Statistical power and false positive rates for interdependent outcomes are strongly influenced by test type: Implications for behavioral neuroscience

Posted by klaurent Rockefeller

Kavli Affiliate: Michael W. Young | Authors: Michelle Frankot, Peyton M Mueller, Michael E Young and Cole Vonder Haar | Summary: Statistical errors in preclinical science are a barrier to reproducibility and translation. For instance, linear models (e.g., ANOVA, linear regression) may be misapplied to data that violate assumptions. In behavioral neuroscience and psychopharmacology, linear […]


Continue.. Statistical power and false positive rates for interdependent outcomes are strongly influenced by test type: Implications for behavioral neuroscience

Adrenomedullin promotes interneuron migration in a dual human model for hypoxic interneuronopathy of prematurity.

Posted by klaurent UCSF

Kavli Affiliate: Jeremy Willsey | Authors: Wojciech M Michno, Alyssa Puno, Li Li, Amanda Everitt, Kate McCluskey, Fikri Birey, Saw Htun, Dhriti Nagar, Yuqin Dai, Emily Gurwitz, Jeremy Willsey and Anca M Pasca | Summary: Extremely preterm born individuals at < 28 postconceptional weeks (PCW) are at high risk for encephalopathy of prematurity and life-long […]


Continue.. Adrenomedullin promotes interneuron migration in a dual human model for hypoxic interneuronopathy of prematurity.

FEMA: Fast and efficient mixed-effects algorithm for large sample whole-brain imaging data

Posted by klaurent UCSD / Salk

Kavli Affiliate: Wesley Thompson, Anders Dale | Authors: Pravesh Parekh, Chun Chieh Fan, Oleksandr Frei, Clare E Palmer, Diana M. Smith, Carolina Makowski, John Iverson, Diliana Pecheva, Dominic Holland, Robert Loughnan, Pierre Nedelec, Wesley K Thompson, Donald J. Hagler, Jr., Ole A. Andreassen, Terry L Jernigan, Thomas Nichols and Anders M. Dale | Summary: The […]


Continue.. FEMA: Fast and efficient mixed-effects algorithm for large sample whole-brain imaging data

Simple decoding of behavior from a complicated neural manifold

Posted by klaurent Columbia

Kavli Affiliate: Mark Churchland | Authors: Sean M. Perkins, John P. Cunningham, Qi Wang and Mark M. Churchland | Summary: Decoders for brain-computer interfaces (BCIs) assume constraints on neural activity, chosen to reflect scientific beliefs while yielding tractable computations. We document how low tangling — a typical property of motor-cortex neural trajectories — yields unusual […]


Continue.. Simple decoding of behavior from a complicated neural manifold

Visually evoked neuronal ensembles reactivate during sleep

Posted by klaurent Columbia

Kavli Affiliate: Rafael Yuste | Authors: Justin Lines and Rafael Yuste | Summary: Neuronal ensembles, defined as groups of coactive neurons, dominate cortical activity and are causally related to perceptual states and behavior. Interestingly, ensembles occur spontaneously in the absence of sensory stimulation. To better understand the function of ensembles in spontaneous activity, we explored […]


Continue.. Visually evoked neuronal ensembles reactivate during sleep

TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis

Posted by klaurent UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Sumin Kim, Sebastien Phan, Thomas R Shaw, Mark H Ellisman, Sarah L Veatch, Sami J Barmada, Samuel S Pappas and William T Dauer | Summary: Nuclear pore complexes (NPCs) regulate information transfer between the nucleus and cytoplasm. NPC defects are linked to several neurological diseases, but the processes governing […]


Continue.. TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis

3D structural human interactome reveals proteome-wide perturbations by disease mutations

Posted by klaurent Hopkins

Kavli Affiliate: Jin Kang | Authors: Dapeng Xiong, Junfei Zhao, Yunguang Qiu, Yadi Zhou, Dongjin Lee, Shobhita Gupta, Weiqiang Lu, Siqi Liang, Jin Joo Kang, Charis Eng, Joseph Loscalzo, Feixiong Cheng and Haiyuan Yu | Summary: Human genome sequencing studies have identified numerous loci associated with complex diseases. However, translating human genetic and genomic findings […]


Continue.. 3D structural human interactome reveals proteome-wide perturbations by disease mutations

Layer 5a Corticostriatal Projection Neurons are Selectively Vulnerable in Huntington’s Disease

Posted by klaurent Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Alison R Weiss, William Liguore, Thomas Carroll, David A Davis, Jodi McBride and Nathaniel Heintz | Summary: The properties of the cell types that are most vulnerable in the Huntington’s disease (HD) cortex, the nature of somatic CAG expansion […]


Continue.. Layer 5a Corticostriatal Projection Neurons are Selectively Vulnerable in Huntington’s Disease

Cell Type Specific CAG Repeat Expansion and Toxicity of Mutant Huntingtin in Human Striatal and Cerebellar Cell Types

Posted by klaurent Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Kert Mätlik, Matthew Baffuto, Laura Kus, David A Davis, Matthew R Paul, Thomas S Carroll and Nathaniel Heintz | Summary: Tissue-specific somatic expansion of the mutant Huntingtin (mHTT) CAG tract and regional degeneration of the brain are key features of Huntington’s disease (HD). However, the relationships between somatic CAG […]


Continue.. Cell Type Specific CAG Repeat Expansion and Toxicity of Mutant Huntingtin in Human Striatal and Cerebellar Cell Types

Insights for disease modeling from single cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Posted by klaurent Hopkins

Kavli Affiliate: Loyal Goff | Authors: Debamitra Das, Shreyash Sonthalia, Genevieve G Stein-O’Brien, Marah Wahbeh, Kyra Feuer, Loyal Goff, Carlo Colantuoni, Vasiliki Machairaki and Dimitrios Avramopoulos | Summary: Trans-differentiation of human induced pluripotent stem cells into neurons via Ngn2-induction (hiPSC-N) has become an efficient system to quickly generate neurons for disease modeling and in vitro […]


Continue.. Insights for disease modeling from single cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture