TMEM106B is increased in Multiple Sclerosis plaques, and deletion causes accumulation of lipid after demyelination

Posted by klaurent Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C DuBois, John R Corboy, Stephen M. Strittmatter, Hillary Guzik, Sarah Graff and Rashed M Nagra | Summary: During inflammatory, demyelinating diseases such as multiple sclerosis (MS) axonal damage is prevalent early in the disease course. Axonal damage includes swellings, defects […]


Continue.. TMEM106B is increased in Multiple Sclerosis plaques, and deletion causes accumulation of lipid after demyelination

Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

Posted by klaurent Hopkins

Kavli Affiliate: Peter Searson | Authors: Raleigh M. Linville, Matthew B. Sklar, Gabrielle N. Grifno, Renee F. Nerenberg, Justin Zhou, Robert Ye, Jackson G. DeStefano, Zhaobin Guo, Ria Jha, John J. Jamieson, Nan Zhao and Peter C. Searson | Summary: The blood-brain barrier (BBB) plays a pivotal role in brain health and disease. In the […]


Continue.. Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

A neural mechanism for terminating decisions

Posted by klaurent Columbia

Kavli Affiliate: Michael Shadlen | Authors: Gabriel M Stine, Eric M Trautmann, Danique Jeurissen and Michael N Shadlen | Summary: The brain makes decisions by accumulating evidence until there is enough to stop and choose. Neural mechanisms of evidence accumulation are well established in association cortex, but the site and mechanism of termination is unknown. […]


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Minute-scale oscillatory sequences in medial entorhinal cortex

Posted by klaurent NTNU

Kavli Affiliate: Edvard Moser, May Britt Moser, Ragnhild Leifsdottir, Horst Obenhaus | Authors: Soledad Gonzalo Cogno, Horst A. Obenhaus, Ragnhild Irene Jacobsen, Flavio Donato, May-Britt Moser and Edvard I. Moser | Summary: The medial entorhinal cortex (MEC) hosts many of the brain’s circuit elements for spatial navigation and episodic memory, operations that require neural activity […]


Continue.. Minute-scale oscillatory sequences in medial entorhinal cortex

A Spectrum of Time Horizons for Dopamine Signals

Posted by klaurent UCSF

Kavli Affiliate: Joshua Berke | Authors: Wei Wei, Ali Mohebi and Joshua Berke | Summary: Dopamine input to striatum can encode reward prediction error, a critical signal for updating predictions of future rewards. However, it is unclear how this mechanism handles the need to make predictions, and provide feedback, over multiple time horizons: from seconds […]


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The swan genome and transcriptome: its not all black and white

Posted by klaurent Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Anjana C. Karawita, Yuanyuan Cheng, Keng Yih Chew, Arjun Challgula, Robert Kraus, Ralf C. Mueller, Marcus Z. W. Tong, Katina D. Hulme, Helle Beielefeldt-Ohmann, Lauren E. Steele, Melanie Wu, Julian DJ Sng, Ellesandra Noye, Timothy J. Bruxner, Gough G. Au, Suzanne Lowthe, Julie Blommaert, Alexander Suh, Alexander J. McCauley, […]


Continue.. The swan genome and transcriptome: its not all black and white

Repeated birth injuries lead to pelvic floor muscle dysfunction and impairment in regeneration

Posted by klaurent UCSD / Salk

Kavli Affiliate: Karen Christman | Authors: Pamela Duran, Emma Zelus, Saya French, Lindsey Burnett, Karen Christman and Marianna Alperin | Summary: Objectives: Childbirth is a key risk factor for pelvic floor muscle (PFM) injury and dysfunction, and subsequent pelvic floor disorders (PFDs). Multiparity further exacerbates these risks. Using the pre-clinical rat model of simulated birth […]


Continue.. Repeated birth injuries lead to pelvic floor muscle dysfunction and impairment in regeneration

The lateral habenula mediates the association of a conditioned stimulus with the absence of an appetitive unconditioned stimulus

Posted by klaurent Hopkins

Kavli Affiliate: Michela Gallagher | Authors: Dong-Hee Kim, In-Beom Jin, Nam-Heon Kim, Yong-Jae Jeon, Bo-Ryoung Choi, Michela Gallagher and Jung-Soo Han | Summary: The lateral habenula (LHb) has been implicated in conditioned inhibition. Here, the modulating effects of LHb activity on the association of a conditioned stimulus (CS) with the nonoccurrence of an unconditioned stimulus […]


Continue.. The lateral habenula mediates the association of a conditioned stimulus with the absence of an appetitive unconditioned stimulus

High precision magnetoencephalography reveals increased right-inferior frontal gyrus beta power during response conflict

Posted by klaurent UCSD / Salk

Kavli Affiliate: Adam Aron | Authors: Pria L Daniel, James J Bonaiuto, Sven Bestmann, Adam R Aron and Simon Little | Summary: Flexibility of behavior and the ability to rapidly switch actions is critical for adaptive living in humans. It is well established that the right-inferior frontal gyrus (R-IFG) is recruited during outright action-stopping, relating […]


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Altered basal ganglia output during self-restraint

Posted by klaurent UCSD / Salk

Kavli Affiliate: Joshua Berke | Authors: Bon-Mi Gu and Joshua D. Berke | Summary: Suppressing actions is essential for flexible behavior. Multiple neural circuits involved in behavioral inhibition converge upon a key basal ganglia output nucleus, the substantia nigra pars reticulata (SNr). To examine how changes in basal ganglia output contribute to self-restraint, we recorded […]


Continue.. Altered basal ganglia output during self-restraint