Structured memory representations develop at multiple time scales in hippocampal-cortical networks

Posted by klaurent UCSD / Salk

Kavli Affiliate: Anastasia Kiyonaga | Authors: Arielle Tambini, Jacob Miller, Luke Ehlert, Anastasia Kiyonaga and Mark D’Esposito | Summary: Influential views of systems memory consolidation posit that the hippocampus rapidly forms representations of specific events, while neocortical networks extract regularities across events, forming the basis of schemas and semantic knowledge. Neocortical extraction of schematic memory […]


Continue.. Structured memory representations develop at multiple time scales in hippocampal-cortical networks

CellCover Defines Conserved Cell Types and Temporal Progression in scRNA-seq Data across Mammalian Neocortical Development

Posted by klaurent Hopkins

Kavli Affiliate: Donald Geman, Laurent Younes | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Accurate identification of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. Such analyses […]


Continue.. CellCover Defines Conserved Cell Types and Temporal Progression in scRNA-seq Data across Mammalian Neocortical Development

3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle

Posted by klaurent Yale

Kavli Affiliate: Elena Gracheva | Authors: Yury A Nikolaev, Luke H Ziolkowski, Song Pang, Wei-Ping Li, Viktor V Feketa, C Shan Xu, Elena O Gracheva and Sviatoslav N Bagriantsev | Summary: Mechanosensory corpuscles detect transient touch and vibratory signals in the skin of vertebrates, enabling navigation, foraging, and precise manipulation of objects1. The corpuscle core […]


Continue.. 3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle

Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons

Posted by klaurent Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Svitlana V Bach, Allison J Bauman, Darya Hosein, Jennifer J Tuscher, Lara Ianov, Kelsey M Greathouse, Benjamin W Henderson, Jeremy H. Herskowitz, Keri Martinowich and Jeremy J Day | Summary: Brain-derived neurotrophic factor (Bdnf) plays a critical role in brain development, dendritic growth, synaptic plasticity, as well as learning […]


Continue.. Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons

Predictive Sequence Learning in the Hippocampal Formation

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Yusi Chen, Huanqiu Zhang and Terrence J Sejnowski | Summary: We linked the temporal precision of neural encoding to the implementation of cognitive functions through predictive sequence learning. The hippocampus of rodents receives sequences of sensory inputs from the cortex during exploration and then encodes the sequences with millisecond […]


Continue.. Predictive Sequence Learning in the Hippocampal Formation

Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China

Posted by klaurent Rockefeller

Kavli Affiliate: Li Zhao | Authors: Michelle Baker, Xibin Zhang, Alexandre Maciel-Guerra, Kubra Babaarslan, Yinping Dong, Wei Wang, Yujie Hu, David Renney, Longhai Liu, Hui Li, Zhiqin Tong, Nicole Pearcy, Meimei Zhang, Yingzhi Geng, Li Zhao, Zhihui Hao, Junshi Chen, Zixin Peng, Fengqin Li and Tania Dottorini | Summary: Sharing among different pathogens and commensals […]


Continue.. Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China

Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development

Posted by klaurent Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Anoushka Joglekar, Wen Hu, Bei Zhang, Oleksandr Narykov, Mark Diekhans, Jennifer Balacco, Lishomwa Ndhlovu, Teresa A Milner, Olivier Fedrigo, Erich D Jarvis, Gloria M Sheynkman, Dmitry Korkin, Margaret Elizabeth Ross and Hagen U Tilgner | Summary: RNA isoforms influence cell identity and function. Until recently, technological limitations prevented a […]


Continue.. Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development

Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling, and cloud-native open-source tools

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski, Nathaniel Sawtell | Authors: Dan Biderman, Matthew R Whiteway, Cole Hurwitz, Nicholas R Greenspan, Robert S Lee, Ankit Vishnubhotla, Michael Schartner, Julia M Huntenburg, Anup Khanal, Guido T Meijer, Jean-Paul Noel, Alejandro Pan-Vazquez, Karolina Z Socha, Anne E Urai, The International Brain Laboratory, Richard Warren, Dillon Noone, Federico Pedraja, John Cunningham, […]


Continue.. Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling, and cloud-native open-source tools

Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

Posted by klaurent Hopkins

Kavli Affiliate: Loyal Goff | Authors: Subhash Kulkarni, Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Laren S Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna Leser, Mithra Kumar, Shriya Bakhshi, Matthew J Anderson, Mark Lewandoski, Elizabeth Vincent, Loyal Goff and Pankaj Jay Pasricha | Summary: The enteric nervous system (ENS), a collection […]


Continue.. Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

High-throughput colocalization pipeline quantifies efficacy of mitochondrial targeting signals across different protein types

Posted by klaurent UCSF

Kavli Affiliate: Seth Shipman | Authors: Sierra K Lear, Jose A Nunez and Seth L Shipman | Summary: Efficient metabolic engineering and the development of mitochondrial therapeutics often rely upon the specific and strong import of foreign proteins into mitochondria. Fusing a protein to a mitochondria-bound signal peptide is a common method to localize proteins […]


Continue.. High-throughput colocalization pipeline quantifies efficacy of mitochondrial targeting signals across different protein types