Role of dopamine in reward expectation and predictability during execution of action sequences

Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Yifeng Cheng, Joanna Zhou, Haley Province, Nathalie Thiriet, Patricia H Janak and Youna Vandaele | Summary: Reward-associated cues serve different functions depending on whether they precede or terminate action sequences. Cues that precede action sequences and signal opportunity for reward could serve as GO signals to initiate […]


Continue.. Role of dopamine in reward expectation and predictability during execution of action sequences

HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s Disease

Kavli Affiliate: Michael Miller | Authors: Emmanuel C Ijezie, Michael J Miller, Celine Hardy, Ava R Jarvis, Timothy Czajka, Lianna D’Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy and David Butler | Summary: INTRODUCTION Herpes simplex virus 1 (HSV-1) infection alters critical markers of Alzheimer’s Disease (AD) in neurons. One key marker of AD is the […]


Continue.. HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer’s Disease

Early auditory and adult mating experiences interact with singer identity to shape neural responses to song in female zebra finches

Kavli Affiliate: Sarah Woolley | Authors: Isabella Catalano and Sarah C Woolley | Summary: Social and sensory experiences across the lifespan can shape social interactions, however, experience-dependent plasticity is widely studied within discrete life stages. In the socially monogamous zebra finch, in which females use learned vocal signals to identify individuals and form long-lasting pair […]


Continue.. Early auditory and adult mating experiences interact with singer identity to shape neural responses to song in female zebra finches

Discovering Cognitive Strategies with Tiny Recurrent Neural Networks

Kavli Affiliate: Marcelo Mattar | Authors: Li Ji-An, Marcus K Benna and Marcelo G Mattar | Summary: Normative modeling frameworks such as Bayesian inference and reinforcement learning provide valuable insights into the fundamental principles governing adaptive behavior. While these frameworks are valued for their simplicity and interpretability, their reliance on few parameters often limits their […]


Continue.. Discovering Cognitive Strategies with Tiny Recurrent Neural Networks

Complete sequencing of ape genomes

Kavli Affiliate: Erich Jarvis | Authors: DongAhn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A. Logsdon, Steven J. Solar, Dmitry Antipov, Brandon D. Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M. Storer, Jiadong Lin, Abigail N. Sequeira, Riley J. Mangan, Glenn Hickey, Graciela Monfort Anez, Parithi Balachandran, Anton Bankevich, Christine R. […]


Continue.. Complete sequencing of ape genomes

Why do we have so many excitatory neurons?

Kavli Affiliate: Carey Priebe and Joshua Vogelstein | Authors: Qingyang Wang, Albert Cardona, Marta Zlatic, Joshua Vogelstein and Carey Priebe | Summary: Approximately four in five neurons are excitatory. This is true across functional regions and species. Why do we have so many excitatory neurons? Little is known. Here we provide a normative answer to […]


Continue.. Why do we have so many excitatory neurons?

Quantifying transcriptome turnover on phylogenies by modeling gene expression as a binary trait

Kavli Affiliate: Li Zhao | Authors: Ammon Thompson, Michael R. May, Ben Hopkins, Nerisa Riedl, Olga Barmina, Benjamin J. Liebeskind, Li Zhao, David Begun and Artyom Kopp | Summary: Changes in gene expression are a key driver of phenotypic evolution, leading to a persistent interest in the evolution of transcriptomes. Traditionally, gene expression is modeled […]


Continue.. Quantifying transcriptome turnover on phylogenies by modeling gene expression as a binary trait

Bi-level Graph Learning Unveils Prognosis-Relevant Tumor Microenvironment Patterns in Breast Multiplexed Digital Pathology

Kavli Affiliate: Jeremias Sulam | Authors: Zhenzhen Wang, Cesar A. Santa-Maria, Aleksander S. Popel and Jeremias Sulam | Summary: The tumor microenvironment is widely recognized for its central role in driving cancer progression and influencing prognostic outcomes. There have been increasing efforts dedicated to characterizing this complex and heterogeneous environment, including developing potential prognostic tools […]


Continue.. Bi-level Graph Learning Unveils Prognosis-Relevant Tumor Microenvironment Patterns in Breast Multiplexed Digital Pathology

Robust Detection of Brain Stimulation Artifacts in iEEG Using Autoencoder-Generated Signals and ResNet Classification

Kavli Affiliate: Edward Chang | Authors: Jeremy Saal, Ankit N. Khambhati, Edward F. Chang and Prasad Shirvalkar | Summary: Background Intracranial EEG (iEEG) is crucial for understanding brain function, but stimulation-induced noise complicates data interpretation. Traditional artifact detection methods require manual user input or struggle with noise variability, especially with limited labeled data. Objective We […]


Continue.. Robust Detection of Brain Stimulation Artifacts in iEEG Using Autoencoder-Generated Signals and ResNet Classification

Like mother, like daughter? Phenotypic plasticity, environmental covariation, and heritability of size in a parthenogenetic wasp

Kavli Affiliate: William Kristan | Authors: Alicia Tovar, Scott Monahan, Adrian Kristan, Walker Welch, Ryan Dettmers, Camila Arce, Theresa Buck, Michele Ruben, Alexander Rothenberg, Roxane Saisho, Ryan Cartmill, Timothy Skaggs, Robert Reyes, MJ Lee, John J Obrycki, William Kristan and Arun Sethuraman | Summary: Abstract Dinocampus coccinellae (Hymenoptera:Braconidae, Euphorinae) is a solitary, generalist Braconid parasitoid […]


Continue.. Like mother, like daughter? Phenotypic plasticity, environmental covariation, and heritability of size in a parthenogenetic wasp