Serine Racemase is a Cysteine Racemase and Physiologic Down Regulator of Insulin Promoter Methylation

Posted by klaurent Hopkins

Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Moataz M Gadalla, Lauren Albacarys, Timothy West, Harry Saavedra, Leon Mario Amzel and Solomon H. Snyder | Summary: Endogenous D-stereoisomers are being recognized as functionally important molecules in mammals. Here we report the first identification of endogenous D-cysteine in mammalian pancreas. Serine Racemase (SR) is the biosynthetic […]


Continue.. Serine Racemase is a Cysteine Racemase and Physiologic Down Regulator of Insulin Promoter Methylation

Clonally selected lines after CRISPR/Cas editing are not isogenic

Posted by klaurent Yale

Kavli Affiliate: Robert Edwards | Authors: Michael J. Roach, Sarah Beecroft, Kathie Mihindukulasuriya, Leran Wang, Lais Farias Oliveira Lima, Elizabeth A. Dinsdale, Robert Edwards and Scott Allyn Handley | Summary: The CRISPR-Cas9 system has enabled researchers to precisely modify/edit the sequence of a genome. A typical editing experiment consists of two steps: (i) editing cultured […]


Continue.. Clonally selected lines after CRISPR/Cas editing are not isogenic

Hecatomb: An End-to-End Research Platform for Viral Metagenomics

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Michael J. Roach, Sarah Beecroft, Kathie Mihindukulasuriya, Leran Wang, Lais Farias Oliveira Lima, Elizabeth A. Dinsdale, Robert Edwards and Scott Allyn Handley | Summary: Analysis of viral diversity using modern nucleic acid sequencing technologies presents several unique challenges. Foremost being that virus detection requires a non-targeted, random (shotgun) approach. […]


Continue.. Hecatomb: An End-to-End Research Platform for Viral Metagenomics

Flexible perceptual encoding by discrete gamma events

Posted by klaurent Yale

Kavli Affiliate: Jessica Cardin | Authors: Quentin Perrenoud, Antonio H. de O. Fonseca, Austin Airhart, James Bonanno, Rong Mao and Jessica A Cardin | Summary: Although behaviorally relevant patterns of neocortical activity in specific frequency bands have been broadly characterized, identifying individual underlying network events remains a key challenge in understanding information processing in cortical […]


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Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate

Posted by klaurent UCSF

Kavli Affiliate: Kira Poskanzer | Authors: Kira Poskanzer, Trisha V Vaidyanathan, Vincent Tse and Esther M Lim | Summary: Astrocytes perform critical functions in the nervous system, many of which are dependent on neurotransmitter-sensing through G protein-coupled receptors (GPCRs). However, whether specific astrocytic outputs follow specific GPCR activity remains unclear, and exploring this question is […]


Continue.. Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

Posted by klaurent UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Meghana Pagadala, Victoria H. Wu, Eva Perez-Guijarro, Hyo Kim, Andrea Castro, James Talwar, Timothy Sears, Cristian Gonzalez-Colin, Steven Cao, Benjamin Schmiedel, Shervin Goudarzi, Divya Kirani, Rany Salem, Gerald Morris, Olivier Harismendy, Sandip Pravin Patel, Jill P. Mesirov, Maurizio Zanetti, Chi-Ping Day, Chun Chieh Fan, Wesley K. Thompson, Glenn Merlino, […]


Continue.. Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

Posted by klaurent UCSD / Salk

Kavli Affiliate: Fred Gage | Authors: Shani Stern, Lei Zhang, Meiyan Wang, Rebecca Wright, Diogo Cordeiro, David Peles, Yuqing Hang, Ana P Mendes, Tithi Baul, Julien Roth, Shashank Coorapati, Marco Boks, Hilleke Hulshoff Pol, Kristen J. Brennand, Janos M Rethelyi, Rene S. Kahn, Maria C. Marchetto and Fred H. Gage | Summary: Schizophrenia affects approximately […]


Continue.. Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

Transretinal migration of astrocytes and brain/spinal cord-like cells arising from transplanted human retinal organoids.

Posted by klaurent Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Ying Liu, Clayton Santiago, Akin Sogunro, Gregory K. Konar, Ming-Wen Hu, Minda M. McNally, Yuchen Lu, Zhuolin Li, Dzhalal Agakishiev, Sarah Hadyniak, Katarzyna Hussey, Tyler J. Creamer, Linda D. Orzolek, Derek Teng, Jiang Qian, Zheng Jiang, Robert J. Johnston, Jr., Seth Blackshaw and Mandeep S. Singh | Summary: Human […]


Continue.. Transretinal migration of astrocytes and brain/spinal cord-like cells arising from transplanted human retinal organoids.

Abstract representations emerge naturally in neural networks trained to perform multiple tasks

Posted by klaurent Columbia

Kavli Affiliate: Stefano Fusi | Authors: W. Jeffrey Johnston and Stefano Fusi | Summary: Humans and other animals demonstrate a remarkable ability to generalize knowledge across distinct contexts and objects during natural behavior. We posit that this ability to generalize arises from a specific representational geometry, that we call abstract and that is referred to […]


Continue.. Abstract representations emerge naturally in neural networks trained to perform multiple tasks

BigNeuron: A resource to benchmark and predict best-performing algorithms for automated reconstruction of neuronal morphology

Posted by klaurent UCSD / Salk

Kavli Affiliate: Ann Shyn Chiang, Kristofer Bouchard | Authors: Linus Manubens-Gil, Zhi Zhou, Hanbo Chen, Arvind Ramanathan, Xiaoxiao Liu, Yufeng Liu, Alessandro Bria, Todd Gillette, Zongcai Ruan, Jian Yang, Miroslav Radojević, Ting Zhao, Li Cheng, Lei Qu, Siqi Liu, Kristofer E. Bouchard, Lin Gu, Weidong Cai, Shuiwang Ji, Badrinath Roysam, Ching-Wei Wang, Hongchuan Yu, Amos […]


Continue.. BigNeuron: A resource to benchmark and predict best-performing algorithms for automated reconstruction of neuronal morphology