Exploration biases how forelimb reaches to a spatial target are learned

Kavli Affiliate: Costa, Rui | Authors: Alice C Mosberger, Leslie J Sibener, Tiffany X Chen, Helio FM Rodrigues, Richard Hormigo, James N Ingram, Vivek R Athalye, Tanya Tabachnik, Daniel M Wolpert, James M Murray and Rui M Costa | Summary: The brain can learn to generate actions, such as reaching to a target, using different […]


Continue.. Exploration biases how forelimb reaches to a spatial target are learned

Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson’s Disease: Model Based Predictions and Validation in Three Human Subjects

Kavli Affiliate: Philip Starr | Authors: James J. Sermon, Maria Olaru, Juan Anso, Stephanie Cernera, Simon Little, Maria Shcherbakova, Rafal Bogacz, Philip A. Starr, Timothy Denison and Benoit Duchet | Summary: Objectives The exact mechanisms of deep brain stimulation (DBS) are still an active area of investigation, in spite of its clinical successes. This is […]


Continue.. Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson’s Disease: Model Based Predictions and Validation in Three Human Subjects

Prophage rates in the human microbiome vary by body site and host health.

Kavli Affiliate: Robert Edwards | Authors: Laura K Inglis, Michael J. Roach and Robert A Edwards | Summary: Phages integrated into a bacterial genome–called prophages–continuously monitor the health of the host bacteria to determine when to escape the genome, protect their host from other phage infections, and may provide genes that promote bacterial growth. Prophages […]


Continue.. Prophage rates in the human microbiome vary by body site and host health.

Large-scale brain-wide neural recording in nonhuman primates

Kavli Affiliate: Mark Churchland, Michael Shadlen | Authors: Eric M. Trautmann, Janis K. Hesse, Gabriel M. Stine, Ruobing Xia, Shude Zhu, Daniel J. O’Shea, Bill Karsh, Jennifer Colonell, Frank F. Lanfranchi, Saurabh Vyas, Andrew Zimnik, Natalie A. Steinmann, Daniel A. Wagenaar, Alexandru Andrei, Carolina Mora Lopez, John O’Callaghan, Jan Putzeys, Bogdan C. Raducanu, Marleen Welkenhuysen, […]


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Automatic Discovery of Cognitive Strategies with Tiny Recurrent Neural Networks

Kavli Affiliate: Marcelo Mattar | Authors: Li Ji-An, Marcus K Benna and Marcelo G Mattar | Summary: Normative frameworks such as Bayesian inference and reward-based learning are useful tools for explaining the fundamental principles of adaptive behavior. However, their ability to describe realistic animal behavior is limited by the often small number of parameters that […]


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Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal

Kavli Affiliate: Michael Beer | Authors: Bess P. Rosen, Qing V. Li, Hyunwoo Cho, Dingyu Liu, Dapeng Yang, Sarah Graff, Jielin Yan, Renhe Luo, Nipun Verma, Jeyaram R. Damodaran, Michael A. Beer, Simone Sidoli and Danwei Huangfu | Summary: Pluripotent stem cells are defined by both the ability to unlimitedly self-renew and differentiate to any […]


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Age-related increases in fibroblasts-secreted IGFBP2 increase melanoma cell invasion and lipid synthesis.

Kavli Affiliate: Denis Wirtz | Authors: Gretchen M Alicea, Marie E Portuallo, Payal Patel, Mitchell E Fane, Alexis Carey, David W. Speicher, Andrew Kossenkov, Vito W Rebecca III, Denis Wirtz and Ashani T Weeraratna | Summary: Aged melanoma patients (>65 years old) have more aggressive disease relative to young patients (5-fold levels of insulin-like growth […]


Continue.. Age-related increases in fibroblasts-secreted IGFBP2 increase melanoma cell invasion and lipid synthesis.

Diverging maternal and infant cord antibody functions from SARS-CoV-2 infection and vaccination in pregnancy

Kavli Affiliate: Jin Kang | Authors: Emily H. Adhikari, Pei Lu, Ye Jin Kang, Ann R. McDonald, Jessica E. Pruszynski, Timothy A Bates, Savannah K. McBride, Mila Trank-Greene, Fikadu G Tafesse and Lenette L. Lu | Summary: Immunization in pregnancy is a critical tool that can be leveraged to protect the infant with an immature […]


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Brain-wide Correspondence Between Neuronal Epigenomics and Long-Distance Projections

Kavli Affiliate: Edward Callaway | Authors: Jingtian Zhou, Zhuzhu Zhang, May Wu, Hanqing Liu, Yan Pang, Anna Bartlett, Angeline C. Rivkin, Will N. Lagos, Elora Williams, Cheng-Ta Lee, Paula Assakura Miyazaki, Andrew I. Aldridge, Qiurui Zeng, J.L. Angelo Salinda, Naomi Claffey, Michelle Liem, Conor Fitzpatrick, Lara Boggeman, Zizhen Yao, Kimberly A. Smith, Bosiljka Tasic, Jordan […]


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