Kavli Affiliate: Loyal Goff | Authors: Shijie C. Zheng, Genevieve Stein-O’Brien, Leandros Boukas, Loyal A Goff and Kasper D Hansen | Summary: RNA velocity analysis of single cells promises to predict temporal dynamics from gene expression. Indeed, in many systems, it has been observed that RNA velocity produces a vector field which qualitatively reflects known […]
Kavli Affiliate: Michael Brainard | Authors: Lucas Y Tian, Timothy L Warren and Michael S Brainard | Summary: Complex behaviors depend on the coordinated activity of neural ensembles in interconnected brain areas. The behavioral function of such coordination, often measured as co-fluctuations in neural activity across areas, is poorly understood. One hypothesis is that rapidly […]
Kavli Affiliate: Nicholas Spitzer | Authors: Marta Pratelli, Arth Thaker, Huiquan Li, Swetha Godavarthi and Nicholas C. Spitzer | Summary: Decreased cognitive ability is a major consequence of exposure to drugs of abuse, but the underlying neuroplastic changes have been elusive. We show that both phencyclidine and methamphetamine cause a population of prelimbic pyramidal neurons […]
Kavli Affiliate: Fred Gage | Authors: Madison Wilson, Martin Thunemann, Xin Liu, Yichen Lu, Francesca Puppo, Jason Adams, Jeong-Hoon Kim, Donald Pizzo, Srdjan Djurovic, Ole Andreassen, Abed Mansour, Fred H. Gage, Alysson R Muotri, Anna Devor and Duygu Kuzum | Summary: Human cortical organoids, three-dimensional neuronal cell cultures derived from human induced pluripotent stem cells, […]
Kavli Affiliate: Patrick Kanold | Authors: Binghan Xue, Joseph P-Y Kao and Patrick O Kanold | Summary: A common impairment in aging is age-related hearing loss (presbycusis), which manifests as impaired spectrotemporal processing. Aging is accompanied by alteration in normal inhibitory (GABA) neurotransmission and changes in excitatory (NMDA and AMPA) synapses in the auditory cortex […]
Kavli Affiliate: Simon Ball | Authors: Luke T Slater, John A Williams, Paul N Schofield, Sophie Russell, Samantha C Pendleton, Andreas Karwath, Hilary Fanning, Simon Ball, Robert T Hoehndorf and Georgios V Gkoutos | Summary: Abstract Background Annotation of biomedical entities with ontology terms facilitates the use of background knowledge in analysis. Described entities may […]
Kavli Affiliate: Pietro DeCamilli | Authors: Daehun Park, Yumei Wu, Aaron Baublis and Pietro De Camilli | Summary: Ectopic expression in fibroblasts of synapsin 1 and synaptophysin is sufficient to generate condensates of vesicles highly reminiscent of synaptic vesicle (SV) clusters and with liquid-like properties. We show that unlike synaptophysin, other major integral SV membrane […]
Kavli Affiliate: James Knierim | Authors: Manu S Madhav, Ravikrishnan P Jayakumar, Brian Y Li, Francesco Savelli, James J Knierim and Noah J Cowan | Summary: Understanding the interplay between sensory input, endogenous neural dynamics, and behavioral output is key toward understanding the principles of neural computation. Hippocampal place cells are an ideal system to […]
Kavli Affiliate: Michael Crair | Authors: David O’Connor, Francesca Mandino, Xilin Shen, Corey Horien, Xinxin Ge, Peter Herman, Michael Crair, Xenophon Papademetris, Evelyn MR Lake and Robert Todd Constable | Summary: To improve bench-to-bedside translation, it is integral that knowledge flow bidirectionally from – animal models to humans, and vice versa. This will be facilitated […]
Kavli Affiliate:Allan Basbaum | Authors: Isha Singh, Anubha Seth, Christian B. Billesbolle, Joao Braz, Ramona M. Rodriguiz, Kasturi Roy, Bethlehem Bekele, Veronica Craik, Xi-Ping Huang, Danila Boytsov, Parnian Lak, Henry R O’Donnell, Walter R Sandtner, Bryan L. Roth, Allan Basbaum, William C Wetsel, Aashish Manglik, Brian K. Shoichet and Gary Rudnick | Summary: The serotonin […]