Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

Kavli Affiliate: V. S. Ramachandran | Authors: Nannan Wang, Franklin P. Ockerman, Laura Y. Zhou, Megan L Grove, Taryn Alkis, John Barnard, Russell P. Bowler, Clary B. Clish, Shinhye Chung, Emily Drzymalla, Anne M. Evans, Nora Franceschini, Robert E. Gerszten, Madeline G. Gillman, Scott R. Hutton, Rachel S. Kelly, Charles Kooperberg, Martin G. Larson, Jessica […]


Continue.. Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

A nuclear RNA degradation code for eukaryotic transcriptome surveillance

Kavli Affiliate: Angela Yu | Authors: Lindsey V Soles, Liang Liu, Xudong Zou, Yoseop Yoon, Shuangyu Li, Lusong Tian, Marielle Valdez, Angela Yu, Hong Yin, Wei Li, Fangyuan Ding, Georg Seelig, Lei Li and Yongsheng Shi | Summary: The RNA exosome plays critical roles in eukaryotic RNA degradation, but it remains unclear how the exosome […]


Continue.. A nuclear RNA degradation code for eukaryotic transcriptome surveillance

Population responses to environmental stochasticity are primarily driven by survival-reproduction trade-offs and mediated by aridity

Kavli Affiliate: Gabriel Silva | Authors: Gabriel Silva Santos, Xianyu Yang, Samuel Gascoigne, Aldo Compagnoni, Andre Dias, Shripad D Tuljapurkar, Maja Kajin and Roberto Salguero-Gomez | Summary: Forecasting responses of natural populations to increasingly stochastic environments is a major challenge in Ecology and Conservation Biology. We now know that populations can modulate how their vital […]


Continue.. Population responses to environmental stochasticity are primarily driven by survival-reproduction trade-offs and mediated by aridity

A disinhibitory basal forebrain to cortex projection supports sustained attention

Kavli Affiliate: Edward Callaway | Authors: Shu-Jing Li, Balazs Hangya, Unmukt Gupta, Kyle B. Fischer, James Fitzhugh Sturgill, Edward M. Callaway and Adam Kepe | Summary: Sustained attention, as an essential cognitive faculty governing selective sensory processing, exhibits remarkable temporal fluctuations. However, the underlying neural circuits and computational mechanisms driving moment-to-moment attention fluctuations remain elusive. […]


Continue.. A disinhibitory basal forebrain to cortex projection supports sustained attention

A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in a glutamatergic spine reveals dynamics of kinase activation in the first several seconds after a complex synaptic stimulus.

Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B Kennedy | Summary: Long-term potentiation (LTP) is a biochemical process in excitatory glutamatergic synapses in the Central Nervous System (CNS). It is initiated by a bout of synaptic activation that is strong enough to contribute to […]


Continue.. A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in a glutamatergic spine reveals dynamics of kinase activation in the first several seconds after a complex synaptic stimulus.

Complementary Organization of Driver and Modulator Cortico-Thalamo-Cortical Circuits

Kavli Affiliate: Edward Callaway | Authors: Rachel M. Cassidy, Angel V. Macias, Willian N. Lagos, Chiamaka Ugorji and Edward M. Callaway | Summary: Corticocortical (CC) projections in the visual system facilitate the hierarchical processing of sensory information. In addition to direct CC connections, indirect cortico-thalamo-cortical (CTC) pathways through the pulvinar nucleus of the thalamus can […]


Continue.. Complementary Organization of Driver and Modulator Cortico-Thalamo-Cortical Circuits

Control of innate olfactory valence by segregated cortical amygdala circuits

Kavli Affiliate: Kay Tye | Authors: James R Howe, Chung-Lung Chan, Donghyung Lee, Marlon Blanquart, Haylie Romero, Abigail N Zadina, Mackenzie E Lemieux, Paula A Desplats, Kay M Tye and Cory M Root | Summary: Animals perform innate behaviors that are stereotyped responses to specific evolutionarily relevant stimuli in the absence of prior learning or […]


Continue.. Control of innate olfactory valence by segregated cortical amygdala circuits

Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits

Kavli Affiliate: Nicola Allen | Authors: James Deng, Lara Labarta-Bajo, Ashley N Brandebura, Samuel B Kahn, Antonio F M Pinto, Jolene K Diedrich and Nicola J Allen | Summary: Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder with manifestations spanning molecular, neuroanatomical, and behavioral changes. Astrocytes contribute to FXS pathogenesis and show hundreds of […]


Continue.. Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits

Low-dimensional olfactory signatures of fruit ripening and fermentation

Kavli Affiliate: Tatyana Sharpee | Authors: Yuansheng Zhou, Thomas F O’Connell, Majid Ghaninia, Brian Smith, Elizabeth J Hong and Tatyana O Sharpee | Summary: Odors provide an important communication channel between plants and animals. Fruits, vital nutrient sources for animals, emit a complex array of monomolecular volatiles. Animals can use the structure of these mixtures […]


Continue.. Low-dimensional olfactory signatures of fruit ripening and fermentation

Posterior parietal cortex maps progress along routes sharing the same meta-structure

Kavli Affiliate: Douglas Nitz | Authors: Alexander B Johnson and Douglas A Nitz | Summary: Neurons of posterior parietal cortex were recorded as rats performed a working memory task within a network of intersecting paths. The specific routes utilized in task performance provided opportunity to contrast responses of posterior parietal cortex sub-populations to linear and […]


Continue.. Posterior parietal cortex maps progress along routes sharing the same meta-structure