Kavli Affiliate: Roderick MacKinnon | Authors: Maria Elizabeth Falzone and Roderick MacKinnon | Summary: PLCβ enzymes cleave PIP2 producing IP3 and DAG. PIP2 modulates the function of many ion channels, while IP3 and DAG regulate intracellular Ca2+ levels and protein phosphorylation by protein kinase C, respectively. PLCb enzymes are under the control of GPCR signaling […]
Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Jonathan S Marvin, Alexandros C Kokotos, Mukesh Kumar, Camila Pulido, Ariana N Tkachuk, Jocelyn Shuxin Yao, Timothy A Brown and Timothy A Ryan | Summary: We developed a significantly improved genetically encoded quantitative adenosine triphosphate (ATP) sensor to provide real-time dynamics of ATP levels in subcellular […]
Kavli Affiliate: Michael Higley, Alipasha Vaziri, Kristina Nielsen | Authors: Che-Hang Yu, Yiyi Yu, Liam M. Adsit, Jeremy T. Chang, Jad Barchini, Andrew H. Moberly, Hadas Benisty, Jinkyung Kim, Brent K Young, Kathleen Heng, Deano M. Farinella, Austin Leikvoll, Rishaab Pavan, Rachel Vistein, Brandon R. Nanfito, David G. C. Hildebrand, Santiago Otero-Coronel, Alipasha Vaziri, Jeffery […]
Kavli Affiliate: Winrich Freiwald | Authors: Amirhossein Farzmahdi, Wilbert Zarco, Winrich Freiwald, Nikolaus Kriegeskorte and Tal Golan | Summary: Primates can recognize objects despite 3D geometric variations such as in-depth rotations. The computational mechanisms that give rise to such invariances are yet to be fully understood. A curious case of partial invariance occurs in the […]
Kavli Affiliate: Erich Jarvis | Authors: Delphine Lariviere, Linelle Abueg, Nadolina Brajuka, Cristobal Gallardo-Alba, Bjorn Gruning, Byung June Ko, Alex Ostrovsky, Marc Palmada-Flores, Brandon D. Pickett, Keon Rabbani, Jennifer R. Balacco, Mark Chaisson, Haoyu Cheng, Joanna Collins, Alexandra Denisova, Olivier Fedrigo, Guido Roberto Gallo, Alice Maria Giani, Grenville MacDonald Gooder, Nivesh Jain, Cassidy Johnson, Heebal […]
Kavli Affiliate: Li Zhao | Authors: Samuel Khodursky, Eric B Zheng, Nicolas Svetec, Sylvia M Durkin, Sigi Benjamin, Alice Gadau, Xia Wu and Li Zhao | Summary: The evolution of regulatory regions in the genome plays a critical role in shaping the diversity of life. While this process is primarily sequence-dependent, the enormous complexity of […]
Kavli Affiliate: Li Zhao | Authors: Junhui Peng and Li Zhao | Summary: Although previously thought to be unlikely, recent studies have shown that de novo gene origination from previously non-genic sequences is a common mechanism for gene innovation in many species and taxa. These young genes provide a unique set of candidates to study […]
Kavli Affiliate: Eric D. Siggia | Authors: Teresa Krammer, Hannah Taylor Stuart, Elena Gromberg, Keisuke Ishihara, Manuela Melchionda, Jingkui Wang, Elena Costantini, Stefanie Lehr, Dillon Cislo, Laura Arbanas, Alexandra Hoermann, Ralph Alexander Neumueller, Nicola Elvassore, Eric Siggia, James Briscoe, Anna Kicheva and Elly Margaret Tanaka | Summary: Organoids can undergo pattern formation by spontaneously forming […]
Kavli Affiliate: Michael W. Young | Authors: Georgia F Papadaki, Claire H Woodward, Michael C Young, Trenton J Winters, George M Burslem and Nikolaos G Sgourakis | Summary: Human Tapasin (hTapasin) is the main chaperone of MHC-I molecules, enabling peptide loading and antigen repertoire optimization across HLA allotypes. However, it is restricted to the endoplasmic […]
Kavli Affiliate: Ali H. Brivanlou | Authors: Tiago L Laundos, Shu Li, Eric Cheang, Riccardo De Santis, Francesco M Piccolo and Ali H. Brivanlou | Summary: Huntington’s disease (HD) remains an incurable and fatal neurodegenerative disease long after CAG-expansion mutation in the huntingtin gene (HTT) was identified as the cause. The underlying pathological mechanism, whether […]