Kavli Affiliate: Kevin Yackle | Authors: Alastair MacDonald and Kevin Yacklei | Summary: Intonation in speech is the control of vocal pitch to layer expressive meaning to communication, like increasing pitch to indicate a question. Also, stereotyped patterns of pitch are used to create distinct “words”, like the ten sounds in the murine lexicon. A […]
Kavli Affiliate: Attila Losonczy | Authors: Stephanie A Herrlinger, Bovey Rao, Margaret E Conde Paredes, Anna L Tuttman, Haroon Arain, Erdem Varol, Joseph A Gogos and Attila Losonczy | Summary: Individuals with the 22q11.2 deletion syndrome, one of the strongest genetic risk factors for schizophrenia, demonstrate cognitive impairments such as episodic memory dysfunction. Place cell […]
Kavli Affiliate: Jeffrey M. Friedman | Authors: Santiago R Unda, Roberta Marongiu, Lisa E Pomeranz, Jonathan P Dyke, Edward K Fung, Logan Grosenick, Rick Zirkel, Aldana M Antoniazzi, Sofya Norman, Conor M Liston, Chris B Schaffer, Nozomi Nishimura, Sarah A Stanley, Jeffrey M Friedman and Michael G Kaplitt | Summary: Regulating the activity of discrete […]
Kavli Affiliate: Michael Beer | Authors: Michael Beer, Ana Sofia F. Oliveira, Catherine L. Tooke, Philip Hinchliffe, Angie Tsz Yan Li, Balazs Balega, James Spencer and Adrian J Mulholland | Summary: β-Lactamases, which hydrolyse β-lactam antibiotics, are key determinants of antibiotic resistance. Predicting the sites and effects of distal mutations in enzymes is challenging. For […]
Kavli Affiliate: Li Zhao | Authors: UnJin Lee, Cong Li, Christopher B Langer, Nicolas Svetec and Li Zhao | Summary: Spermatogenesis is a key developmental process underlying the origination of newly evolved genes. However, rapid cell type-specific transcriptomic divergence of the Drosophila germline has posed a significant technical barrier for comparative single-cell RNA-sequencing (scRNA-Seq) studies. […]
Kavli Affiliate: Marcelo Mattar | Authors: Kristopher T. Jensen, Guillaume Hennequin and Marcelo G. Mattar | Summary: When interacting with complex environments, humans can rapidly adapt their behavior to changes in task or context. To facilitate this adaptation, we often spend substantial periods of time contemplating possible futures before acting. For such planning to be […]
Kavli Affiliate: Keri Martinowich | Authors: Erik D. Nelson, Madhavi Tippani, Anthony D. Ramnauth, Heena R. Divecha, Ryan A. Miller, Nicholas J. Eagles, Elizabeth A. Pattie, Sang Ho Kwon, Svitlana V. Bach, Uma M. Kaipa, Jianing Yao, Joel E. Kleinman, Leonardo Collado-Torres, Shizhong Han, Kristen R. Maynard, Thomas M. Hyde, Keri Martinowich, Stephanie C. Page […]
Kavli Affiliate: Robert Edwards | Authors: Linzi Hosohama, Delia F. Tifrea, Kevin Nee, Sung Yun Park, Jie Wu, Amber N. Habowski, Cassandra Van, Marcus M. Seldin, Robert A. Edwards and Marian L. Waterman | Summary: Several classification systems have been developed to define tumor subtypes in colorectal cancer (CRC). One system proposes that tumor heterogeneity […]
Kavli Affiliate: Yishi Jin | Authors: Dana T Byrd, Ziyuan Christina Han, Christopher A Piggott and Yishi Jin | Summary: PACS (Phosphofurin Acidic Cluster Sorting Protein) proteins are known for their roles in sorting cargo proteins to organelles and can physically interact with WD40 repeat-containing protein WDR37. PACS1, PACS2, and WDR37 variants are associated with […]
Kavli Affiliate: Thomas P. Sakmar | Authors: Rhonda K Roby, Rosana A Wiscovitch-Russo, Rebecca Hart, Amanda E Appel, Manija A Kazmi, Thomas Huber, Karina C Åberg, Thomas P Sakmar, José A Lorente and Norberto Gonzalez-Juarbe | Summary: The genomic analysis of biological material obtained from artwork or cultural heritage artifacts can be used to guide […]