Guided construction of single cell reference for human and mouse lung

Kavli Affiliate: Jin Kang | Authors: Minzhe Guo, Michael P. Morley, Yixin Wu, Yina Du, Shuyang Zhao, Andrew Wagner, Michal Kouril, Kang Jin, Nathan Gaddis, Joseph A. Kitzmiller, Kathleen Stewart, Maria C. Basil, Susan M. Lin, Yun Ying, Apoorva Babu, Kathryn A. Wikenheiser-Brokamp, Kyu Shik Mun, Anjaparavanda P. Naren, Sara Lin, Geremy Clair, Joshua N. […]


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Neural learning rules for generating flexible predictions and computing the successor representation

Kavli Affiliate: Larry Abbott | Authors: Ching Fang, Dmitriy Aronov, Larry F Abbott and Emily Mackevicius | Summary: The predictive nature of the hippocampus is thought to be useful for memory-guided cognitive behaviors. Inspired by the reinforcement learning literature, this notion has been formalized as a predictive map called the successor representation (SR). The SR […]


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Interactive Neurorobotics: Behavioral and Neural Dynamics of Agent Interactions

Kavli Affiliate: Andrea Chiba | Authors: Eric J Leonardis, Leo Breston, Rhiannon Lucero-Moore, Leigh Sena, Raunit Kohli, Luisa Schuster, Lacha Barton-Gluzman, Laleh K Quinn, Janet Wiles and Andrea Chiba | Summary: Interactive neurorobotics is a subfield which characterizes brain responses evoked during interaction with a robot, and their relationship with the behavioral responses. Gathering rich […]


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Immunomodulatory Extracellular Matrix Hydrogel Mitigates Scar Formation in a Model of Tongue Fibrosis.

Kavli Affiliate: Karen Christman | Authors: mma I Zelus, Aaron Panduro, Marianna Alperin, Andrew M Vahabzadeh-Hagh and Karen L Christman | Summary: Background: While head and neck cancer treatment regimens, including surgical resection, irradiation, and chemotherapy, are effective at removing tumors, they lead to muscle atrophy, denervation, and fibrosis, contributing to the pathogenesis of tongue […]


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Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death during Mammary Gland Involution

Kavli Affiliate: Shawn Ferguson | Authors: Jaekwang Jeong, Jongwon Lee, Gabriel Talaia, Wonnam Kim, Junho Song, Kwangmin Yoo, David G. Gonzalez, Diana Athonvarangkul, Jaehun Shin, Pamela Dann, Ann M Haberman, Lark Kyun Kim, Shawn M. Ferguson, Jungmin Choi and John Wysolmerski | Summary: Involution of the mammary gland after lactation is a dramatic example of […]


Continue.. Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death during Mammary Gland Involution

Serine Racemase is a Cysteine Racemase and Physiologic Down Regulator of Insulin Promoter Methylation

Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Moataz M Gadalla, Lauren Albacarys, Timothy West, Harry Saavedra, Leon Mario Amzel and Solomon H. Snyder | Summary: Endogenous D-stereoisomers are being recognized as functionally important molecules in mammals. Here we report the first identification of endogenous D-cysteine in mammalian pancreas. Serine Racemase (SR) is the biosynthetic […]


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Clonally selected lines after CRISPR/Cas editing are not isogenic

Kavli Affiliate: Robert Edwards | Authors: Michael J. Roach, Sarah Beecroft, Kathie Mihindukulasuriya, Leran Wang, Lais Farias Oliveira Lima, Elizabeth A. Dinsdale, Robert Edwards and Scott Allyn Handley | Summary: The CRISPR-Cas9 system has enabled researchers to precisely modify/edit the sequence of a genome. A typical editing experiment consists of two steps: (i) editing cultured […]


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Hecatomb: An End-to-End Research Platform for Viral Metagenomics

Kavli Affiliate: Robert Edwards | Authors: Michael J. Roach, Sarah Beecroft, Kathie Mihindukulasuriya, Leran Wang, Lais Farias Oliveira Lima, Elizabeth A. Dinsdale, Robert Edwards and Scott Allyn Handley | Summary: Analysis of viral diversity using modern nucleic acid sequencing technologies presents several unique challenges. Foremost being that virus detection requires a non-targeted, random (shotgun) approach. […]


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Flexible perceptual encoding by discrete gamma events

Kavli Affiliate: Jessica Cardin | Authors: Quentin Perrenoud, Antonio H. de O. Fonseca, Austin Airhart, James Bonanno, Rong Mao and Jessica A Cardin | Summary: Although behaviorally relevant patterns of neocortical activity in specific frequency bands have been broadly characterized, identifying individual underlying network events remains a key challenge in understanding information processing in cortical […]


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Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate

Kavli Affiliate: Kira Poskanzer | Authors: Kira Poskanzer, Trisha V Vaidyanathan, Vincent Tse and Esther M Lim | Summary: Astrocytes perform critical functions in the nervous system, many of which are dependent on neurotransmitter-sensing through G protein-coupled receptors (GPCRs). However, whether specific astrocytic outputs follow specific GPCR activity remains unclear, and exploring this question is […]


Continue.. Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate