Cell specificity of adeno-associated virus (AAV) serotypes in human cortical organoids

Kavli Affiliate: Robert Edwards | Authors: Morgan M Stanton, Harsh N Hariani, Jordan Sorokin, Patrick M Taylor, Sara Modan, Brian G Rash, Sneha B Rao, Luigi Enriquez, Daphne Quang, Pei-Ken Hsu, Justin Paek, Dorah Owango, Carlos Castrillo, Justin Nicola, Pavan Ramkumar, Andy Lash, Douglas Flanzer, Kevan Shah, Saul Kato and Gaia Skibinski | Summary: Human-derived […]


Continue.. Cell specificity of adeno-associated virus (AAV) serotypes in human cortical organoids

Programmed ribosomal frameshifts, and how to find them

Kavli Affiliate: Robert Edwards | Authors: Katelyn McNair, Peter Salamon, Robert A. Edwards and Anca M. Segall | Summary: One of the stranger phenomena that can occur during gene translation is where, as a ribosome reads along the mRNA, various cellular and molecular properties contribute to stalling the ribosome on a slippery sequence, shifting the […]


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A rapid and bidirectional reporter of neural activity reveals neural correlates of social behaviors in Drosophila

Kavli Affiliate: Richard Axel | Authors: Moise Bonheur, Kurtis J. Swartz, Melissa G. Metcalf, Anna Zhukovskaya, Avirut Mehta, Kristin E. Connors, Julia G. Barasch, Xinke Wen, Andrew R. Jamieson, Kelsey C. Martin, Richard Axel and Daisuke Hattori | Summary: Neural activity is modulated over different timescales encompassing sub-seconds to days reflecting changes in external environment, […]


Continue.. A rapid and bidirectional reporter of neural activity reveals neural correlates of social behaviors in Drosophila

The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

Kavli Affiliate: Angela Yu | Authors: Liang Liu, Angela M Yu, Xiuye Wang, Lindsey V. Soles, Yiling Chen, Yoseop Yoon, Kristianna S.K. Sarkan, Marielle Cárdenas Valdez, Johannes Linder, Ivan Marazzi, Zhaoxia Yu, Feng Qiao, Wei Li, Georg Seelig and Yongsheng Shi | Summary: JTE-607 is a small molecule compound with anti-inflammation and anti-cancer activities. Upon […]


Continue.. The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

Perirhinal Cortex Learns A Predictive Map of The Task Environment

Kavli Affiliate: Stefano Fusi | Authors: David G. Lee, Caroline A. McLachlan, Ramon Nogueira, Osung Kwon, Alanna E. Carey, Garrett House, Gavin D. Lagani, Danielle LaMay, Stefano Fusi and Jerry L. Chen | Summary: Goal-directed tasks involve acquiring an internal model, known as a predictive map, of relevant stimuli and associated outcomes to guide behavior. […]


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Do perineuronal nets stabilize the engram of a synaptic circuit?

Kavli Affiliate: Mark Ellisman | Authors: Varda Lev-Ram, Sakina Palida, Thomas J Deerinck, Eric A Bushong, Brandon H Toyoma, Alex Perez, Daniel B McClatchy, Denise R Prichard, Jeffrey N Savas, Mark H Ellisman, John Robert Yates III and Roger Y Tsien | Summary: Perineuronal nets (PNN), a specialized form of ECM, surround numerous neurons in […]


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Comparative single cell epigenomic analysis of gene regulatory programs in the rodent and primate neocortex

Kavli Affiliate: Michael Miller, Edward Callaway | Authors: Nathan R Zemke, Ethan J Armand, Wenliang Wang, Seoyeon Lee, Jingtian Zhou, Yang Eric Li, Hanqing Liu, Wei Tian, Joseph R Nery, Rosa G Castanon, Anna Bartlett, Julia K Osteen, Daofeng Li, Xiaoyu Zhuo, Vincent Xu, Michael Miller, Fenna M Krienen, Qiangge Zhang, Naz Taskin, Jonathan Ting, […]


Continue.. Comparative single cell epigenomic analysis of gene regulatory programs in the rodent and primate neocortex

A brain atlas of the camouflaging dwarf cuttlefish, Sepia bandensis

Kavli Affiliate: Richard Axel | Authors: Tessa G. Montague, Isabelle J. Rieth, Sabrina Gjerswold-Selleck, Daniella Garcia-Rosales, Sukanya Aneja, Dana Elkis, Nanyan Zhu, Sabrina Kentis, Frederick A. Rubino, Adriana Nemes, Katherine Wang, Luke A. Hammond, Roselis Emiliano, Rebecca A. Ober, Jia Guo and Richard Axel | Summary: The coleoid cephalopods (cuttlefish, octopus, and squid) are a […]


Continue.. A brain atlas of the camouflaging dwarf cuttlefish, Sepia bandensis

Frugivory and seed predation of fishtail palm (Caryota mitis Lour.) on the remote oceanic island of Narcondam, India

Kavli Affiliate: V. S. Ramachandran | Authors: Abhishek Gopal, Sartaj Ghuman, Navendu Page, Vivek Ramachandran and Rohit Naniwadekar | Summary: Oceanic islands, due to their evolutionary history and isolation, hold a disproportionately high proportion of endemic species. However, their evolutionary history also makes them vulnerable to extinctions, with most known extinctions occurring on islands. Plant-animal […]


Continue.. Frugivory and seed predation of fishtail palm (Caryota mitis Lour.) on the remote oceanic island of Narcondam, India

Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure

Kavli Affiliate: Mark Ellisman | Authors: Tylor R Lewis, Sebastien Phan, Carson M Castillo, Keun-Young Kim, Kelsey Coppenrath, William Thomas, Ying Hao, Nikolai P Skiba, Marko E Horb, Mark H Ellisman and Vadim Y Arshavsky | Summary: The first steps of vision take place within a stack of tightly packed disc-shaped membranes, or “discs”, located […]


Continue.. Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure