Pak, a downstream gene of ecdysone signaling, determines left-right polarity in the Drosophila brain through neuronal cell chirality

Kavli Affiliate: Ann-Shyn Chiang | Authors: So Sakamura, Komomo Suyama, Akari Tsujita, Fu-yu Hsu, Atsushi Tamada, Tomoyuki Miyashita, Minoru Saitoe, Ann-Shyn Chiang, Mikiko Inaki and Kenji Matsuno | Summary: Left-right (LR) asymmetry is a conserved characteristic of the brain in various animals and is related to its higher-order functions. The Drosophila brain has an LR […]


Continue.. Pak, a downstream gene of ecdysone signaling, determines left-right polarity in the Drosophila brain through neuronal cell chirality

Inhibitory neurons marked by the connectivity molecule Kirrel3 regulate memory precision

Kavli Affiliate: Mark Ellisman | Authors: Arnulfo B.N. Tunon-Ortiz, Dimitri Trankner, Chandler M. Peterson, Omar Shennib, Fangfei Ye, Jiani Shi, Sarah N. Brockway, Olivia Katherine Raines, Abbey Mahnke, Matthew Grega, Keun-Young Kim, Mark Ellisman, James G. Heys, Moriel Zelikowsky and Megan E Williams | Summary: The homophilic adhesion molecule Kirrel3 drives synapse formation between dentate […]


Continue.. Inhibitory neurons marked by the connectivity molecule Kirrel3 regulate memory precision

Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon

Kavli Affiliate: Robert E. Clark | Authors: Bert van den Berg, Emily Dunbar, Robert Clark, Arnaud Basle, Shenaz Allyjaun, Hector Newman, Julia Hubbard and Syma Khalid | Summary: Bacteriophages are bacterial viruses that provide alternatives to small-molecule drugs to combat infections by antibiotic-resistant bacteria. To infect a bacterial host, a phage needs to bind to […]


Continue.. Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon

Ecological Factors Affecting Prosociality in Marmoset Monkeys

Kavli Affiliate: Cory Miller | Authors: Anand R Mysorekar, Anushka Vispute and Cory Miller | Summary: Prosocial behaviors, such as cooperation and food sharing, are critical for maintaining group cohesion in social species, yet the influence of transient physiological states on these behaviors remains poorly understood. This study investigates how short-term ecological factors impact social […]


Continue.. Ecological Factors Affecting Prosociality in Marmoset Monkeys

Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering

Kavli Affiliate: Marcelo Mattar | Authors: Simone D’Ambrogio, Jan Grohn, Nima Khalighinejad, Marcelo Mattar, Laurence T Hunt and Matthew F Rushworth | Summary: It has been suggested that humans and other animals are driven by a fundamental desire to acquire information about opportunities available in their environments. Not only might such a desire explain pathological […]


Continue.. Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering

Immunoinformatics Approach to Engineer a Multi-Epitope Vaccine Against SdrG in Skin Commensal Staphylococcus epidermidis

Kavli Affiliate: Gabriel Silva | Authors: Shahina Akter, Gabriel Vinícius Rolim Silva, Jonas Ivan Nobre Oliveira, Umberto Laino Fulco, Xianyang Xu and Yu Vincent Fu | Summary: The human skin serves as a dynamic ecosystem for beneficial commensal bacteria such as Staphylococcus epidermidis, which play a crucial role in maintaining skin barrier integrity and modulating […]


Continue.. Immunoinformatics Approach to Engineer a Multi-Epitope Vaccine Against SdrG in Skin Commensal Staphylococcus epidermidis

Spectral disruption of inter-hemispheric resting-state BOLD coherence at vasomotor frequency (~0.1 Hz) links vascular dysfunction to functional connectivity loss in carotid artery stenosis

Kavli Affiliate: David Kleinfeld | Authors: Sangcheon Choi, Gabriel Hoffmann, Sebastian Schneider, Stephan Kaczmarz, David Kleinfeld, Xin Yu, Christian Sorg and Christine Preibisch | Summary: Vasomotor dynamics at the infra-slow frequencies (~0.1 Hz), driven by synchronized oscillation of smooth muscle cells in vessel walls, play an important role in regulating cerebral perfusion and constitute a […]


Continue.. Spectral disruption of inter-hemispheric resting-state BOLD coherence at vasomotor frequency (~0.1 Hz) links vascular dysfunction to functional connectivity loss in carotid artery stenosis

Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

Kavli Affiliate: Sreekanth Chalasani | Authors: Jessica A Haley, Tianyi Chen, Mikio Aoi and Sreekanth H Chalasani | Summary: Decision-making is a ubiquitous component of animal behavior that is often studied in the context of foraging. Foragers make a series of decisions while locating food (food search), choosing between food types (diet or patch choice), […]


Continue.. Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

Development of a Charge-Resistant Embedding Media for High-Performance Serial Block Face Imaging of Cells and Tissues

Kavli Affiliate: Mark Ellisman | Authors: Thomas Deerinck, Steven Peltier and Mark Ellisman | Summary: Serial block-face scanning electron microscopy (SBEM) enables high-resolution 3D imaging of biological specimens but is often limited by specimen charging due to the use of non-conductive epoxy resins. While heavy metal staining and variable-pressure SEM can reduce charging, these methods […]


Continue.. Development of a Charge-Resistant Embedding Media for High-Performance Serial Block Face Imaging of Cells and Tissues

Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

Kavli Affiliate: Mark Ellisman | Authors: Jonathan Choy, Shadi Charara, Kalyani Cauwenberghs, Quintyn McKaughan, Keun-Young Kim, Mark Ellisman and Chih-Ying Su | Summary: Dendritic morphology is a defining characteristic of neuronal subtypes. In Drosophila, heterotypic olfactory receptor neurons (ORNs) expressing different receptors display diverse dendritic morphologies, but whether such diversity exists among homotypic ORNs remains […]


Continue.. Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy