Machine-learning dissection of Human Accelerated Regions in primate neurodevelopment

Posted by klaurent UCSF

Kavli Affiliate: Arnold Kriegstein, Alex Pollen | Authors: Sean Whalen, Fumitaka Inoue, Hane Ryu, Tyler Fair, Eirene Markenscoff-Papadimitriou, Kathleen Keough, Martin Kircher, Beth Martin, Beatriz Alvarado, Orry Elor, Dianne Laboy Cintron, Alex Williams, Md. Abul Hassan Samee, Sean Thomas, Robert Krencik, Erik Ullian, Arnold Kriegstein, Jay Shendure, Alex Pollen, Nadav Ahituv and Katherine Pollard | […]


Continue.. Machine-learning dissection of Human Accelerated Regions in primate neurodevelopment

The role of the cerebellum in learning to predict reward: evidence from cerebellar ataxia

Posted by klaurent Columbia

Kavli Affiliate: Daphna Shohamy | Authors: Jonathan Nicholas, Christian Amlang, Chi-Ying Lin, Leila Montaser-Kouhsari, Natasha Desai, Ming-Kai Pan, Sheng-Han Kuo and Daphna Shohamy | Summary: Recent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to […]


Continue.. The role of the cerebellum in learning to predict reward: evidence from cerebellar ataxia

Prioritizing virtual screening with interpretable interaction fingerprints

Posted by klaurent UCSF

Kavli Affiliate: Michael Keiser | Authors: Alexandre V Fassio, Laura Shub, Luca Ponzoni, Jessica McKinley, Matthew J O’Meara, Rafaela S Ferreira, Michael J Keiser and Raquel C de Melo Minardi | Summary: Machine learning-based drug discovery success depends on molecular representation. Yet traditional molecular fingerprints omit both the protein and pointers back to structural information […]


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A developmental pathway for epithelial-to-motoneuron transformation in C. elegans

Posted by klaurent Rockefeller

Kavli Affiliate: Shai Shaham | Authors: Alina Rashid, Maya Tevlin, Yun Lu and Shai Shaham | Summary: Motoneurons and motoneuron-like pancreatic beta cells arise from radial glia and ductal cells, both tube-lining progenitors that share molecular regulators. To uncover programs underlying motoneuron formation, we studied a similar, cell-division-independent transformation of the C. elegans tube-lining Y […]


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Unifying model for three forms of contextual modulation including feedback input from higher visual areas

Posted by klaurent Columbia

Kavli Affiliate: Kenneth Miller | Authors: Serena Di santo, Mario Dipoppa, Andreas Keller, Morgane Roth, Massimo Scanziani and Kenneth D Miller | Summary: Neural responses to a localized visual stimulus are modulated by the content of its surrounding. This phenomenon manifests in several forms of contextual modulation, including three interrelated properties of the visual cortex: […]


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The transcription regulator Lmo3 is required for cell fate specification in the external globus pallidus

Posted by klaurent UCSF

Kavli Affiliate: John Rubenstein | Authors: Shiona Biswas, C. Savio Chan, John L.R. Rubenstein and Lin Gan | Summary: The external globus pallidus (Gpe) is an essential component of the basal ganglia, a group of subcortical nuclei that are involved in control of action. Changes in the firing of GPe neurons are associated with both […]


Continue.. The transcription regulator Lmo3 is required for cell fate specification in the external globus pallidus

Physical resilience in the brain: The effect of white matter disease on brain networks in cognitively normal older adults

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller | Authors: Blake R Neyland, Samuel N Lockhart, Robert G Lyday, Laura D Baker, Elizabeth P Handing, Michael E Miller, Stephen B Kritchevsky, Paul J Laurienti and Christina E Hugenschmidt | Summary: BACKGROUND: Physical resilience with age is considered a key feature of healthy aging, but current understanding of the neural […]


Continue.. Physical resilience in the brain: The effect of white matter disease on brain networks in cognitively normal older adults

Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility

Posted by klaurent UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: James Talwar, David Laub, Meghana Pagadala, Andrea Castro, McKenna Lewis, Georg E. Luebeck, Bryan Gorman, Cuiping Pan, Frederick N. Dong, Kyriacos Markianos, Richard Hauger, Saiju Pyarajan, Philip S. Tsao, Gerald P. Morris, Rany M. Salem, Wesley K. Thompson, Kit Curtius, Maurizio Zanetti and Hannah Carter | Summary: Autoimmunity and […]


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Hippocampus as a generative circuit for predictive coding of future sequences

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Yusi Chen, Huanqiu Zhang and Terrence J Sejnowski | Summary: The interaction between hippocampus and cortex is key to memory formation and representation learning. Based on anatomical wiring and transmission delays, we proposed a self-supervised recurrent neural network (PredRAE) with a predictive reconstruction loss to account for the cognitive […]


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Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes

Posted by klaurent Hopkins

Kavli Affiliate: Carey Priebe, Joshua Vogelstein | Authors: Benjamin D Pedigo, Michael Winding, Carey E Priebe and Joshua T Vogelstein | Summary: Graph matching algorithms attempt to find the best correspondence between the nodes of two networks. These techniques have previously been used to match individual neurons in nanoscale connectomes – in particular, to find […]


Continue.. Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes