Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing

Posted by dbos Columbia

Kavli Affiliate: Liam Paninski | Authors: Marcus A Triplett, Marta Gajowa, Benjamin Antin, Masato Sadahiro, Hillel Adesnik and Liam Paninski | Summary: Discovering how neural computations are implemented in the cortex at the level of monosynaptic connectivity requires probing for the existence of synapses from possibly thousands of presynaptic candidate neurons. Two-photon optogenetics has been […]


Continue.. Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing

Long-Term Effects of Early Adolescent Second-Generation Antipsychotic Exposure on Body Weight, Caloric Intake, and Metabolism-Associated Gene Expression

Posted by dbos Rockefeller

Kavli Affiliate: Michael W. Young | Authors: Paul Soto, Michael E Young, Serena Nguyen, Megan Federoff, Mia M Goodson, Christopher D Morrison, Heidi Batdorf, Susan Burke and Jason Collier | Summary: The use of second-generation antipsychotic (SGA) medications in pediatric patients raises concerns about potential long-term adverse outcomes. The current study evaluated the long-term effects […]


Continue.. Long-Term Effects of Early Adolescent Second-Generation Antipsychotic Exposure on Body Weight, Caloric Intake, and Metabolism-Associated Gene Expression

Brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

Posted by dbos Hopkins, UCSD / Salk

Kavli Affiliate: Timothy Brown and Richard Huganir | Authors: Boaz Mohar, Gabriela Michel, Yi-Zhi Wang, Veronica Hernandez, Jonathan B. Grimm, Jin-Yong Park, Ronak Patel, Morgan Clarke, Timothy A. Brown, Cornelius Bergmann, Kamil K. Gebis, Anika P. Wilen, Bian Liu, Ricard Johnson, Austin Graves, Tatjana Tchumatchenko, Jeffrey N. Savas, Eugenio F. Fornasiero, Richard L. Huganir, Paul […]


Continue.. Brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

Modular representations emerge in neural networks trained to perform context-dependent tasks

Posted by dbos Columbia

Kavli Affiliate: Stefano Fusi | Authors: W. Jeffrey Johnston and Stefano Fusi | Summary: The brain has a well-known large scale organization at the level of brain regions, where different regions have been argued to primarily serve different behavioral functions. This regional specialization has been explained theoretically as arising from constraints on connectivity and the […]


Continue.. Modular representations emerge in neural networks trained to perform context-dependent tasks

Endosomal hyper-acidification via proton-activated chloride channel deletion in neurons impairs AMPA receptor endocytosis and LTD

Posted by dbos Hopkins

Kavli Affiliate: Richard Huganir | Authors: Kevin Chen, Junhua Yang, Bian Liu, Chaohua Jiang, Nicholas Koylass, Zhe Zhang, Shuying Sun, Richard L. Huganir and Zhaozhu Qiu | Summary: Endosomal homeostasis is critical for neuronal function, including the post-synaptic trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). Dynamic AMPAR trafficking is a major component of synaptic plasticity, such […]


Continue.. Endosomal hyper-acidification via proton-activated chloride channel deletion in neurons impairs AMPA receptor endocytosis and LTD

Latent-TGF-β has a domain swapped architecture

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Mingliang Jin, Robert Seed, Tiffany Shing, Yifan Cheng and Stephen Nishimura | Summary: The multifunctional cytokine TGF-β is produced in a latent form (L-TGF-β) where a RGD containing homodimeric prodomain forms a “ring” encircling mature TGF-β shielding it from its receptors. Thus L-TGF-β must be activated to function, a […]


Continue.. Latent-TGF-β has a domain swapped architecture

Dysregulation of the fluid homeostasis system by aging

Posted by dbos UCSF

Kavli Affiliate: Zachary Knight | Authors: Heeun Jang, Alexis Behne Sharma, Usan Dan, Jasmine H. Wong, Zachary A. Knight and Jennifer L. Garrison | Summary: Chronic dehydration is a leading cause of morbidity for the elderly, but how aging alters the fluid homeostasis system is not well understood. Here, we used a combination of physiologic, […]


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Nucleoprotein phase-separation affinities revealed via atomistic simulations of short peptide and RNA fragments

Posted by dbos UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Vysakh Ramachandran, William Brown and Davit A Potoyan | Summary: Liquid-liquid phase separation of proteins and nucleic acids into condensate phases is a versatile mechanism for ensuring compartmentalization of cellular biochemistry. RNA molecules play critical roles in these condensates, particularly in transcriptional regulation and stress responses, exhibiting a […]


Continue.. Nucleoprotein phase-separation affinities revealed via atomistic simulations of short peptide and RNA fragments

Oxytocin receptor controls distinct components of pair bonding and development in prairie voles

Posted by dbos UCSF

Kavli Affiliate: Devanand Manoli and Jeremy Willsey | Authors: Ruchira Sharma, Kristen M. Berendzen, Amanda Everitt, Belinda Wang, Gina Williams, Shuyu Wang, Kara Quine, Rose D. Larios, Kimberly L. P. Long, Nerissa Hoglen, Bibi Alika Sulaman, Marie C. Heath, Michael Sherman, Matthew Kinkel, Angela Cai, Denis Galo, Lizandro Chan Caamal, Nastacia L. Goodwin, Annaliese Beery, […]


Continue.. Oxytocin receptor controls distinct components of pair bonding and development in prairie voles

Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

Posted by dbos UCSF

Kavli Affiliate: Michael Keiser | Authors: Sina Ghandian, Liane Albarghouthi, Kiana Nava, Shivam R. Rai Sharma, Lise Minaud, Laurel Beckett, Naomi Saito, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Lee-Way Jin, Brittany N. Dugger and Michael J. Keiser | Summary: Accumulation of abnormal tau protein into neurofibrillary tangles (NFTs) is a pathologic hallmark of […]


Continue.. Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations