A series of spontaneously blinking dyes for super-resolution microscopy

Kavli Affiliate: Timothy Brown | Authors: Katie L. Holland, Sarah E. Plutkis, Timothy A. Daugird, Abhishek Sau, Jonathan B. Grimm, Brian P. English, Qinsi Zheng, Sandeep Dave, Fariha Rahman, Liangqi Xie, Peng Dong, Ariana N. Tkachuk, Timothy A. Brown, Robert H. Singer, Zhe J. Liu, Catherine G. Galbraith, Siegfried M. Musser, Wesley R. Legant and […]


Continue.. A series of spontaneously blinking dyes for super-resolution microscopy

Spatial context non-uniformly modulates inter-laminar communication in the primary visual cortex

Kavli Affiliate: Anirvan Nandy | Authors: Xize Xu, Mitchell P Morton, Nyomi Hudson, Anirvan Nandy and Monika P. Jadi | Summary: Our visual experience is a result of the concerted activity of neuronal ensembles in the sensory hierarchy. Yet how the spatial organization of objects influences neural activity in this hierarchy remains poorly understood. We […]


Continue.. Spatial context non-uniformly modulates inter-laminar communication in the primary visual cortex

The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain

Kavli Affiliate: Li Zhao | Authors: Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sayal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai, Simon O Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim and Victoria Eugenia Guadalupe Abraira | Summary: Tactile perception relies on reliable transmission and modulation […]


Continue.. The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain

The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions

Kavli Affiliate: Li Zhao | Authors: Junhui Peng, Nicolas Svetec, Henrik Molina and Li Zhao | Summary: Post-mating responses play a vital role in successful reproduction across diverse species. In fruit flies, sex peptide (SP) binds to sex peptide receptor (SPR), triggering a series of post-mating responses. However, the origin of SPR predates the emergence […]


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Rejuvenating silicon probes for acute electrophysiology

Kavli Affiliate: Reza Shadmehr | Authors: Alden Shoup, Natasha Porwal, Mohammad Amin Fakharian, Paul Hage, Simon P Orozco and Reza Shadmehr | Summary: Electrophysiological recording with a new probe often yields better signal quality than with a used probe. Why does the signal quality degrade after only a few experiments? Here, we considered silicon probes […]


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Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s Disease

Kavli Affiliate: Alexandra Nelson | Authors: Xiaowen Zhuang, Julia Lemak, Sadhana Sridhar and Alexandra B Nelson | Summary: Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive deficits, this coordination is […]


Continue.. Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s Disease

C. elegans LIN-66 mediates EIF-3.G-dependent protein translation via a cold-shock domain

Kavli Affiliate: Yishi Jin | Authors: Yishi Jin, Stephan M Blazie, Daniel Fortunati and Yan Zhao | Summary: Protein translation initiation is a complex and conserved process involving many proteins acting in concert. The eukaryotic initiation factor 3 (eIF3) complex is essential for the assembly of the pre-initiation complex that scans and positions mRNA at […]


Continue.. C. elegans LIN-66 mediates EIF-3.G-dependent protein translation via a cold-shock domain

A Systematically Optimized Miniaturized Mesoscope (SOMM) for large-scale calcium imaging in freely moving mice

Kavli Affiliate: Alipasha Vaziri | Authors: Yaunlong Zhang, Lekang Yuan, Jiamin Wu, Tobias Noebauer, Rujin Zhang, Guihua Xiao, Mingrui Wang, Hao Xie, Qionghai Dai and Alipasha Vaziri | Summary: Understanding how neuronal dynamics gives rise to ethologically relevant behavior requires recording of neuronal population activity via technologies that are compatible with unconstrained animal behavior. However, […]


Continue.. A Systematically Optimized Miniaturized Mesoscope (SOMM) for large-scale calcium imaging in freely moving mice

Voice patches in the marmoset auditory cortex revealed by wide-field calcium imaging

Kavli Affiliate: Xiaoqin Wang | Authors: Yang Zhang, Xindong Song, Yueqi Guo, Chenggang Chen, Michael S Osmanski and Xiaoqin Wang | Summary: Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive […]


Continue.. Voice patches in the marmoset auditory cortex revealed by wide-field calcium imaging

Towards robust and generalizable representations of extracellular data using contrastive learning

Kavli Affiliate: Liam Paninski | Authors: Ankit Vishnubhotla, Charlotte Loh, Liam Paninski, Akash Srivastava and Cole Lincoln Hurwitz | Summary: Contrastive learning is quickly becoming an essential tool in neuroscience for extracting robust and meaningful representations of neural activity. Despite numerous applications to neuronal population data, there has been little exploration of how these methods […]


Continue.. Towards robust and generalizable representations of extracellular data using contrastive learning