Kavli Affiliate: Nicola Allen | Authors: Alexandra P Bosworth, Minerva Contreras, Sammy Weiser Novak, Laura Sancho, Isabel H Salas, Uri Manor and Nicola J Allen | Summary: The maturation and stabilization of appropriate synaptic connections is a vital step in the development of neuronal circuits, however the molecular signals underlying these processes are not fully […]
Kavli Affiliate: Franck Polleux | Authors: Baptiste Libe-Philippot, Ryohei Iwata, Aleksandra J Recupero, Keimpe Wierda, Martyna Ditkowska, Vaiva Gaspariunaite, Ben Vermaercke, Eugenie Peze-Heidsieck, Daan Remans, Cecile Charrier, Franck Polleux and Pierre Vanderhaeghen | Summary: Human-specific (HS) genes are potential drivers of brain evolution, but their impact on human neuron development and disease remains unclear. Here […]
Kavli Affiliate: Michael Miller, Joshua Vogelstein | Authors: Thomas Athey, Matthew Wright, Marija Pavlovic, Vikram Chandrashekhar, Karl Deisseroth, Michael Miller and Joshua Vogelstein | Summary: Whole-brain fluorescence images require several stages of computational processing to fully reveal the neuron morphology and connectivity information they contain. However, these computational tools are rarely part of an integrated […]
Kavli Affiliate: Edward Chang | Authors: Lingyun Zhao, Alexander B. Silva, Garret L. Kurteff and Edward F. Chang | Summary: Natural speech is full of starts and stops. Here, we studied the neural mechanisms that underlie the inhibitory control of speech, specifically the ability to stop speaking on demand. We recorded direct cortical activity while […]
Kavli Affiliate: Terry Jernigan, Timothy Brown | Authors: Ethan Roy, Adam Richie-Halford, John Kruper, Manjari Narayan, David Bloom, Pierre Nedelec, Leo P. Sugrue, Andreas Rauschecker, Timothy T. Brown, Terry L. Jernigan, Bruce D. McCandliss, Ariel Rokem and Jason D. Yeatman | Summary: Cross-sectional studies have linked differences in white matter tissue properties to reading skills. […]
Kavli Affiliate: Darcy Peterka | Authors: Georgia Bastos, Jacob T Holmes, Jordan M Ross, Anna M Rader, Connor G Gallimore, Darcy S Peterka and Jordan P Hamm | Summary: Visual processing is strongly influenced by context. Stimuli that deviate from contextual regularities elicit augmented responses in primary visual cortex (V1). These heightened responses, known as […]
Kavli Affiliate: Stephen Strittmatter | Authors: Austin Stoner, Li Fu, LaShae Nicholson, Chao Zheng, Takuya Toyonaga, Joshua Spurrier, Will Laird, Zhengxin Cai and Stephen M. Strittmatter | Summary: Background Cellular prion protein (PrPC) is a high-affinity cell-surface receptor for Amyloid-β oligomers (Aßo). In certain overexpression models of Alzheimer’s Disease (AD), pharmacology and genetics demonstrate its […]
Kavli Affiliate: Richard Axel | Authors: Ryan Lorig-Roach, Melissa Meredith, Jean Monlong, Miten Jain, Hugh Olsen, Brandy McNulty, David Porubsky, Tessa G. Montague, Julian Lucas, Chris Condon, Jordan Eizenga, Sissel Juul, Sean McKenzie, Sara Simmonds, Jimin Park, Mobin Asri, Sergey Koren, Evan Eichler, Richard Axel, Bruce Martin, Paolo Carnevali, Karen Miga and Benedict Paten | […]
Kavli Affiliate: Patrick Kanold | Authors: Didhiti Mukherjee, Binghan Xue, Chih-Ting Chen, Minzi Chang, Joseph P-Y. Kao and Patrick O. Kanold | Summary: Sensory perturbation in one modality results in adaptive reorganization of neural pathways within the spared modalities, a phenomenon known as “crossmodal plasticity”, which has been examined during or after the classic ‘critical […]
Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Jiwen Li, Marlesa I. Godoy, Alice J. Zhang, Graciel Diamante, In Sook Ahn, Arantxa Cebrian-Silla, Arturo Alvarez-Buylla, Xia Yang, Bennett G. Novitch and Ye Zhang | Summary: Embryonic neural stem cells (NSCs, i.e., radial glia) in the ventricular-subventricular zone (V-SVZ) generate the majority of neurons and glia in the […]