nastassia Knoedlseder, Ching-Chung Ko, Yassir Lekbach, Jee-Hwan Oh, Hemaa Selvakumar, Michael C Wold, Zihan Yu, Virginia Aragon, Jeffrey A Gralnick, Marc Guell, Graham Hatfull, Benjamin Keith Keitz, Britt Koskella, Vivek K Mutalik, Jan Peter van Pijkeren and Seth Shipman | Summary: Advanced […]


Continue.. Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering