HLA-E and NKG2A Mediate Resistance to M. bovis BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer

Kavli Affiliate: Li Zhao | Authors: Daniel Ranti, Haocheng Yu, Yuanshuo Wang, Christine Bieber, Trine Strandgaard, Berengere Salome, Sean Houghton, Junbum Kim, Hiranmayi Ravichandran, Iyinyeoluwa Okulate, Elliot Merritt, Sunjoo Bang, Alexandros Demetriou, Zhao Li, Sia Viborg Lindskrog, Dan Fu Ruan, Jorge Daza, Richa Rai, Everardo Hegewisch-Solloa, Emily Mace, Ruben Fernandez-Rodriguez, Sudeh Izadmehr, Glenn Doherty, Adam […]


Continue.. HLA-E and NKG2A Mediate Resistance to M. bovis BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer

Estrus-Tracking Cortical Neurons Integrate Social cues and Reproductive states to Adaptively Control Sexually Dimorphic Sociosexual Behaviors

Kavli Affiliate: Nathaniel Heintz | Authors: Yuping Wang, Xinli Song, Xiangmao Chen, Ying Zhou, Jihao Ma, Fang Zhang, Liqiang Wei, Guoxu Qi, Nakul Yadav, Benjie Miao, Yiming Yan, Guohua Yuan, Da Mi, Priyamvada Rajasethupathy, Ines Ibanez-Tallon, Xiaoxuan Jia, Nathaniel Heintz and Kun Li | Summary: Female sociosexual behaviors, essential for survival and reproduction, are adaptively […]


Continue.. Estrus-Tracking Cortical Neurons Integrate Social cues and Reproductive states to Adaptively Control Sexually Dimorphic Sociosexual Behaviors

Brain Charts for the Rhesus Macaque Lifespan

Kavli Affiliate: Winrich Freiwald | Authors: Samuel Alldritt, Julian S.B. Ramirez, Reinder Vos de Wael, Richard Bethlehem, Jakob Seidlitz, Zexi Wang, Karl-Heinz Nenning, Nathalia B. Esper, Jonathan Smallwood, Alexandre R. Franco, Kyoungseob Byeon, Aaron Alexander-Bloch, Adam Messinger, Aihua Chen, Alexander Thiele, Alison R. Weiss, Amir Shmuel, Andrew Fox, Anita Tusche, Ansgar M. Brambrink, Arnaud Falchier, […]


Continue.. Brain Charts for the Rhesus Macaque Lifespan

A Hybrid Type I and II Polyketide Synthases Yields Distinct Aromatic Polyketides

Kavli Affiliate: Li Zhao | Authors: Li Ya Zhao, Jing Shi, Zhao Yang Xu, Jia Lin Sun, Zhang Yuan Yan, Zhi Wu Tong, Ren Xiang Tan, Rui Hua Jiao and Hui Ming Ge | Summary: Bacterial aromatic polyketides are compounds with multiple aromatic rings synthesized by bacterial type II polyketide synthases (PKSs), some of which […]


Continue.. A Hybrid Type I and II Polyketide Synthases Yields Distinct Aromatic Polyketides

Polyunsaturated fatty acid-derived lipid mediator networks characterize COVID-19 severity and risk for critical illness

Kavli Affiliate: Martin Lindquist | Authors: Maria Papadaki, Eleftherios Pavlos, Marc Dubourdeau, Vincent Bailif, Kamal Badirou, Ioanna-Evdokia Galani, Dimitris Papelis, Natalia Kamperi, Vasiliki Triantafyllia, Lena Siouti, Maria Salagianni, Maria Manioudaki, Nikolaos Paschalidis, Giannis Vatsellas, Evangelia Koukaki, Vasiliki Rapti, Dimitris Thanos, Nikoletta Rovina, Garyfallia Poulakou, Aurelie Cobat, Jean-Laurent Casanova, Constantin Tamvakopoulos and Evangelos Andreakos | Summary: […]


Continue.. Polyunsaturated fatty acid-derived lipid mediator networks characterize COVID-19 severity and risk for critical illness

Using artificial intelligence to document the hidden RNA virosphere

Kavli Affiliate: Li Zhao | Authors: Xin Hou, Yong He, Pan Fang, Shi-Qiang Mei, Zan Xu, Wei-Chen Wu, Jun-Hua Tian, Shun Zhang, Zhen-Yu Zeng, Qin-Yu Gou, Gen-Yang Xin, Shi-Jia Le, Yin-Yue Xia, Yu-Lan Zhou, Feng-Ming Hui, Yuan-Fei Pan, John-Sebastian Eden, Zhao-Hui Yang, Chong Han, Yue-Long Shu, Deyin Guo, Jun Li, Edward C Holmes, Zhao-Rong Li […]


Continue.. Using artificial intelligence to document the hidden RNA virosphere

Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activation

Kavli Affiliate: Robert B. Darnell | Authors: Ruth A Singer, Veronika Rajchin, Kwanghoon Park, Nathaniel Heintz and Robert B Darnell | Summary: Neuronal diversity and function are intricately linked to the dynamic regulation of RNA metabolism, including splicing, localization, and translation. Electrophysiologic studies of synaptic plasticity, models for learning and memory, are disrupted in Fragile […]


Continue.. Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activation

An enhanced Eco1 retron editor enables precision genome engineering in human cells from a single-copy integrated lentivirus

Kavli Affiliate: Charles M. Rice | Authors: Matthew A Cattle, Lauren C Aguado, Samantha Sze, Dylan Yueyang Wang, Thales Papagiannakopoulos, Susan Smith, Charles M Rice, William Matthew Schneider and John T Poirier | Summary: Retrons are a retroelement class found in diverse prokaryotes that can be adapted to augment CRISPR-Cas9 genome engineering technology to efficiently […]


Continue.. An enhanced Eco1 retron editor enables precision genome engineering in human cells from a single-copy integrated lentivirus

A microglia clonal inflammatory disorder in Alzheimer’s Disease

Kavli Affiliate: Damon Clark | Authors: Parisa A Vaziri, Samuel D McDougle and Damon A Clark | Summary: To discern speech or appreciate music, the human auditory system detects how pitch increases or decreases over time. However, the algorithms used to detect changes in pitch, or pitch motion, are incompletely understood. Here, using psychophysics, computational […]


Continue.. A microglia clonal inflammatory disorder in Alzheimer’s Disease

Complete sequencing of ape genomes

Kavli Affiliate: Erich Jarvis | Authors: DongAhn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A. Logsdon, Steven J. Solar, Dmitry Antipov, Brandon D. Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M. Storer, Jiadong Lin, Abigail N. Sequeira, Riley J. Mangan, Glenn Hickey, Graciela Monfort Anez, Parithi Balachandran, Anton Bankevich, Christine R. […]


Continue.. Complete sequencing of ape genomes