Limitations of fluorescent timer proteins toward isolation of developmentally and transcriptionally synchronized populations of human pluripotent stem cells and neural progenitors highlight unique expression and fluorescence maturation kinetics by human cells

Posted by klaurent UCSF

Kavli Affiliate: Seth Shipman | Authors: Manuel Peter, Seth Shipman, Jeffrey D. Macklis | Summary: Differentiation of human pluripotent stem cells (hPSC) into distinct neuronal populations holds substantial potential for disease modeling in vitro, toward both elucidation of pathobiological mechanisms and screening of potential therapeutic agents. For successful differentiation of hPSCs into subtype-specific neurons using […]


Continue.. Limitations of fluorescent timer proteins toward isolation of developmentally and transcriptionally synchronized populations of human pluripotent stem cells and neural progenitors highlight unique expression and fluorescence maturation kinetics by human cells

Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina

Posted by klaurent Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: WPin Lyu, Maria Iribarne, Dmitri Serjanov, Yijie Zhai, Thanh Hoang, Leah J. Campbell, Patrick Boyd, Isabella Palazzo, Mikiko Nagashima, Nicholas J. Silva, Peter F. HItchcock, Jiang Qian, David R. Hyde and Seth Blackshaw | Summary: Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes. This […]


Continue.. Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina

A semi-automated method for quantifying optokinetic reflex tracking acuity

Posted by klaurent Hopkins

Kavli Affiliate: Alex Kolodkin | Authors: James Kenneth Kiraly, Scott C Harris, Timour Al-Khindi, Felice Dunn and Alex L Kolodkin | Summary: The study of murine behavioral responses to visual stimuli is a key component of understanding mammalian visual circuitry. One notable response is the optokinetic reflex (OKR), a highly conserved innate behavior necessary for […]


Continue.. A semi-automated method for quantifying optokinetic reflex tracking acuity

SynGAP regulates synaptic plasticity and cognition independent of its catalytic activity

Posted by klaurent Hopkins

Kavli Affiliate: Richard Huganir | Authors: Yoichi Araki, Kacey E Rajkovich, Elizabeth E Gerber, Timothy R Gamache, Richard C Johnson, Thanh Hai Tran, Bian Liu, Ingie Hong, Alfredo Kirkwood and Richard L Huganir | Summary: SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memory, and cognition. Mutations in SYNGAP1 in […]


Continue.. SynGAP regulates synaptic plasticity and cognition independent of its catalytic activity

Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks

Posted by klaurent Hopkins

Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Maxime Fouyssac, Yvan M Vachez, Yifeng Cheng, Thibault Dufourd, Carole Carcenac, sabrina Boulet, Patricia H Janak, Marc Savasta, David Belin and Sebastien Carnicella | Summary: Impulse control disorders (ICDs), a wide spectrum of maladaptive behavior which includes pathological gambling, hypersexuality and compulsive buying, have been recently suggested […]


Continue.. Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks

Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection

Posted by klaurent Hopkins

Kavli Affiliate: Michael Beer | Authors: Jessica D. Resnick, Jo L. Wilson, Eddy Anaya, Abigail Conte, Maggie Li, William Zhong, Michael A. Beer and Andrew Pekosz | Summary: Primary differentiated human epithelial cell cultures have been widely used by researchers to study viral fitness and virus-host interactions, especially during the COVID19 pandemic. These cultures recapitulate […]


Continue.. Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection

Batch Effects are Causal Effects: Applications in Human Connectomics

Posted by klaurent Hopkins

Kavli Affiliate: Brian Caffo, Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Batch effects, undesirable sources of variance across multiple experiments, present significant challenges for scientific and clinical discoveries. Specifically, batch effects […]


Continue.. Batch Effects are Causal Effects: Applications in Human Connectomics

Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Max Pearson, Carl Haslam, Andrew Fosberry, Emma J Jones, Mark Reglinski, Robert J Edwards, Richard Ashley Lawrenson, Jonathan C Brown, Danuta Mossakowska, James Edward Pease and Shiranee Sriskandan | Summary: The Streptococcus pyogenes cell envelope protease (SpyCEP) is vital to streptococcal pathogenesis and disease progression. Despite its strong association […]


Continue.. Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

Emergent neural dynamics and geometry for generalization in a transitive inference task

Posted by klaurent Columbia

Kavli Affiliate: Daphna Shohamy | Authors: Kenneth Kay, Natalie Biderman, Ramin Khajeh, Manuel Beiran, Christopher J Cueva, Daphna Shohamy, Greg Jensen, Xue-Xin Wei, Vincent P Ferrera and L F Abbott | Summary: Relational cognition — the ability to infer relationships that generalize to novel combinations of objects — is fundamental to human and animal intelligence. […]


Continue.. Emergent neural dynamics and geometry for generalization in a transitive inference task

Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks

Posted by klaurent Hopkins

Kavli Affiliate: Adam S. Charles | Authors: Ahmed El Hady, Daniel Y Takahashi, Ruolan Sun, Oluwateniola Akinwale, Tyler Boyd-Meredith, Yisi Zhang, Adam Charles and Carlos Brody | Summary: Functional ultrasound imaging (fUS) is an emerging imaging technique that indirectly measures neural activity via changes in blood volume. To date it has not been used to […]


Continue.. Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks