Mesoscale volumetric light field (MesoLF) imaging of neuroactivity across cortical areas at 18 Hz

Posted by klaurent Rockefeller

Kavli Affiliate: Alipasha Vaziri | Authors: Tobias Nöbauer, Yuanlong Zhang, Hyewon Kim and Alipasha Vaziri | Summary: Various implementations of mesoscopes provide optical access for calcium imaging across multi-millimeter fields-of-view (FOV) in the mammalian brain. However, capturing the activity of the neuronal population within such FOVs near-simultaneously and in a volumetric fashion has remained challenging […]


Continue.. Mesoscale volumetric light field (MesoLF) imaging of neuroactivity across cortical areas at 18 Hz

Comparative landscape of genetic dependencies in human and chimpanzee stem cells

Posted by klaurent UCSF

Kavli Affiliate: Alex Pollen | Authors: Richard She, Tyler Fair, Nathan K. Schaefer, Reuben A. Saunders, Bryan J Pavlovic, Jonathan S. Weissman and Alex A. Pollen | Summary: Comparative studies of great apes provide a window into our evolutionary past, but the extent and identity of cellular differences that emerged during hominin evolution remain largely […]


Continue.. Comparative landscape of genetic dependencies in human and chimpanzee stem cells

Defective callosal termination underlies the long-term behavioral deficits in NMDA receptor antibody encephalitis mouse model

Posted by klaurent UCSF

Kavli Affiliate: Samuel Pleasure | Authors: Jing Zhou, Ariele Greenfield, Rita Loudermilk, Christopher Bartley, Baouyen Tran, Chao Zhao, Hong Wang, Michael Wilson and Samuel Pleasure | Summary: NMDA receptor antibody encephalitis (NMDAR-AE) is characterized by cerebrospinal fluid (CSF)-resident anti-NMDA receptor autoantibodies that cause a wide range of neurological manifestations. Although many symptoms are responsive to […]


Continue.. Defective callosal termination underlies the long-term behavioral deficits in NMDA receptor antibody encephalitis mouse model

Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

Posted by klaurent Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Ariane J Brown, John Won, Raphael Wolfisberg, Ulrik Fanhoe, Nicholas Catanzaro, Ande West, Fernando Moreira, Mariana Nogeuira Batista, Martin T. Ferris, Colton Linnertz, Sarah R Leist, Cameron Nguyen, Gabriella De la Cruz, Bentley Midkiff, Yongjuan Xia, Stephanie A Montgomery, Eva Billerbeck, Jens Bukh, Troels Scheel, Charles M Rice […]


Continue.. Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

Dual credit assignment processes underlie dopamine signals in a complex spatial environment

Posted by klaurent UCSF

Kavli Affiliate: Joshua Berke, Loren Frank | Authors: Timothy Amos Krausz, Alison E. Comrie, Loren M. Frank, Nathaniel Douglass Daw and Joshua D. Berke | Summary: Dopamine in the nucleus accumbens helps motivate behavior based on expectations of future reward (“values”). These values need to be updated by experience: after receiving reward, the choices that […]


Continue.. Dual credit assignment processes underlie dopamine signals in a complex spatial environment

Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

Posted by klaurent Rockefeller

Kavli Affiliate: Michael W. Young | Authors: Yi Sun, Michael C Young, Claire H Woodward, Julia N Danon, Hau V Truong, Sagar Gupta, Trenton J Winters, George Burslem and Nikolaos G Sgourakis | Summary: The polymorphic nature and intrinsic instability of class I major histocompatibility complex (MHC-I) and MHC-like molecules loaded with suboptimal peptides, metabolites, […]


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Hypothalamic thyroid hormone deficiency underlies reversible anorexia in a mammalian hibernator

Posted by klaurent Yale

Kavli Affiliate: Elena Gracheva | Authors: Sarah M Mohr, Rafael Dai Pra, Maryann P Platt, Viktor V Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K Merriman, Tamas L Horvath, Sviatoslav N Bagriantsev and Elena O Gracheva | Summary: Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal […]


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SpatialScope: A unified approach for integrating spatial and single-cell transcriptomics data using deep generative models

Posted by klaurent UCSD / Salk

Kavli Affiliate: Angela Wu | Authors: Xiaomeng Wan, Jiashun Xiao, Sindy Sing Ting Tam, Mingxuan Cai, Ryohichi Sugimura, Yang Wang, Xiang Wan, Zhixiang Lin, Angela Wu and Can Yang | Summary: The rapid emergence of spatial transcriptomics (ST) technologies are revolutionizing our under-standing of tissue spatial architecture and their biology. Current ST technologies based on […]


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Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data

Posted by klaurent Yale

Kavli Affiliate: Flora Vaccarino | Authors: Rujia Dai, Tianyao Chu, Ming Zhang, Xuan Wang, Alexandre Jourdon, Feinan Wu, Jessica Mariani, Flora M. Vaccarino, Donghoon Lee, John F Fullard, Gabriel E Hoffman, Panos Roussos, Yue Wang, Xusheng Wang, Dalilla Pinto, Sidney Wang, Chunling Zhang, Chao Chen and CHUNYU LIU | Summary: Sample-wise deconvolution methods have been […]


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A brief real-time fNIRS-informed neurofeedback training of the prefrontal cortex changes brain activity and connectivity during subsequent working memory challenge

Posted by klaurent Hopkins

Kavli Affiliate: David Linden | Authors: Xi Yang, Yixu Zeng, Guojuan Jiao, Xiyang Gan, David Linden, Dennis Hernaus, Chaoze Zhu, Keshuang Li, Dezhong Yao, Shuxia Yao, Yihan Jiang and Benjamin Becker | Summary: Working memory (WM) represents a building-block of higher cognitive functions and a wide range of mental disorders are associated with WM impairments. […]


Continue.. A brief real-time fNIRS-informed neurofeedback training of the prefrontal cortex changes brain activity and connectivity during subsequent working memory challenge