Using Biological Constraints to Improve Prediction in Precision Oncology

Kavli Affiliate: Donald Geman, Laurent Younes | Authors: Mohamed Omar, Wikum Dinalankara, Lotte Mulder, Tendai Coady, Claudio Zanettini, Eddie Luidy Imada, Laurent Younes, Donald Geman and Luigi Marchionni | Summary: Abstract Many gene signatures have been developed by applying machine learning (ML) on omics profiles, however, their clinical utility is often hindered by limited interpretability […]


Continue.. Using Biological Constraints to Improve Prediction in Precision Oncology

Heritable differences in synaptic zinc-transporter levels drive variation in learned birdsong

Kavli Affiliate: Michael Brainard | Authors: DG. Mets, W. H. Mehaffey, B. M. Colquitt and M. S. Brainard | Summary: Abstract The authors have withdrawn this manuscript. During revision of our manuscript, we carried out several lines of additional experiments and analyses that failed to fully support and reproduce the results previously presented in Figure […]


Continue.. Heritable differences in synaptic zinc-transporter levels drive variation in learned birdsong

Alzheimer’s-associated upregulation of mitochondria-associated ER membranes after traumatic brain injury

Kavli Affiliate: Daphna Shohamy | Authors: Jonathan Nicholas, Christian Amlang, Chi-Ying Lin, Leila Montaser-Kouhsari, Natasha Desai, Ming-Kai Pan, Sheng-Han Kuo and Daphna Shohamy | Summary: Abstract Traumatic brain injury (TBI) can lead to neurodegenerative diseases such as Alzheimer’s disease (AD) through mechanisms that remain incompletely characterized. Similar to AD, TBI models present with cellular metabolic […]


Continue.. Alzheimer’s-associated upregulation of mitochondria-associated ER membranes after traumatic brain injury

Age-specific mechanisms regulate neural crest and mesodermal contribution to the enteric nervous system in health and disease

Kavli Affiliate: Loyal Goff | Authors: Subhash Kulkarni, Monalee Saha, Alpana Singh, Jared Slosberg, Sushma Nagaraj, Laren S Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna Leser, Mithra Kumar, Shriya Bakhshi, Matthew J Anderson, Mark Lewandoski, Elizabeth Vincent, Loyal Goff and Pankaj Jay Pasricha | Summary: Abstract The enteric nervous system (ENS), a […]


Continue.. Age-specific mechanisms regulate neural crest and mesodermal contribution to the enteric nervous system in health and disease

Phase alignment of low-frequency neural activity to the amplitude envelope of speech reflects evoked responses to acoustic edges, not oscillatory entrainment

Kavli Affiliate: Edward Chang | Authors: Yulia Oganian, Katsuaki Kojima, Assaf Breska, Chang Cai, Anne Findlay, Edward F Chang and Srikantan Nagarajan | Summary: Abstract The amplitude envelope of speech is crucial for accurate comprehension. Considered a key stage in speech processing, the phase of neural activity in the theta-delta bands (1 – 10 Hz) […]


Continue.. Phase alignment of low-frequency neural activity to the amplitude envelope of speech reflects evoked responses to acoustic edges, not oscillatory entrainment