Kavli Affiliate: Li Zhao | Authors: Bo Tian, Yan Bian, De-Jian Bian, Ye Gao, Xun Zhang, Si-Wei Zhou, Yan-Hui Zhang, Ya-Nan Pang, Zhao-Shen Li and Luo-Wei Wang | Summary: ABSTRACT Background As a processing method of RNA precursors, alternative splicing plays a critical role in normal cell physiological activities. Aberrant alternative splicing events are associated […]
Kavli Affiliate: Brian Caffo, Martin Lindquist | Authors: Tanmay Nath, Brian Caffo, Tor Wager and Martin Lindquist | Summary: Abstract Mediation analysis is used to investigate the role of intermediate variables (mediators) that lie in the path between an exposure and an outcome variable. While significant research has focused on developing methods for assessing the […]
Kavli Affiliate: Seth Blackshaw, Loyal Goff | Authors: Jonathan J Augustin, Saki Takayangi, Thanh Hoang, Briana Winer, Seth Blackshaw and Loyal A Goff | Summary: Abstract Ablation of the long non-coding RNA (lncRNA) Pantr2 re- sults in microcephaly in a knockout murine model of cor- ticogenesis, however, the precise mechanisms used are un- known. We […]
Kavli Affiliate: Eran Mukamel | Authors: Matthew G Heffel, Jingtian Zhou, Yi Zhang, Dong-Sung Lee, Kangcheng Hou, Oier Pastor Alonso, Kevin Abuhanna, Anthony D Schmitt, Terence Li, Maximilian Haeussler, Brittney Wick, Martin Jinye Zhang, Fangming Xie, Ryan S Ziffra, Eran A Mukamel, Eleazar Eskin, Bogdan Pasaniuc, Joseph R. Ecker, Jesse Dixon, Tomasz J. Nowakowski, Mercedes […]
Kavli Affiliate: Robert Edwards | Authors: Joel E Brame, Craig Liddicoat, Catherine A Abbott, Robert A Edwards, Jake M Robinson, Nicolas E Gauthier and Martin F Breed | Summary: Abstract Butyrate-producing bacteria are found in many ecosystems and organisms, including humans. They ferment organic matter, producing the by-product butyrate, a short-chain fatty acid with important […]
Kavli Affiliate: Sreekanth Chalasani | Authors: Amy Pribadi, Kaila Rosales, Kirthi C Reddy and Sreekanth H Chalasani | Summary: Abstract Prey respond to predators by altering their behavior to optimize their own fitness and survival. We probe the interactions between Caenorhabditis elegans and its naturally cohabiting predator Pristionchus uniformis to reveal the pathways driving changes […]
Kavli Affiliate: Bradley Voytek | Authors: Michael Preston, Natalie Schaworonkow and Bradley Voytek | Summary: Abstract Electrical recordings of human brain activity via electroencephalography (EEG) show prominent, rhythmic voltage fluctuations. These periodic oscillations have been linked to nearly every cognitive and perceptual process, as well numerous disease states. Recent methodological and theoretical advances, however, have […]
Kavli Affiliate: Fred Gage | Authors: W. Sharon Zheng, Yajun Zhang, Roger E. Zhu, Peng Zhang, Smriti Gupta, Limeng Huang, Deepika Sahoo, Kaiming Guo, Matthew E. Glover, Krishna C. Vadodaria, Mengyao Li, Tongrui Qian, Miao Jing, Jiesi Feng, Jinxia Wan, Philip M. Borden, Kaspar Podgorski, Farhan Ali, Alex C. Kwan, Li Gan, Li Lin, Fred […]
Kavli Affiliate: Stefano Fusi | Authors: Valeria Fascianelli, Fabio Stefanini, Satoshi Tsujimoto, Aldo Genovesio and Stefano Fusi | Summary: Abstract Animals likely use a variety of strategies to solve laboratory tasks. Traditionally, combined analysis of behavioral and neural recording data across subjects employing different strategies may obscure important signals and give confusing results. Hence it […]
Kavli Affiliate: Costa, Rui | Authors: Paul Botros, Nuria Vendrell-Llopis, Rui Costa and Jose Carmena | Summary: Abstract Throughout learning, refinement of cortical activity in cortex, a process termed “credit assignment”, underlies the refinement of behavioral actions leading to reward. While previous research shows striatum’s role in linking behavior to reward, striatum’s role in linking […]