Neuroscience – Page 144 – Kavli Institute Pre-Print Publications

Enzyme-Responsive Nanoparticles for the Targeted Delivery of an MMP Inhibitor to the Heart post Myocardial Infarction

Posted by klaurent March 7, 2022March 21, 2022UCSD / Salk

Kavli Affiliate: Karen Christman | Authors: Holly Sullivan, Yifei Liang, Kendra Worthington, Colin Luo, Nathan C Gianneschi and Karen Christman | Summary: In this paper, we describe block copolymer amphiphiles consisting of a hydrophilic matrix metalloproteinase (MMP) peptide substrate, and a hydrophobic small molecule MMP inhibitor PD166793 for the treatment of acute myocardial infarction. These […]

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Automated assembly of high-quality diploid human reference genomes

Posted by klaurent March 6, 2022March 10, 2022Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Erich D. Jarvis, Giulio Formenti, Arang Rhie, Andrea Guarracino, Chentao Yang, Jonathan Wood, Alan Tracey, Francoise Thibaud-Nissen, Mitchell R Vollger, David Porubsky, Haoyu Cheng, Mobin Asri, Glennis A Logsdon, Paolo Carnevali, Mark Chaisson, Chen-Shan Chin, Sarah Cody, Joanna Collins, Peter Ebert, Merly Escalona, Olivier Fedrigo, Robert S Fulton, Lucinda […]

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Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson’s Disease: Predictions and Validation of a Patient-Specific Non-Linear Model

Posted by klaurent March 4, 2022March 10, 2022UCSF

Kavli Affiliate: Philip Starr | Authors: James J. Sermon, Maria Olaru, Juan Anso, Simon Little, Rafal Bogacz, Philip A. Starr, Timothy Denison and Benoit Duchet | Summary: Background Entrainment of brain oscillations has been hypothesised as a potential mechanism of neuromodulation. While neuromodulation has been shown to be an effective therapy for a variety of […]

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Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology

Posted by klaurent March 2, 2022December 19, 2022Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E. Greene, Pietro De Camilli and Mian Cao | Summary: Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically enriched clathrin-uncoating factors, synaptojanin 1 […]

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Reconstitution of renal cyst formation in 3D culture reveals a role for AMOT and Yap1 in determining cyst size.

Posted by klaurent March 2, 2022March 10, 2022Columbia

Kavli Affiliate: Wei Min | Authors: Clark D Wells, Kevin Lange, Abigail F Thompson, Wei Min Xu, Sherry G Clendenon, John S Underwood, Peter Harris, Britney-Shea Herbert, James A. Glazier, Angela Wandinger-Ness and Robert L Bacallao | Summary: Despite substantial progress in identifying and understanding causative mutations in autosomal dominant polycystic kidney disease (ADPKD), little […]

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Synergistic effect of mutations in the Parkinson’s disease-linked proteins synaptojanin 1 and auxilin

Posted by klaurent March 2, 2022March 10, 2022Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E. Greene, Pietro De Camilli and Mian Cao | Summary: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically-enriched clathrin-uncoating factors, synaptojanin 1 (SJ1) and […]

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Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction

Posted by klaurent March 2, 2022March 10, 2022UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Guy Hindley, Alexey A Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Borge Holen, Thomas Bjella, Chun Chieh Fan, Torill Uelan, Srdjan Djurovic, Olav B Smeland, Oleksandr Frei, Anders Dale and Ole Andreassen | Summary: Personality and cognition are […]

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Rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought

Posted by klaurent March 2, 2022March 10, 2022Rockefeller

Kavli Affiliate: Li Zhao, Margaret Herre | Authors: Krithika Venkataraman, Nadav Shai, Priyanka Lakhiani, Sarah Zylka, Jieqing Zhao, Margaret Herre, Joshua Zeng, Lauren A Neal, Henrik Molina, Li Zhao and Leslie B Vosshall | Summary: Female Aedes aegypti mosquitoes impose a severe global public health burden as vectors of multiple viral pathogens. Under optimal environmental […]

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Cell-specific regulation of gene expression using splicing-dependent frameshifting.

Posted by klaurent March 2, 2022March 10, 2022Hopkins

Kavli Affiliate: Dwight Bergles, Seth Blackshaw, Richard Huganir, Patrick Kanold, Kristina Nielsen | Authors: Jonathan Ling, Alexei Bygrave, Clayton Santiago, Rogger Carmen, Vickie Trinh, Minzhong Yu, Yini Li, Jeong Han, Kamil Taneja, Ying Liu, Rochinelle Dongmo, Travis Babola, Patrick Parker, Lizhi Jiang, Patrick Leavey, Jennifer Smith, Rachel Vistein, Megan Gimmen, Benjamin Dubner, Patric Teodorescu, THEODOROS […]

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Spatially distributed computation in cortical circuits

Posted by klaurent March 1, 2022March 10, 2022UCSD / Salk

Kavli Affiliate: Thomas Albright | Authors: Sergei Gepshtein, Ambarish Pawar, Sunwoo Kwon, Sergey Savel’ev and Thomas D Albright | Summary: The traditional view of neural computation in the cerebral cortex holds that sensory neurons are specialized, i.e., selective for certain dimensions of sensory stimuli. This view was challenged by evidence of contextual interactions between stimulus […]

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