A systematic search for RNA structural switches across the human transcriptome

Kavli Affiliate: Yifan Cheng | Authors: Matvei Khoroshkin, Daniel Asarnow, Albertas Navickas, Aidan Winters, Johnny Yu, Simon K. Zhou, Shaopu Zhou, Christina Palka, Lisa Fish, K. Mark Ansel, Yifan Cheng, Luke A. Gilbert and Hani Goodarzi | Summary: RNA structural switches are key regulators of gene expression in bacteria, yet their characterization in Metazoa remains […]


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Modulation of dependencies by brain states in a laminar cortical circuit

Kavli Affiliate: Anirvan Nandy | Authors: Anirban Das, Alec G. Sheffield, Anirvan S. Nandy and Monika P. Jadi | Summary: Adaptive information processing, comprised of local computations and their efficient routing, is crucial for flexible brain function. Spatial attention is a quintessential example of this adaptive process. It is critical for recognizing and interacting with […]


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Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions

Kavli Affiliate: Michael Beer | Authors: Renhe Luo, Jielin Yan, Jin Woo Oh, Wang Xi, Dustin Shigaki, Wilfred Wong, Hyunwoo Cho, Dylan Murphy, Ronald Cutler, Bess P. Rosen, Julian Pulecio, Dapeng Yang, Rachel Glenn, Tingxu Chen, Qing V. Li, Thomas Vierbuchen, Simone Sidoli, Effie Apostolou, Danwei Huangfu and Michael A. Beer | Summary: Comprehensive enhancer […]


Continue.. Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions

Cortico-Striatal Beta-Oscillations as a Marker of Learned Reward Value

Kavli Affiliate: Dhakshin Ramanathan, Jyoti Mishra | Authors: M.F. Koloski, S. Hulyalkar, T. Tang, X. Wu, L. Fakhraei, S.A. Barnes, J. Mishra, D.S. Ramanathan | Summary: Abstract Single neuron correlates of reward value have been observed in brain regions along the cortico-striatal pathway including ventral striatum, orbital, and medial prefrontal cortex. Brain imaging studies in […]


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Novel crAssphage isolates exhibit conserved gene order and purifying selection of the host specificity protein

Kavli Affiliate: Robert Edwards | Authors: Bhavya Papudeshi, Alejandro A Vega, Cole Souza, Sarah K Giles, Vijini Mallawaarachchi, Michael J. Roach, Michelle An, Nicole Jacobson, Katelyn McNair, Maria Fernanda Mora, Karina Pastrana, Christopjer Leigh, Clarice Cram, Will S Plewa, Susanna R Grigson, George Bouras, Przemyslaw Decewicz, Antoni Luque, Lindsay Droit, Scott Allyn Handley, Anca Segall, […]


Continue.. Novel crAssphage isolates exhibit conserved gene order and purifying selection of the host specificity protein

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

Kavli Affiliate: Robert Edwards | Authors: Kevin Saunders, James Counts, Victoria Stalls, Robert Edwards, Kartik Manne, Xiaozhi Lu, Bhishem Thakur, Katayoun Mansouri, Yue Chen, Rob Parks, Maggie Barr, Laura Sutherland, Joena Bal, Nicholas Havill, Haiyan Chen, Emily Machiele, Nolan Jamieson, Bhavna Hora, Megan Kopp, Katarzyna Janowska, Kara Anasti, Chuancang Jiang, Sravani Venkatayogi, Amanda Eaton, Rory […]


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Heritability estimation of cognitive phenotypes in the ABCD Study using mixed models

Kavli Affiliate: Wesley Thompson, Anders Dale, Terry Jernigan | Authors: Diana M. Smith, Robert John Loughnan, Naomi P. Friedman, Pravesh Parekh, Oleksandr Frei, Wesley K. Thompson, Ole Andreassen, Michael Neale, Terry L. Jernigan and Anders Dale | Summary: Twin and family studies have historically aimed to partition phenotypic variance into components corresponding to additive genetic […]


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Robust Online Multiband Drift Estimation in Electrophysiology Data

Kavli Affiliate: Liam Paninski | Authors: Charlie Windolf, Angelique C Paulk, Yoav Kfir, Eric Trautmann, Samuel Garcia, Domokos Meszéna, William Muñoz, Irene Caprara, Mohsen Jamali, Julien C Boussard, Ziv M Williams, Sydney S Cash, Liam Paninski and Erdem Varol | Summary: High-density electrophysiology probes have opened new possibilities for systems neuroscience in human and non-human […]


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Astrocyte glypican 5 regulates synapse maturation and stabilization

Kavli Affiliate: Nicola Allen | Authors: Alexandra P Bosworth, Minerva Contreras, Sammy Weiser Novak, Laura Sancho, Isabel H Salas, Uri Manor and Nicola J Allen | Summary: The maturation and stabilization of appropriate synaptic connections is a vital step in the development of neuronal circuits, however the molecular signals underlying these processes are not fully […]


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Human synaptic neoteny requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition

Kavli Affiliate: Franck Polleux | Authors: Baptiste Libe-Philippot, Ryohei Iwata, Aleksandra J Recupero, Keimpe Wierda, Martyna Ditkowska, Vaiva Gaspariunaite, Ben Vermaercke, Eugenie Peze-Heidsieck, Daan Remans, Cecile Charrier, Franck Polleux and Pierre Vanderhaeghen | Summary: Human-specific (HS) genes are potential drivers of brain evolution, but their impact on human neuron development and disease remains unclear. Here […]


Continue.. Human synaptic neoteny requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition