Kavli Affiliate: Aniruddha Das | Authors: Aniruddha Das, Julie Borovicka, Hale Tobin, Shruti Bhatia, Jacob Icardi, Ghazaal Tahmasebi, Priyanka Agochiya, Shriya Singh, Bruce Trapp and Hod Dana | Summary: Damage to the myelin sheath that protects axons in the central nervous system is a hallmark pathology of demyelinating diseases like multiple sclerosis. Cuprizone-induced demyelination in […]
Kavli Affiliate: Joshua Vogelstein | Authors: Eric W Bridgeford, Jaewon Chung, Robert J Anderson, Ali Mahzarnia, Jacques A Stout, Hae Sol Moon, Zay Yar Han, Joshua T Vogelstein and Alexandra Badea | Summary: Alzheimer’s disease (AD) lacks effective cures and is typically detected after substantial pathological changes have occurred, making intervention challenging. Early detection and […]
Kavli Affiliate: Kristofer Bouchard | Authors: Joel Ye, Fabio Rizzoglio, Adam Smoulder, Hongwei Mao, Xuan Ma, Patrick Marino, Raeed H Chowdhury, Dalton D Moore, Gary Blumenthal, Will Hockeimer, Nicolas G. Kunigk, J Patrick Mayo, Aaron P Batista, Steven M Chase, Adam G Rouse, Michael L. Boninger, Charles Greenspon, Andrew B. Schwartz, Nicholas Hatsopoulos, Lee E […]
Kavli Affiliate: C. David Allis | Authors: Agata Lemiesz Patriotis, Yadira Soto-Feliciano, Douglas Barrows, Laiba Khan, Marylene Leboeuf, Peder Lund, Matthew R Marunde, Annaelle Djomo, Michael-Christopher Keogh, Thomas Carroll, Benjamin Garcia, Alexey A Soshnev and C. David Allis | Summary: Polycomb group proteins maintain gene expression patterns established during early development, with Polycomb Repressive Complex […]
Kavli Affiliate: Michael Keiser | Authors: Parker Grosjean, Kaivalya Shevade, Cuong Nguyen, Sarah Ancheta, Karl Mader, Ivan Franco, Seok-Jin Heo, Greyson Lewis, Steven Boggess, Angelique De Domenico, Erik Ullian, Shawn Shafer, Adam Litterman, Laralynne Przybyla, Michael J Keiser, Jamie Ifkovits, Adam Yala and Martin Kampmann | Summary: High-throughput phenotypic screening has historically relied on manually […]
Kavli Affiliate: Kay Tye | Authors: Christopher R Lee, Gillian A Matthews, Mackenzie E Lemieux, Elizabeth M Wasserlein, Matilde Borio, Raymundo L Miranda, Laurel R Keyes, Gates P Schneider, Caroline Jia, Andrea Tran, Faith Aloboudi, May G Chan, Enzo Peroni, Grace Pereira, Alba López-Moraga, Anna Pall é, Eyal Y Kimchi, Nancy Padilla-Coreano, Romy Wichmann and […]
Kavli Affiliate: Jill Leutgeb | Authors: Mengni Wang, Li Yuan, Stefan Leutgeb and Jill K. Leutgeb | Summary: Mental exploration enables flexible evaluation of potential future choices, guiding decision-making without requiring direct real-world iterations. Although the hippocampus is known to be active while imagining the future, the precise mechanisms that support mental exploration of future […]
Kavli Affiliate: V. S. Ramachandran | Authors: Nannan Wang, Franklin P. Ockerman, Laura Y. Zhou, Megan L Grove, Taryn Alkis, John Barnard, Russell P. Bowler, Clary B. Clish, Shinhye Chung, Emily Drzymalla, Anne M. Evans, Nora Franceschini, Robert E. Gerszten, Madeline G. Gillman, Scott R. Hutton, Rachel S. Kelly, Charles Kooperberg, Martin G. Larson, Jessica […]
Kavli Affiliate: Yifan Cheng | Authors: Junrui Li, Yifei chen, Shawn Zheng, Angus McDonald, John W. Sedat, David A. Agard and Yifan Cheng | Summary: With technological advancements in recent years, single particle cryogenic electron microscopy (cryo-EM) has become a major methodology for structural biology. Structure determination by single particle cryo-EM is premised on randomly […]
Kavli Affiliate: Michael Shadlen | Authors: Ariel Zylberberg and Michael N Shadlen | Summary: Confidence in a decision is the belief, prior to feedback, that one’s choice is correct. In the brain, many decisions are implemented as a race between competing evidence-accumulation processes. We ask whether the neurons that represent evidence accumulation also carry information […]