Neuroscience – Page 89 – Kavli Institute Pre-Print Publications

SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling

Posted by klaurent March 27, 2023April 10, 2023UCSD / Salk

Kavli Affiliate: Jose Ricardo Suarez | Authors: Blanca Dies, Ana de Lucas-Rius, Laura Mendoza, Transito Garcia, Raul Fernandez, Jose Manuel Suarez, Fatima Milhano, Fernando Corrales, Natalia Redondo, Federica Pedrucci, Sara Zaldivar, Maria Angeles Jimenez, Maria Montoya and Juan Jose Garrido | Summary: SARS-CoV-2, the cause of the COVID19 pandemic, possesses eleven accessory proteins encoded in […]

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Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons

Posted by klaurent March 26, 2023April 5, 2023Columbia

Kavli Affiliate: Franck Polleux | Authors: Daniel M Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Emiliano Zamponi, Natalie J Park, Victoria L Hewitt, David Zhang, Kevin C Gonzalez, Erik Bloss, Franck Polleux and Tommy L Lewis, Jr. | Summary: Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake, and therefore have instructive roles […]

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SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling

Posted by klaurent March 26, 2023April 5, 2023UCSF

Kavli Affiliate: Yuh Nung Jan, Lily Jan | Authors: Sami Tapio Tuomivaara, Chin Fen Teo, Yuh Nung Jan, Lily Y Jan and Arun Paul Wiita | Summary: To facilitate our understanding of the often rapid and nuanced dynamics of extracellularly exposed proteomes during signaling events, it is important to devise robust workflows affording fast time […]

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Leveraging vision to understand curiosity

Posted by klaurent March 23, 2023March 27, 2023Columbia

Kavli Affiliate: Jacqueline Gottlieb | Authors: Michael Cohanpour, Mariam Aly and Jacqueline Gottlieb | Summary: Humans are immensely curious and motivated to reduce uncertainty. Inspired by studies of sensory uncertainty, we hypothesized that visual areas provide multivariate representations of uncertainty, which are read out by higher-order areas that encode confidence and, ultimately, translated into curiosity. […]

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A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements

Posted by klaurent March 21, 2023April 5, 2023UCSD / Salk

Kavli Affiliate: Samuel Pfaff | Authors: Marito Hayashi, Miriam Gullo, Gokhan Senturk, Stefania Di Costanzo, Shinji C. Nagasaki, Ryoichiro Kageyama, Itaru Imayoshi, Martyn Goulding, Samuel L. Pfaff and Graziana Gatto | Summary: Innate and goal-directed movements require a high-degree of trunk and appendicular muscle coordination to preserve body stability while ensuring the correct execution of […]

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Mesoscale volumetric light field (MesoLF) imaging of neuroactivity across cortical areas at 18 Hz

Posted by klaurent March 21, 2023April 5, 2023Rockefeller

Kavli Affiliate: Alipasha Vaziri | Authors: Tobias Nöbauer, Yuanlong Zhang, Hyewon Kim and Alipasha Vaziri | Summary: Various implementations of mesoscopes provide optical access for calcium imaging across multi-millimeter fields-of-view (FOV) in the mammalian brain. However, capturing the activity of the neuronal population within such FOVs near-simultaneously and in a volumetric fashion has remained challenging […]

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Comparative landscape of genetic dependencies in human and chimpanzee stem cells

Posted by klaurent March 20, 2023March 27, 2023UCSF

Kavli Affiliate: Alex Pollen | Authors: Richard She, Tyler Fair, Nathan K. Schaefer, Reuben A. Saunders, Bryan J Pavlovic, Jonathan S. Weissman and Alex A. Pollen | Summary: Comparative studies of great apes provide a window into our evolutionary past, but the extent and identity of cellular differences that emerged during hominin evolution remain largely […]

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Defective callosal termination underlies the long-term behavioral deficits in NMDA receptor antibody encephalitis mouse model

Posted by klaurent March 19, 2023March 27, 2023UCSF

Kavli Affiliate: Samuel Pleasure | Authors: Jing Zhou, Ariele Greenfield, Rita Loudermilk, Christopher Bartley, Baouyen Tran, Chao Zhao, Hong Wang, Michael Wilson and Samuel Pleasure | Summary: NMDA receptor antibody encephalitis (NMDAR-AE) is characterized by cerebrospinal fluid (CSF)-resident anti-NMDA receptor autoantibodies that cause a wide range of neurological manifestations. Although many symptoms are responsive to […]

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Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

Posted by klaurent March 19, 2023March 27, 2023Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Ariane J Brown, John Won, Raphael Wolfisberg, Ulrik Fanhoe, Nicholas Catanzaro, Ande West, Fernando Moreira, Mariana Nogeuira Batista, Martin T. Ferris, Colton Linnertz, Sarah R Leist, Cameron Nguyen, Gabriella De la Cruz, Bentley Midkiff, Yongjuan Xia, Stephanie A Montgomery, Eva Billerbeck, Jens Bukh, Troels Scheel, Charles M Rice […]

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Dual credit assignment processes underlie dopamine signals in a complex spatial environment

Posted by klaurent March 19, 2023March 27, 2023UCSF

Kavli Affiliate: Joshua Berke, Loren Frank | Authors: Timothy Amos Krausz, Alison E. Comrie, Loren M. Frank, Nathaniel Douglass Daw and Joshua D. Berke | Summary: Dopamine in the nucleus accumbens helps motivate behavior based on expectations of future reward (“values”). These values need to be updated by experience: after receiving reward, the choices that […]

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