Reverse Engineering of Feedforward Cortical-Hippocampal Microcircuits for Modelling Neural Network Function and Dysfunction

Posted by dbos NTNU

Kavli Affiliate: Menno Witter | Authors: Katrine Sjaastad Hanssen, Nicolai Winter-Hjelm, Salome Nora Niethammer, Asgeir Kobro-Flatmoen, Menno P. Witter, Axel Sandvig and Ioanna Sandvig | Summary: Engineered biological neural networks are indispensable models for investigation of neural function and dysfunction from the subcellular to the network level. Notably, advanced neuro-engineering approaches are of significant interest […]


Continue.. Reverse Engineering of Feedforward Cortical-Hippocampal Microcircuits for Modelling Neural Network Function and Dysfunction

Automated 3D analysis of social head-gaze behaviors in freely moving marmosets

Posted by klaurent Yale

Kavli Affiliate: Anirvan Nandy | Authors: Feng Xing, Alec Graham Sheffield, Monika P. Jadi, Steve W. C. Chang and Anirvan S. Nandy | Summary: Social communication relies on the ability to perceive and interpret the direction of others’ attention, which is commonly conveyed through head orientation and gaze direction in both humans and non-human primates. […]


Continue.. Automated 3D analysis of social head-gaze behaviors in freely moving marmosets

Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

Posted by klaurent Rockefeller

Kavli Affiliate: Mary E. Hatten | Authors: Michalina Hanzel, Kayla Fernando, Susan E Maloney, Shioaching Gong, Kärt Mätlik, Jiajia Zhao, H Amalia Pasolli, Søren Heissel, Joseph D Dougherty, Court Hull and Mary E Hatten | Summary: Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and […]


Continue.. Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions

Posted by klaurent Yale

Kavli Affiliate: Marina Picciotto | Authors: Paul Jongseo Lee, Alexa R Soares, Yu Sun, Caroline Fai, Marina Picciotto and Junjie U Guo | Summary: While previous studies suggest that many mRNAs contain more than one translation initiation site (TIS), the biological significance of most alternative TISs and their corresponding protein isoforms (proteoforms) remains undetermined. Here […]


Continue.. Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions

Degron-based bioPROTACs for controlling signaling in CAR T cells

Posted by klaurent UCSF

Kavli Affiliate: Hana El-Samad | Authors: Matthew S Kim, Hersh K Bhargava, Gavin E Shavey, Wendell A Lim, Hana El-Samad and Andrew H Ng | Summary: Chimeric antigen receptor (CAR) T cells have made a tremendous impact in the clinic, but potent signaling through the CAR can be detrimental to treatment safety and efficacy. The […]


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A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

Posted by klaurent Rockefeller

Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Ryan J Farrell, Kirsten G Bredvik, Michael Blake Hoppa, S Thomas Hennegan, Timothy A Brown and Timothy A Ryan | Summary: The endoplasmic reticulum (ER) is an important regulator of Ca2+ in cells and dysregulation of ER calcium homeostasis can lead to numerous pathologies. Understanding how […]


Continue.. A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

Using artificial intelligence to document the hidden RNA virosphere

Posted by klaurent Rockefeller

Kavli Affiliate: Li Zhao | Authors: Xin Hou, Yong He, Pan Fang, Shi-Qiang Mei, Zan Xu, Wei-Chen Wu, Jun-Hua Tian, Shun Zhang, Zhen-Yu Zeng, Qin-Yu Gou, Gen-Yang Xin, Shi-Jia Le, Yin-Yue Xia, Yu-Lan Zhou, Feng-Ming Hui, Yuan-Fei Pan, John-Sebastian Eden, Zhao-Hui Yang, Chong Han, Yue-Long Shu, Deyin Guo, Jun Li, Edward C Holmes, Zhao-Rong Li […]


Continue.. Using artificial intelligence to document the hidden RNA virosphere

Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling

Posted by klaurent Rockefeller

Kavli Affiliate: Michael W. Young | Authors: Waruna Thotamune, Sithurandi Ubeysinghe, Kendra Kumar Shrestha, Mahmoud Elhusse Mostafa, Michael C Young and Ajith Karunarathne | Summary: Beta-adrenergic receptors (βARs) are G protein-coupled receptors (GPCRs) that mediate catecholamine-induced stress responses, such as heart rate increase and bronchodilation. In addition to signals from the cell surface, βARs also […]


Continue.. Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling

Pheromone representation in the ant antennal lobe changes with age

Posted by klaurent Rockefeller

Kavli Affiliate: Daniel Kronauer | Authors: Taylor Hart, Lindsey E. Lopes, Dominic D. Frank and Daniel J.C. Kronauer | Summary: While the neural basis of age-related decline has been extensively studied (1–3), less is known about changes in neural function during the pre-senescent stages of adulthood. Adult neural plasticity is likely a key factor in […]


Continue.. Pheromone representation in the ant antennal lobe changes with age

The lateral habenula is required for maternal behavior in the mouse dam

Posted by klaurent Hopkins

Kavli Affiliate: David Linden | Authors: Jessie Benedict, Robert H. Cudmore, David J. Linden, Diarra Oden and Aleah Spruell | Summary: Mammalian parenting is an unusually demanding commitment. How did evolution co-opt the reward system to ensure parental care? Previous work has implicated the lateral habenula (LHb), an epithalamic nucleus, as a potential intersection of […]


Continue.. The lateral habenula is required for maternal behavior in the mouse dam