Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy

Posted by klaurent UCSF

Kavli Affiliate: Edward Chang | Authors: DANQING ZHU, David H Brookes, Akosua Busia, Ana Carneiro, Clara Fannjiang, Galina Popova, David Shin, Edward F Chang, Tomasz J. Nowakowski, Jennifer Listgarten and David V Schaffer | Summary: Abstract Adeno-associated viruses (AAVs) hold tremendous promise as delivery vectors for clinical gene therapy, but they need improvement. AAVs with […]


Continue.. Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy

Mitochondria-containing EVs Protect Brain Endothelial Cells and Reduce Mouse Brain Infarct Sizes

Posted by klaurent UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Kandarp Dave, Donna B Stolz, Venugopal R Venna, Victoria A. Quaicoe, Michael E Maniskas, Michael John Reynolds, Riyan Babidhan, Duncan X Dobbins, Maura N. Farinelli, Abigail Sullivan, Tarun N. Bhatia, Hannah Yankello, Rohan Reddy, Younsoo Bae, Rehana K Leak, Sruti Shiva, Louise D McCullough and Devika Soundara Manickam | […]


Continue.. Mitochondria-containing EVs Protect Brain Endothelial Cells and Reduce Mouse Brain Infarct Sizes

Extracellular Vesicle (EV) Mitochondria and EV/HSP27 Mixtures Protect the Ischemic Brain Endothelium

Posted by klaurent UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Kandarp Dave, Donna B Stolz, Michael John Reynolds, Riyan Babidhan, Duncan X Dobbins, Tarun N. Bhatia, Hannah Yankello, Rohan Reddy, Younsoo Bae, Rehana K Leak, Sruti Shiva and Devika Soundara Manickam | Summary: Ischemic stroke causes brain endothelial cell (BEC) death and damages tight junction integrity of the blood-brain […]


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A positively Tuned Voltage Indicator Reveals Electrical Correlates of Calcium Activity in the Brain

Posted by klaurent Columbia

Kavli Affiliate: Attila Losonczy | Authors: S. Wenceslao Evans, Dongqing Shi, Mariya Chavarha, Mark H. Plitt, Jiannis Taxidis, Blake Madruga, Siri C. van Keulen, Michelle M. Pang, Sharon Su, Fuu-Jiun Hwang, Guofeng Zhang, Austin Reese, Lagnajeet Pradhan, Jiang Lan Fan, Sungmoo Lee, Yu Liu, Carl-Mikael Suomivuori, Dongyun Jiang, Adrian Negrean, Sui Wang, Na Ji, Thomas […]


Continue.. A positively Tuned Voltage Indicator Reveals Electrical Correlates of Calcium Activity in the Brain

HERBS: Histological E-data Registration in rodent Brain Spaces

Posted by klaurent NTNU

Kavli Affiliate: Jonathan Whitlock, Jingyi Guo, Pearl Saldanha | Authors: Jingyi Guo Fuglstad, Pearl Saldanha, Jacopo Paglia and Jonathan R. Whitlock | Summary: Abstract Recording technologies for rodents have seen huge advances in the last decade, allowing users to sample thousands of neurons simultaneously from multiple brain regions. This has prompted the need for digital […]


Continue.. HERBS: Histological E-data Registration in rodent Brain Spaces

Signatures of visuospatial information foraging during learning of complex environments

Posted by klaurent Columbia

Kavli Affiliate: Daphna Shohamy | Authors: David L Barack, Akram Bakkour, Daphna Shohamy and C Daniel Salzman | Summary: Abstract In the real world, making sequences of decisions to achieve goals often depends upon the ability to learn aspects of the environment that are not directly perceptible. Learning these so-called latent features requires seeking information […]


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Canonical retinotopic shifts under an inverse force field explain predictive remapping

Posted by klaurent Yale

Kavli Affiliate: Michael Keiser | Authors: Laura M Gunsalus, Michael J. Keiser and Katherine S Pollard | Summary: ABSTRACT Predictive remapping — the ability of cells in retinotopic brain areas to transiently exhibit spatio-temporal retinotopic shifts beyond the spatial extent of their classical receptive fields — has been proposed as a primary mechanism that stabilizes […]


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Rapid fluctuations in functional connectivity of cortical networks encode spontaneous

Posted by klaurent Yale

Kavli Affiliate: Michael Crair, Jessica Cardin | Authors: Hadas Benisty, Daniel Barson, Andrew H. Moberly, Sweyta Lohani, Ronald R. Coifman, Gal Mishne, Michael C. Crair, Jessica A. Cardin and Michael J. Higley | Summary: Abstract Experimental work across a variety of species has demonstrated that spontaneously generated behaviors are robustly coupled to variation in neural […]


Continue.. Rapid fluctuations in functional connectivity of cortical networks encode spontaneous

Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior

Posted by klaurent Yale

Kavli Affiliate: Jessica Cardin & Michael Higley | Authors: Hadas Benisty, Andrew H Moberly, Sweyta Lohani, Daniel Barson, Ronald R Coifman, Gal Mishne, Jessica A Cardin and Michael J Higley | Summary: Abstract Experimental work across a variety of species has demonstrated that spontaneously generated behaviors are robustly coupled to variation in neural activity within […]


Continue.. Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior

Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus

Posted by klaurent UCSF

Kavli Affiliate: Arnold Kriegstein | Authors: Brian R Herb, Hannah J Glover, Aparna Bhaduri, Carlo Colantuoni, Tracy L Bale, Kimberly Siletti, Sten Linnarsson, Rebecca D Hodge, Ed Lein, Arnold Kriegstein, Claudia Doege and Seth A Ament | Summary: Abstract The development and diversity of neuronal subtypes in the human hypothalamus has been insufficiently characterized. We […]


Continue.. Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus