MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Posted by klaurent Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Em P Harrington, Riley B Catenacci, Matthew D Smith, Dongeun Heo, Cecilia E Miller, Keya R Meyers, Jenna Glatzer, Dwight E Bergles and Peter A Calabresi | Summary: Abstract Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown […]


Continue.. MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Feasibility Analyses and Experimental Confirmation of Dove Prism Based Dual-fiberscope Rotary Joint

Posted by klaurent Hopkins

Kavli Affiliate: Xingde Li | Authors: Yuehan Liu, Hyeon-Cheol Park, Haolin Zhang and Xingde Li | Summary: Abstract Two-photon fluorescence microscopy has enjoyed its wide adoption in neuroscience. Head-mounted miniaturized fiberscopes offered an exciting opportunity for enabling neural imaging in freely-behaving animals with high 3D resolution. Here we propose a dual-fiberscope rotary joint based on […]


Continue.. Feasibility Analyses and Experimental Confirmation of Dove Prism Based Dual-fiberscope Rotary Joint

Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

Posted by klaurent UCSD / Salk

Kavli Affiliate: Samuel Pfaff | Authors: Lydia Daboussi, Giancarlo Costaguta, Miriam Gullo, Veronica Pessino, Brendan O’Leary, Karen Lettieri, Shawn Driscoll and Samuel L. Pfaff | Summary: Abstract Schwann cells respond to acute axon damage by transiently transdifferentiating into specialized repair cells that restore sensorimotor function. However, the molecular systems controlling repair cell formation and function […]


Continue.. Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller | Authors: Han Zhu, Gaowei Wang, Kim-Vy Nguyen-Ngoc, Dongsu Kim, Michael Miller, Georgina Goss, Jenna Kovsky, Austin R Harrington, Diane Saunders, Rebecca Melton, Alvin C Powers, Sebastian Preissl, Francesca M Spagnoli, Kyle J Gaulton and Maike Sander | Summary: Abstract Pancreatic islet cells derived from human pluripotent stem cells hold great […]


Continue.. Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

Ultrastructure of synaptic connectivity within sub-regions of the SCN revealed by genetically encoded EM tag and SBEM

Posted by klaurent UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Hugo Calligaro, Azarin Shoghi, Xinyue Chen, Keun-Young Kim, Yu Hsin Liu, Brian Khov, Benjamin Finander, Hiep Le, Mark H Ellisman and Satchidananda Panda | Summary: Abstract The suprachiasmatic nucleus (SCN) in the hypothalamus of the vertebrate brain is the central pacemaker regulating circadian rhythmicity throughout the body. The SCN […]


Continue.. Ultrastructure of synaptic connectivity within sub-regions of the SCN revealed by genetically encoded EM tag and SBEM

Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells

Posted by klaurent UCSD / Salk

Kavli Affiliate: Fred Gage | Authors: Sarah L Parylak, Fan Qiu, Sara B Linker, Iryna S Gallina, Christina K Lim, David Preciado, Aidan H McDonald and Fred H Gage | Summary: Abstract Immature dentate granule cells (DGCs) generated in the hippocampus during adulthood are believed to play a unique role in dentate gyrus function. Although […]


Continue.. Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells

HNF1α transcriptional activation and repression maintain human islet α and β cell function

Posted by klaurent NTNU

Kavli Affiliate: Vy Thuy Nguyen | Authors: Mollie Friedlander Qian, Romina J Bevacqua, Vy M Nguyen, Xiong Liu, Weichen Zhao, Charles A Chang, Xueying Gu, Xiao-Qing Dai, Patrick E Macdonald and Seung K. Kim | Summary: ABSTRACT HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes (HNF1A-MODY) and hypomorphic HNF1A variants confer type […]


Continue.. HNF1α transcriptional activation and repression maintain human islet α and β cell function

Olfactory neuronal cells: biopsied surrogates for neurons in the brain

Posted by klaurent Hopkins

Kavli Affiliate: Donald Geman, Laurent Younes | Authors: Kun Yang, Koko Ishizuka, Zui Narita, Yukiko Y Lema, Siwei Zhang, Jubao Duan, Laurent Younes, Donald Geman, Andrew P Lane and Akira Sawa | Summary: ABSTRACT Biopsy is an essential procedure of clinical medicine in which we obtain tissues and cells that are supposed to directly reflect […]


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Temporal dynamics of the multi-omic response to endurance exercise training across tissues

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller | Authors: MoTrPAC Study Group, David Amar, Nicole R. Gay, Pierre M. Jean Beltran, Joshua N. Adkins, Jose J. Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Nasim Bararpour, Charles Burant, Clary Clish, Gary Cutter, Surendra Dasari, Courtney Dennis, Charles R. Evans, Facundo M. Fernández, David Gaul, Yongchao Ge, Robert Gerszten, […]


Continue.. Temporal dynamics of the multi-omic response to endurance exercise training across tissues

Visuospatial information foraging describes search behavior in learning latent environmental features

Posted by klaurent Columbia

Kavli Affiliate: C. Daniel Salzman | Authors: David L Barack, Akram Bakkour, Daphna Shohamy and C Daniel Salzman | Summary: Abstract In the real world, making sequences of decisions to achieve goals often depends upon the ability to learn aspects of the environment that are not directly perceptible. Learning these so-called latent features requires seeking […]


Continue.. Visuospatial information foraging describes search behavior in learning latent environmental features