A spatially resolved single cell genomic atlas of the adult human breast

Kavli Affiliate: Robert Edwards | Authors: Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei, Min Hu, Anna Casasent, Aatish Thennavan, Jianzhuo Li, Tuan Tran, Ken Chen, Benedikt Nilges, Nachiket Kashikar, Oliver Braubach, Bassem Cheikh, Nadya Nikulina, Hui Chen, Mediate Teshome, Brian Menegaz, Huma […]


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The Promise and Pitfalls of Prophages

Kavli Affiliate: Robert Edwards | Authors: Jody C McKerral, Bhavya Nalagampalli Papudeshi, Laura K Inglis, Michael J Roach, Przemyslaw Decewicz, Katelyn McNair, Antoni Luque, Elizabeth A Dinsdale and Robert A Edwards | Summary: Phages dominate every ecosystem on the planet. While virulent phages sculpt the microbiome by killing their bacterial hosts, temperate phages provide unique […]


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Contigs directed gene annotation (ConDiGA) for accurate protein sequence database construction in metaproteomics

Kavli Affiliate: Xiaoqing Qin Wang | Authors: Enhui Wu, Vijini Mallawaarachchi, Jinzhi Zhao, Yi Yang, Hebin Liu, Xiaoqing Wang, Chengpin Shen, Yu Lin and Liang Qiao | Summary: Microbiota are closely associated to human health and disease. Metaproteomics can provide a direct means to identify microbial proteins in microbiota for compositional and functional characterization. However, […]


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Electrophysiological correlates of attention in the locus coeruleus – anterior cingulate cortex circuit during the rodent continuous performance test

Kavli Affiliate: Keri Martinowich | Authors: Henry L Hallock, Suhaas Adiraju, Jorge Miranda-Barrientos, Jessica M McInerney, Seyun Oh, Adrienne C DeBrosse, Ye Li, Gregory Carr and Keri Martinowich | Summary: Sustained attention, the ability to focus on an activity or stimulus over time, is significantly impaired in many psychiatric disorders, and there remains a major […]


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Influence of Alzheimer’s disease related neuropathology on local microenvironment gene expression in the human inferior temporal cortex

Kavli Affiliate: Keri Martinowich | Authors: Sang Ho Kwon, Sowmya Parthiban, Madhavi Tippani, Heena R Divecha, Nicholas J Eagles, Jashandeep S Lobana, Stephen R Williams, Michelle Mark, Rahul A Bharadwaj, Joel E Kleinman, Thomas M Hyde, Stephanie C Page, Stephanie C Hicks, Keri Martinowich, Kristen R Maynard and Leonardo Collado-Torres | Summary: Neuropathological lesions in […]


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Regression models for partially localized fMRI connectivity analyses

Kavli Affiliate: Martin Lindquist, Brian Caffo | Authors: Bonnie B. Smith, Yi Zhao, Martin A. Lindquist and Brian Caffo | Summary: Brain functional connectivity analysis of resting-state functional magnetic resonance imaging (fMRI) data is typically performed in a standardized template space assuming consistency of connections across subjects. This can come in the form of one-edge-at-a-time […]


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Artificial intelligence redefines RNA virus discovery

Kavli Affiliate: Li Zhao | Authors: Xin Hou, Yong He, Pan Fang, Shi-Qiang Mei, Zan Xu, Wei-Chen Wu, Jun-Hua Tian, Shun Zhang, Zhen-Yu Zeng, Qin-Yu Gou, Gen-Yang Xin, Shi-Jia Le, Yin-Yue Xia, Yu-Lan Zhou, Feng-Ming Hui, Yuan-Fei Pan, John-Sebastian Eden, Zhao-Hui Yang, Chong Han, Yue-Long Shu, Deyin Guo, Jun Li, Edward C Holmes, Zhao-Rong Li […]


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Using rare genetic mutations to revisit structural brain asymmetry

Kavli Affiliate: David Linden | Authors: Jakub Kopal, Kuldeep Kumar, Kimia Shafighi, Karin Saltoun, Claudia Modenato, Clara A. Moreau, Guillaume Huguet, Martineau Jean-Louis, Charles-Olivier Martin, Zohra Saci, Nadine Younis, Elise Douard, Khadije Jizi, Alexis Beauchamp-Chatel, Leila Kushan, Ana I. Silva, Marianne B. M. van den Bree, David E. J. Linden, Michael J. Owen, Jeremy Hall, […]


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Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-typespecific vulnerabilities in human brain organoids

Kavli Affiliate: Jin Kang | Authors: ChangHui Pak, Rebecca Sebastian, Kang Jin, Narciso Pavon, Ruby Bansal, Andrew Potter, Yoonjae Song, Juliana Babu, Rafael Gabriel, Yubing Sun and Bruce J Aronow | Summary: De novo mutations and copy number deletions in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). It is unclear how NRXN1 deletions […]


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Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

Kavli Affiliate: Daniel Mucida, Elaine Fuchs | Authors: Sandra Nakandakari-Higa, Maria Cecilia Campos Canesso, Sarah Walker, Aleksey Chudnovskiy, Johanne T Jacobsen, S. Martina Parigi, Karol Fiedorczuk, Elaine Fuchs, Angelina M Bilate, Giulia Pasqual, Daniel Mucida, Yuri Pritykin and Gabriel D Victora | Summary: Cellular interactions are essential for tissue organization and functionality. In particular, immune […]


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