Purkinje cells in Crus I and II encode the visual stimulus and the impending choice as monkeys learn a reinforcement based visuomotor association task

Posted by dbos Columbia

Kavli Affiliate: Stefano Fusi and Michael Goldberg | Authors: Anna Ipata, Valeria Fascianelli, Chris I De Zeeuw, Naveen Sendhilnathan, Stefano Fusi and Michael E. Goldberg | Summary: Visuomotor association involves linking an arbitrary visual cue to a well-learned movement. Transient inactivation of Crus I/II impairs primates’ ability to learn new associations and delays motor responses […]


Continue.. Purkinje cells in Crus I and II encode the visual stimulus and the impending choice as monkeys learn a reinforcement based visuomotor association task

Neurovascular Impulse Response Function (IRF) during spontaneous activity differentially reflects intrinsic neuromodulation across cortical regions

Posted by dbos Caltech, UCSD / Salk

Kavli Affiliate: David Kleinfeld | Bradley C. Rauscher, Natalie Fomin-Thunemann, Sreekanth Kura, Patrick R. Doran, Pablo D. Perez, Kıvılcım Kılıç, Emily A. Martin, Dora Balog, Nathan X. Chai, Francesca A. Froio, Patrick F. Bloniasz, Kate E. Herrema, Rockwell Tang, Scott G. Knudstrup, Andrew Garcia, John X. Jiang, Jeffrey P. Gavornik, David Kleinfeld, Michael E. Hasselmo, […]


Continue.. Neurovascular Impulse Response Function (IRF) during spontaneous activity differentially reflects intrinsic neuromodulation across cortical regions

Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Posted by dbos Hopkins

Kavli Affiliate: Jean Fan | Authors: Rafael dos Santos Peixoto, Brendan F Miller, Maigan A Brusko, Gohta Aihara, Lyla Atta, Manjari Anant, Mark A Atkinson, Todd M Brusko, Clive H Wasserfall and Jean Fan | Summary: Spatially resolved omics (SRO) technologies enable the identification of cell types while preserving their organization within tissues. Application of […]


Continue.. Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Cholinergic feedback for context-specific modulation of sensory representations

Posted by dbos UCSD / Salk

Kavli Affiliate: Takaki Komiyama | Authors: Bin Yu, Yuxuan Yue, Chi Ren, Rui Yun, Byungkook Lim and Takaki Komiyama | Summary: The brain’s ability to prioritize behaviorally relevant sensory information is crucial for adaptive behavior, yet the underlying mechanisms remain unclear. Here, we investigated the role of basal forebrain cholinergic neurons in modulating olfactory bulb […]


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Brain state and cortical layer-specific mechanisms underlying perception at threshold

Posted by klaurent UCSD / Salk, Yale

Kavli Affiliate: Anirvan Nandy, John Reynolds | Authors: Mitchell P Morton, Sachira Denagamage, Isabel J Blume, John H Reynolds, Monika P Jadi and Anirvan S Nandy | Summary: Identical stimuli can be perceived or go unnoticed across successive presentations, producing divergent behavioral outcomes despite similarities in sensory input. We sought to understand how fluctuations in […]


Continue.. Brain state and cortical layer-specific mechanisms underlying perception at threshold

Multiple and subject-specific roles of uncertainty in reward-guided decision-making

Posted by dbos UCSD / Salk

Kavli Affiliate: Angela Yu | Authors: Alexander Paunov, Maëva L’Hôtellier, Zoe He, Dalin Guo, Angela Yu and Florent Meyniel | Summary: Decision-making in noisy, changing, and partially observable environments entails a basic tradeoff between immediate reward and longer-term information gain, known as the exploration-exploitation dilemma. Computationally, an effective way to balance this tradeoff is by […]


Continue.. Multiple and subject-specific roles of uncertainty in reward-guided decision-making

Neuromodulators generate multiple context-relevant behaviors in a recurrent neural network by shifting activity flows in hyperchannels

Posted by dbos UCSD / Salk

Kavli Affiliate: Kay Tye and Terrence Sejnowski | Authors: Ben Tsuda, Stefan C Pate, Kay M Tye, Hava T Siegelmann and Terrence J Sejnowski | Summary: Neuromodulators are critical controllers of neural states, with dysfunctions linked to various neuropsychiatric disorders. Although many biological aspects of neuromodulation have been studied, the computational principles underlying how neuromodulation […]


Continue.. Neuromodulators generate multiple context-relevant behaviors in a recurrent neural network by shifting activity flows in hyperchannels

Spontaneously regenerative corticospinal neurons in mice

Posted by dbos Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Benjamin W Fait, Bianca Cotto, Tatsuya C Murakami, Michael Hagemann-Jensen, Huiqing Zhan, Corinne Freivald, Isadora Turbek, Yuan Gao, Zizhen Yao, Sharon W Way, Hongkui Zeng, Bosiljka Tasic, Oswald Steward, Nathaniel Heintz and Eric F Schmidt | Summary: The spinal cord receives inputs from the cortex via corticospinal neurons (CSNs). […]


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Inhibition mediated by group III mGluRs regulates habenula activity and defensive behaviors

Posted by dbos NTNU

Kavli Affiliate: Emre Yaksi | Authors: Anna Maria Ostenrath, Nicholas Faturos, Yagnur Isik Ciftci Cobanoglu, Bram Serneels, Inyoung Jeong, Anja Enz, Francisca Hinrichsen, Aytac Kadir Mutlu, Ricarda Bardenhewer, Suresh Kumar Jetti, Stephan C. F. Neuhauss, Nathalie Jurisch-Yaksi and Emre Yaksi | Summary: Inhibition contributes to various brain computations from sensory motor transformations to cognitive operations. […]


Continue.. Inhibition mediated by group III mGluRs regulates habenula activity and defensive behaviors

A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes

Posted by dbos Yale

Kavli Affiliate: Shawn Ferguson | Authors: Amanda Bentley-DeSousa and Shawn Ferguson | Summary: Mutations that increase LRRK2 kinase activity have been linked to Parkinson’s disease and Crohn’s disease. LRRK2 is also activated by lysosome damage evoked by chemical and pathogenic stimuli. However, the endogenous cellular mechanisms that control LRRK2 kinase activity are not well understood. […]


Continue.. A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes