Neuroscience – Page 85 – Kavli Institute Pre-Print Publications

Performant web-based interactive visualization tool for spatially-resolved transcriptomics experiments

Posted by klaurent January 29, 2023March 7, 2023Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Chaichontat Sriworarat, Annie B. Nguyen, Nicholas J. Eagles, Leonardo Collado-Torres, Keri Martinowich, Kristen R. Maynard and Stephanie C. Hicks | Summary: High-resolution and multiplexed imaging techniques are giving us an increasingly detailed observation of a biological system. However, sharing, exploring, and customizing the visualization of large multidimensional images can […]

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Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

Posted by klaurent January 28, 2023February 7, 2023Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Alicia M Braxton, Ashley L Kiemen, Mia P Grahn, Andre Forjaz, Jaanvi Mahesh Babu, Lily Zheng, Liping Jiang, Haixia Cheng, Qianqian Song, Rebecca Reichel, Sarah Graham, Alexander I Damanakis, Catherine G Fischer, Stephanie Mou, Cameron Metz, Julie Granger, Xiao-Ding Liu, Niklas Bachmann, Cristina Almagro-Perez, Ann Chenyu Jiang, Jeonghyun Yoo, […]

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Contribution of protein conformational heterogeneity to NMR lineshapes at cryogenic temperatures

Posted by klaurent January 25, 2023February 7, 2023Columbia

Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Keith Fritzsching, Rivkah Rogawski, Yunyao Xu and Ann E McDermott | Summary: While low temperature NMR holds great promise for the analysis of unstable samples and for sensitizing NMR detection, spectral broadening in frozen protein samples is a common experimental challenge. One hypothesis explaining the additional linewidth […]

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Predicted and Experimental NMR Chemical Shifts at Variable Temperatures: The Effect of Protein Conformational Dynamics

Posted by klaurent January 25, 2023February 7, 2023Columbia

Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Lichirui Zhang, Richard Friesner and Ann E McDermott | Summary: NMR chemical shifts provide a sensitive probe of protein structure and dynamics. Prediction of shifts, and therefore interpretation of shifts, particularly for the frequently measured amidic 15N sites, remains a tall challenge. We demonstrate that protein 15N […]

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Zinc Alters the Supramolecular Organization of Nucleic Acid Complexes with Full-Length TIA1

Posted by klaurent January 25, 2023February 7, 2023Columbia

Kavli Affiliate: Ann McDermott | Authors: Yizhuo Yang, Keith Fritzsching, Sasha He and Ann E McDermott | Summary: T-Cell Intracellular Antigen-1 (TIA1) is a 43 kDa multi-domain RNA-binding protein involved in stress granule formation during eukaryotic stress response, and has been implicated in neurodegenerative diseases including Welander distal myopathy and amyotrophic lateral sclerosis. TIA1 contains […]

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Common rules underlying optogenetic and behavioral modulation of responses in multi-cell-type V1 circuits

Posted by klaurent January 22, 2023February 7, 2023Columbia

Kavli Affiliate: Kenneth Miller | Authors: Agostina Palmigiano, Francesco Fumarola, Daniel P. Mossing, Nataliya Kraynyukova, Hillel Adesnik and Kenneth Miller | Summary: The visual cortex receives non-sensory inputs containing behavioral and brain state information. Here we propose a parallel between optogenetic and behavioral modulations of activity and characterize their impact on cell-type-specific V1 processing under […]

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Hierarchical Deviant Processing in Auditory Cortex of Awake Mice

Posted by klaurent January 20, 2023April 5, 2023Hopkins

Kavli Affiliate: Patrick Kanold | Authors: Dan Luo, Ji Liu, Ryszard Auksztulewicz, Tony Ka Wing Yip, Patrick O. Kanold and Jan W. Schnupp | Summary: Detecting patterns, and noticing unexpected pattern changes, in the environment is a vital aspect of sensory processing. Adaptation and prediction error responses are two components of neural processing related to […]

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Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes

Posted by klaurent January 20, 2023February 7, 2023UCSF

Kavli Affiliate: Saul Kato | Authors: Morgan M Stanton, Sara Modan, Patrick M Taylor, Harsh N Hariani, Jordan Sorokin, Brian G Rash, Sneha B Rao, Alejandro Lopez-Tobon, Luigi Enriquez, Brenda Dang, Dorah Owango, Shannon O’Neill, Carlos Castrillo, Justin Nicola, Kathy Ye, Robert M Blattner, Federico Gonzalez, Dexter Antonio, Pavan Ramkumar, Andy Lash, Douglas Flanzer, Sophia […]

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Hippocampal area CA2 controls seizure dynamics, interictal EEG abnormalities and social comorbidity in mouse models of temporal lobe epilepsy

Posted by klaurent January 19, 2023February 7, 2023Columbia

Kavli Affiliate: Steven Siegelbaum | Authors: Christos Panagiotis Lisgaras, Azahara Oliva, Sam Mckenzie, John LaFrancois, Steven A. Siegelbaum and Helen E. Scharman | Summary: Temporal lobe epilepsy (TLE) is characterized by spontaneous recurrent seizures, abnormal activity between seizures, and impaired behavior. CA2 pyramidal neurons (PNs) are potentially important because inhibiting them with a chemogenetic approach […]

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EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

Posted by klaurent January 18, 2023January 30, 2023UCSD / Salk

Kavli Affiliate: Jose Suarez Lopez | Authors: Sukanya Chakraborty, Aaqib M. Bhat, Insha Mushtaq, Haitao Luan, Achyuth Kalluchi, Sameer Mirza, Matthew D. Storck, Nagendra Chaturvedi, Jose Antonio Lopez-Guerreo, Antonio Llombart-Bosch, Isidro Machado, Jane L. Meza, Gargi Ghosal, Donald W. Coulter, Jordan M. Rowley, Vimla Band, Bhopal C. Mohapatra and Hamid Band | Summary: We previously […]

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