High-resolution magic angle spinning NMR of KcsA in liposomes: the highly mobile C-terminus

Kavli Affiliate: Ann McDermott | Authors: Ann E McDermott and Gary Stanley Howarth II | Summary: The structure of the transmembrane domain of bacterial potassium channel KcsA has been extensively characterized, yet little information is available on the structure of its cytosolic N- and C-termini. This study presents high-resolution magic angle spinning (HR-MAS) and fractional […]


Continue.. High-resolution magic angle spinning NMR of KcsA in liposomes: the highly mobile C-terminus

Quantitative prediction and measurement of Piezo’s membrane footprint

Kavli Affiliate: Roderick MacKinnon | Authors: Christoph A. Haselwandter, Roderick MacKinnon, Yusong Guo and Ziao Fu | Summary: Piezo proteins are mechanosensitive ion channels that can locally curve the membrane into a dome shape (Y. R. Guo, R. MacKinnon, 2017). The curved shape of the Piezo dome is expected to deform the surrounding lipid bilayer […]


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Differential sensory and immune gene evolution in sea turtles with contrasting demographic and life histories

Kavli Affiliate: Erich Jarvis | Authors: Blair P Bentley, Tomás Carrasco-Valenzuela, Elisa K. S. Ramos, Harvinder Pawar, Larissa Souza Arantes, Alana Alexander, Shreya M Banerjee, Patrick Masterson, Martin Kuhlwilm, Martin Pippel, Jacquelyn Mountcastle, Bettina Haase, Marcela Uliano Silva, Giulio Formenti, Kerstin Howe, William Chow, Alan Tracey, Yumi Sims, Sarah Pelan, Jonathan Wood, Kelsey Yetsko, Justin […]


Continue.. Differential sensory and immune gene evolution in sea turtles with contrasting demographic and life histories

Global worming: massive invasion of North America by earthworms revealed

Kavli Affiliate: John Reynolds | Authors: Jerome Mathieu, John Warren Reynolds, Carlos Fragoso and Elizabeth Hadly | Summary: Human activities cause major ecological changes by reshuffling the spatial distribution of species. The extent to which this process affects belowground biota is a critical issue because soil organisms play a key role in ecosystem functioning and […]


Continue.. Global worming: massive invasion of North America by earthworms revealed

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

Kavli Affiliate: Robert Edwards | Authors: Sai Luo, Jun Zhang, Alex J.B. Kreutzberger, Amanda Eaton, Robert J. Edwards, Changbin Jing, Hai-Qiang Dai, Gregory D. Sempowski, Kenneth Cronin, Robert Parks, Adam Yongxin Ye, Katayoun Mansouri, Maggie Barr, Novalia Pishesha, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Anand Saminathan, Hanqin Peng, Himanshu Batra, Lorenza Bellusci, Surender Khurana, S. […]


Continue.. Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

Pumping the brakes on RNA velocity – understanding and interpreting RNA velocity estimates

Kavli Affiliate: Loyal Goff | Authors: Shijie C. Zheng, Genevieve Stein-O’Brien, Leandros Boukas, Loyal A Goff and Kasper D Hansen | Summary: RNA velocity analysis of single cells promises to predict temporal dynamics from gene expression. Indeed, in many systems, it has been observed that RNA velocity produces a vector field that qualitatively reflects known […]


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Targeted cortical stimulation reveals principles of cortical contextual interactions

Kavli Affiliate: Kenneth Miller | Authors: Shen Wang, Agostina Palmigiano, Kenneth D Miller and Stephen David Van Hooser | Summary: Cross-orientation suppression is a classic form of contextual normalization in visual cortex, yet the degree to which cortical circuits participate in the normalization computation is unclear. We visualized orientation maps of individual ferrets, and provided […]


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Cortical ripples during NREM sleep and waking in humans

Kavli Affiliate: Eric Halgren | Authors: Charles W Dickey, Ilya A Verzhbinsky, Xi Jiang, Burke Q Rosen, Sophie Kajfez, Emad N Eskandar, Jorge Gonzalez-Martinez, Sydney S Cash and Eric Halgren | Summary: Hippocampal ripples index the reconstruction of spatiotemporal neuronal firing patterns essential for the consolidation of memories in the cortex during non-rapid eye movement […]


Continue.. Cortical ripples during NREM sleep and waking in humans

Amygdalar and ERC Rostral Atrophy and Tau Pathology Reconstruction in Preclinical Alzheimer’s Disease

Kavli Affiliate: Menno Witter, Susumu Mori, Michael Miller | Authors: Kaitlin Stouffer, Claire Chen, Sue Kulason, Eileen Xu, Menno Witter, Can Ceritoglu, Marilyn Albert, Susumu Mori, Juan Troncoso, Daniel Jacob Tward and Michael I Miller | Summary: Previous research has emphasized the unique impact of Alzheimer’s Disease (AD) pathology on the medial temporal lobe (MTL), […]


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A Generalized Reinforcement Learning-Based Deep Neural Network (GRL-DNN) Agent Model for Diverse Cognitive Constructs

Kavli Affiliate: Jyoti Mishra | Authors: Sandeep Sathyanandan Nair, Vignayanandam Ravindernath Muddapu, Vigneswaran C, Pragathi Priyadharsini Balasubramani, Jyoti Mishra, Dhaskshin S Ramanathan and V Srinivasa Chakravarthy | Summary: Human cognition is characterized by a wide range of capabilities including goal-oriented selective attention, distractor suppression, decision making, response inhibition, and working memory. Much research has focused […]


Continue.. A Generalized Reinforcement Learning-Based Deep Neural Network (GRL-DNN) Agent Model for Diverse Cognitive Constructs