Kavli Affiliate: Marcelo Mattar | Authors: Li Ji-An, Marcus K Benna and Marcelo G Mattar | Summary: Normative frameworks such as Bayesian inference and reward-based learning are useful tools for explaining the fundamental principles of adaptive behavior. However, their ability to describe realistic animal behavior is limited by the often small number of parameters that […]
Kavli Affiliate: Michael Beer | Authors: Bess P. Rosen, Qing V. Li, Hyunwoo Cho, Dingyu Liu, Dapeng Yang, Sarah Graff, Jielin Yan, Renhe Luo, Nipun Verma, Jeyaram R. Damodaran, Michael A. Beer, Simone Sidoli and Danwei Huangfu | Summary: Pluripotent stem cells are defined by both the ability to unlimitedly self-renew and differentiate to any […]
Kavli Affiliate: Denis Wirtz | Authors: Gretchen M Alicea, Marie E Portuallo, Payal Patel, Mitchell E Fane, Alexis Carey, David W. Speicher, Andrew Kossenkov, Vito W Rebecca III, Denis Wirtz and Ashani T Weeraratna | Summary: Aged melanoma patients (>65 years old) have more aggressive disease relative to young patients (5-fold levels of insulin-like growth […]
Kavli Affiliate: Jin Kang | Authors: Emily H. Adhikari, Pei Lu, Ye Jin Kang, Ann R. McDonald, Jessica E. Pruszynski, Timothy A Bates, Savannah K. McBride, Mila Trank-Greene, Fikadu G Tafesse and Lenette L. Lu | Summary: Immunization in pregnancy is a critical tool that can be leveraged to protect the infant with an immature […]
Kavli Affiliate: Edward Callaway | Authors: Jingtian Zhou, Zhuzhu Zhang, May Wu, Hanqing Liu, Yan Pang, Anna Bartlett, Angeline C. Rivkin, Will N. Lagos, Elora Williams, Cheng-Ta Lee, Paula Assakura Miyazaki, Andrew I. Aldridge, Qiurui Zeng, J.L. Angelo Salinda, Naomi Claffey, Michelle Liem, Conor Fitzpatrick, Lara Boggeman, Zizhen Yao, Kimberly A. Smith, Bosiljka Tasic, Jordan […]
Kavli Affiliate: Michael W. Young | Authors: Michelle Frankot, Peyton M Mueller, Michael E Young and Cole Vonder Haar | Summary: Statistical errors in preclinical science are a barrier to reproducibility and translation. For instance, linear models (e.g., ANOVA, linear regression) may be misapplied to data that violate assumptions. In behavioral neuroscience and psychopharmacology, linear […]
Kavli Affiliate: Jeremy Willsey | Authors: Wojciech M Michno, Alyssa Puno, Li Li, Amanda Everitt, Kate McCluskey, Fikri Birey, Saw Htun, Dhriti Nagar, Yuqin Dai, Emily Gurwitz, Jeremy Willsey and Anca M Pasca | Summary: Extremely preterm born individuals at < 28 postconceptional weeks (PCW) are at high risk for encephalopathy of prematurity and life-long […]
Kavli Affiliate: Wesley Thompson, Anders Dale | Authors: Pravesh Parekh, Chun Chieh Fan, Oleksandr Frei, Clare E Palmer, Diana M. Smith, Carolina Makowski, John Iverson, Diliana Pecheva, Dominic Holland, Robert Loughnan, Pierre Nedelec, Wesley K Thompson, Donald J. Hagler, Jr., Ole A. Andreassen, Terry L Jernigan, Thomas Nichols and Anders M. Dale | Summary: The […]
Kavli Affiliate: Mark Churchland | Authors: Sean M. Perkins, John P. Cunningham, Qi Wang and Mark M. Churchland | Summary: Decoders for brain-computer interfaces (BCIs) assume constraints on neural activity, chosen to reflect scientific beliefs while yielding tractable computations. We document how low tangling — a typical property of motor-cortex neural trajectories — yields unusual […]
Kavli Affiliate: Rafael Yuste | Authors: Justin Lines and Rafael Yuste | Summary: Neuronal ensembles, defined as groups of coactive neurons, dominate cortical activity and are causally related to perceptual states and behavior. Interestingly, ensembles occur spontaneously in the absence of sensory stimulation. To better understand the function of ensembles in spontaneous activity, we explored […]