Dissecting neural computations of the human auditory pathway using deep neural networks for speech

Posted by klaurent UCSF

Kavli Affiliate: Edward Chang | Authors: Yuanning Li, Gopala K Anumanchipalli, Abdelrahman Mohamed, Junfeng Lu, Jinsong Wu and Edward F Chang | Summary: The human auditory system extracts rich linguistic abstractions from the speech signal. Traditional approaches to understand this complex process have used classical linear feature encoding models, with limited success. Artificial neural networks […]


Continue.. Dissecting neural computations of the human auditory pathway using deep neural networks for speech

IReNA: integrated regulatory network analysis of single-cell transcriptomes

Posted by klaurent Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Cjunyao jiang, Pin Lyu, Jinlian Li, Sunan Huang, Seth Blackshaw, Jiang Qian and Jie Wang | Summary: Although single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase accessible chromatin using sequencing (scATAC-seq) have been widely used, few methods can reliably integrate these data to perform regulatory network analysis. Here, […]


Continue.. IReNA: integrated regulatory network analysis of single-cell transcriptomes

FEMA: Fast and efficient mixed-effects algorithm for population-scale whole brain imaging data

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terry Jernigan, Anders Dale, Wesley Thompson | Authors: Chun Chieh Fan, Clare E Palmer, John Iverson, Diliana Pecheva, Oleksandr Frei, Dominic Holland, Wesley K Thompson, Donald Hagler, Terry L Jernigan, Ole Andreassen, Anders M. Dale and Thomas Nichols | Summary: The linear mixed effects model (LME) is a versatile modeling approach to deal […]


Continue.. FEMA: Fast and efficient mixed-effects algorithm for population-scale whole brain imaging data

Cohesin erases genomic-proximity biases to drive stochastic Protocadherin expression for proper neural wiring

Posted by klaurent UCSF

Kavli Affiliate: Daniele Canzio | Authors: Lea Kiefer, Gabrielle Isabelle F. Servito, Sandy M Rajkumar, Jennifer Langen, Anna Chiosso, Alexander Buckley, Elizabeth S. Cha, Adan Horta, Michael H Mui and Daniele Canzio | Summary: Clustered Protocadherin (Pcdh) proteins act as cell-surface recognition barcodes for neural circuit formation. Neurites expressing the same barcode repel each other, […]


Continue.. Cohesin erases genomic-proximity biases to drive stochastic Protocadherin expression for proper neural wiring

MOSAIC: A Unified Trait Database to Complement Structured Population Models

Posted by klaurent UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Connor Bernard, Gabriel Silva Santos, Jacques Deere, Roberto Rodriguez-Caro, Pol Capdevila, Erik Kusch, Samuel Gascoigne, John Jackson and Roberto Salguero-Gomez | Summary: The ecological sciences have joined the big data revolution. However, despite exponential growth in data availability, broader interoperability amongst datasets is still needed to unlock the potential […]


Continue.. MOSAIC: A Unified Trait Database to Complement Structured Population Models

Not optimal, just noisy: the geometry of correlated variability leads to highly suboptimal sensory coding

Posted by klaurent UCSF

Kavli Affiliate: Kristofer Bouchard | Authors: Jesse A Livezey, Pratik Singh Sachdeva, Maximilian E Dougherty, Mathew T Summers and Kristofer E Bouchard | Summary: The brain represents the world through the activity of neural populations. Correlated variability across simultaneously recorded neurons (noise correlations) has been observed across cortical areas and experimental paradigms. Many studies have […]


Continue.. Not optimal, just noisy: the geometry of correlated variability leads to highly suboptimal sensory coding

In situ architecture of the lipid transport protein VPS13C at ER-lysosomes membrane contacts

Posted by klaurent Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Shujun Cai, Yumei Wu, Andres Guillen-Samander, William F Hancock-Cerutti, Jun Liu and Pietro De Camilli | Summary: VPS13 is a eukaryotic lipid transport protein localized at membrane contact sites. Previous studies suggested that it may transfer lipids between adjacent bilayers by a bridge-like mechanism. Direct evidence for this hypothesis […]


Continue.. In situ architecture of the lipid transport protein VPS13C at ER-lysosomes membrane contacts

Enzyme-Responsive Nanoparticles for the Targeted Delivery of an MMP Inhibitor to the Heart post Myocardial Infarction

Posted by klaurent UCSD / Salk

Kavli Affiliate: Karen Christman | Authors: Holly Sullivan, Yifei Liang, Kendra Worthington, Colin Luo, Nathan C Gianneschi and Karen Christman | Summary: In this paper, we describe block copolymer amphiphiles consisting of a hydrophilic matrix metalloproteinase (MMP) peptide substrate, and a hydrophobic small molecule MMP inhibitor PD166793 for the treatment of acute myocardial infarction. These […]


Continue.. Enzyme-Responsive Nanoparticles for the Targeted Delivery of an MMP Inhibitor to the Heart post Myocardial Infarction

Automated assembly of high-quality diploid human reference genomes

Posted by klaurent Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Erich D. Jarvis, Giulio Formenti, Arang Rhie, Andrea Guarracino, Chentao Yang, Jonathan Wood, Alan Tracey, Francoise Thibaud-Nissen, Mitchell R Vollger, David Porubsky, Haoyu Cheng, Mobin Asri, Glennis A Logsdon, Paolo Carnevali, Mark Chaisson, Chen-Shan Chin, Sarah Cody, Joanna Collins, Peter Ebert, Merly Escalona, Olivier Fedrigo, Robert S Fulton, Lucinda […]


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Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson’s Disease: Predictions and Validation of a Patient-Specific Non-Linear Model

Posted by klaurent UCSF

Kavli Affiliate: Philip Starr | Authors: James J. Sermon, Maria Olaru, Juan Anso, Simon Little, Rafal Bogacz, Philip A. Starr, Timothy Denison and Benoit Duchet | Summary: Background Entrainment of brain oscillations has been hypothesised as a potential mechanism of neuromodulation. While neuromodulation has been shown to be an effective therapy for a variety of […]


Continue.. Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson’s Disease: Predictions and Validation of a Patient-Specific Non-Linear Model