Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease

Posted by klaurent Columbia

Kavli Affiliate: Wei Min | Authors: Daniel J.M. Crouch, Jamie R.J. Inshaw, Catherine C. Robertson, Jia-Yuan Zhang, Wei-Min Chen, Suna Onengut-Gumuscu, Antony J. Cutler, Carlo Sidore, Francesco Cucca, Flemming Pociot, Patrick Concannon, Steven S. Rich and John A. Todd | Summary: For polygenic traits, associations with genetic variants can be detected over many chromosome regions, […]


Continue.. Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease

An Integrated Platform for High-Throughput Nanoscopy

Posted by klaurent Yale

Kavli Affiliate: Joerg Bewersdorf | Authors: Andrew E. S. Barentine, Yu Lin, Edward M Courvan, Phylicia Kidd, Miao Liu, Leonhard Balduf, Timy Phan, Felix Rivera-Molina, Michael R. Grace, Zach Marin, Mark Lessard, Juliana Rios-Chen, Siyuan Wang, Karla M Neugebauer, Joerg Bewersdorf and David Baddeley | Summary: Diffraction-unlimited single-molecule techniques like STORM and (F)PALM enable three-dimensional […]


Continue.. An Integrated Platform for High-Throughput Nanoscopy

Glutamatergic projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in a mouse model of depression

Posted by klaurent Hopkins

Kavli Affiliate: Paul Greengard | Authors: Ana Milosevic, Lucian Medrihan, Margarete Knudsens, Tatiana Ferraro, Pedro Del Cioppo Vasques, Yevgeniy Romin, Sho Fujisawa and Paul Greengard | Summary: The cholinergic interneurons (ChATs) of the nucleus accumbens (NAc) have a critical role in the activity of this region, specifically in the context of major depressive disorder. To […]


Continue.. Glutamatergic projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in a mouse model of depression

Dysregulation of neuroproteasomes by ApoE isoforms drives endogenous Tau aggregation

Posted by klaurent UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Victoria Paradise, Malavika Sabu, Joanna Bafia, Nyle A Sharif, Chi Nguyen, Rijuta Dhanraj Mukim, Kalin D Konrad-Vicario, Xiao Wang, Bianca T Corjuc, Jack Fu, Gabriella Maldonado, Jeffrey Ndubisi, Michael Strickland, Helen Figueroa, Douglas L Almeida, Bradley T Hyman, David M Holtzman, Tal Nuriel and Kapil V Ramachandran | […]


Continue.. Dysregulation of neuroproteasomes by ApoE isoforms drives endogenous Tau aggregation

Genome-wide detection of human variants that disrupt intronic branchpoints

Posted by klaurent Rockefeller

Kavli Affiliate: Jean Laurent Casanova | Authors: Peng Zhang, Quentin Philippot, Weicheng Ren, Wei-Te Lei, Juan Li, Peter D. Stenson, Pere Soler Palacín, Roger Colobran, Bertrand Boisson, Shen-Ying Zhang, Anne Puel, Qiang Pan-Hammarström, Qian Zhang, David N. Cooper, Laurent Abel and Jean-Laurent Casanova | Summary: Pre-mRNA splicing is initiated with the recognition of a single-nucleotide […]


Continue.. Genome-wide detection of human variants that disrupt intronic branchpoints

Bayesian interpolation for power laws in neural data analysis

Posted by klaurent NTNU

Kavli Affiliate: Yasser Roudi, Ivan Davidovich | Authors: Ivan A. Davidovich and Yasser Roudi | Summary: Power laws arise in a variety of phenomena ranging from matter undergoing phase transition to the distribution of word frequencies in the English language. Usually, their presence is only apparent when data is abundant, and accurately determining their exponents […]


Continue.. Bayesian interpolation for power laws in neural data analysis

Peptidergic signaling controls the dynamics of sickness behavior in Caenorhabditis elegans

Posted by klaurent Rockefeller

Kavli Affiliate: Cori Bargmann | Authors: Javier Marquina-Solis, Elke Vandewyver, Josh Hawk, Daniel Colon-Ramos, Isabel Beets and Cori Bargmann | Summary: Pathogenic infection elicits sickness behaviors that promote recovery and survival of the host. For example, following infection with the pathogenic bacterium Pseudomonas aeruginosa PA14, the nematode Caenorhabditis elegans modifies its sensory preferences to avoid […]


Continue.. Peptidergic signaling controls the dynamics of sickness behavior in Caenorhabditis elegans

Context-dependent sensory modulation underlies Bayesian vocal sequence perception

Posted by klaurent UCSD / Salk

Kavli Affiliate: Ali Brivanlou, Eric Siggia | Authors: Anna Yoney, Lu Bai, Ali H. Brivanlou and Eric D Siggia | Summary: Vocal communication in both songbirds and humans relies on categorical perception of smoothly varying acoustic spaces. Vocal perception can be biased by expectation and context, but the mechanisms of this bias are not well […]


Continue.. Context-dependent sensory modulation underlies Bayesian vocal sequence perception

Mechanisms Underlying WNT-mediated Priming of Human Embryonic Stem Cells

Posted by klaurent Rockefeller

Kavli Affiliate: Ali Brivanlou, Eric Siggia | Authors: Anna Yoney, Lu Bai, Ali H. Brivanlou and Eric D Siggia | Summary: Embryogenesis is guided by a limited set of signaling pathways dynamically expressed in different places. How a context dependent signaling response is generated has been a central question of developmental biology, which can now […]


Continue.. Mechanisms Underlying WNT-mediated Priming of Human Embryonic Stem Cells

Shell Microelectrode Arrays (MEAs) for brain organoids

Posted by klaurent Hopkins

Kavli Affiliate: Brian Caffo | Authors: Qi Huang, Bohao Tang, July Carolina Romero, Yuqian Yang, Saifeldeen Khalil Elsayed, Gayatri Pahapale, Tien-Jung Lee, Itzy Erin Morales Pantoja, Fang Han, Cynthia Berlinicke, Terry Xiang, Mallory Solazzo, Thomas Hartung, Zhao Qin, Brian Caffo, Lena Smirnova and David H Gracias | Summary: Brain organoids are important models for mimicking […]


Continue.. Shell Microelectrode Arrays (MEAs) for brain organoids