PanIN and CAF Transitions in Pancreatic Carcinogenesis Revealed with Spatial Data Integration

Kavli Affiliate: Denis Wirtz | Authors: Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell, Jacquelyn W Zimmerman, Denis Wirtz, Elizabeth M. Jaffee, Laura D. Wood, Elana J. Fertig and Luciane […]


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The energetics of rapid cellular mechanotransduction

Kavli Affiliate: Michael Young | Authors: Michael N Young, Michael J Sindoni, Amanda H Lewis, Stefan Zauscher and Jorg Grandl | Summary: Cells throughout the human body detect mechanical forces. While it is known that the rapid (millisecond) detection of mechanical forces is mediated by force-gated ion channels, a detailed quantitative understanding of cells as […]


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Thalamus sends information about arousal but not valence to the amygdala

Kavli Affiliate: Kay Tye | Authors: Chris A Leppla, Laurel Keyes, Gordon Glober, Gillian A Matthews, Kanha Batra, Maya Jay, Yu Feng, Hannah S Chen, Fergil Mills, Jeremy Delahanty, Jake Olsen, Edward H Nieh, Praneeth Namburi, Craig Wildes, Romy Wichmann, Anna Beyelar, Eyal Y Kimchi and Kay M. Tye | Summary: Rationale The basolateral amygdala […]


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Spatial transcriptomics of FFPE pancreatic intraepithelial neoplasias reveals cellular and molecular alterations of progression to pancreatic ductal carcinoma

Kavli Affiliate: Denis Wirtz | Authors: Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell, Jacquelyn W Zimmerman, Denis Wirtz, Elizabeth M. Jaffee, Laura D. Wood, Elana J. Fertig and Luciane […]


Continue.. Spatial transcriptomics of FFPE pancreatic intraepithelial neoplasias reveals cellular and molecular alterations of progression to pancreatic ductal carcinoma

Engineered Adhesion Molecules Drive Synapse Organization

Kavli Affiliate: Richard Huganir | Authors: William Dylan Hale, Thomas C. Sudhof and Richard L. Huganir | Summary: In multicellular organisms, cell-adhesion molecules connect cells into tissues and mediate intercellular signaling between these cells. In vertebrate brains, synaptic cell-adhesion molecules (SAMs) guide the formation, specification, and plasticity of synapses. Some SAMs, when overexpressed in cultured […]


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Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys

Kavli Affiliate: John Reynolds, Kenneth Miller | Authors: Alessandro Sanzeni, Agostina Palmigiano, Tuan H Nguyen, Junxiang Luo, Jonathan J Nassi, John H Reynolds, Mark H Histed, Kenneth D Miller and Nicolas Brunel | Summary: The ability to observe the response of neural circuits to controlled optogenetic perturbations opens an unprecedented window into the mechanisms governing […]


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Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii

Kavli Affiliate: John Carlson | Authors: Wanyue Wang, Hany K M Dweck, Gaëlle J.S. Talross, Ali Zaidi, Joshua M Gendron and John R Carlson | Summary: The agricultural pest Drosophila suzukii differs from most other Drosophila species in that it lays eggs in ripe, rather than overripe, fruit. Previously we showed that changes in bitter […]


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Rewiring Dynamics of Functional Connectome in Motor Cortex during Motor Skill Learning

Kavli Affiliate: Takaki Komiyama | Authors: Saber Meamardoost, Eunjung Hwang, Mahasweta Bhattacharya, Chi Ren, Linbing Wang, Claudia Mewes, Ying Zhang, Takaki Komiyama and Rudiyanto Gunawan | Summary: The brain’s connectome continually rewires throughout the life of an organism. In this study, we sought to elucidate the operational principles of such rewiring by analyzing the functional […]


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The spatial distribution and temporal trends of livestock damages caused by wolves in Europe

Kavli Affiliate: Jose Suarez Lopez | Authors: Liam Singer, Xenia Wietlisbach, Raffael Hickisch, Eva Maria Schoell, Angela Van den Broek, Manon Désalme, Koen Driesen, Mari Lyly, Francesca Marucco, Miroslav Kutal, Nives Pagon, Cristian Remus Papp, Paraskevi Milioni, Remigijus Uzdras, Ilgvars Zihmanis, Fridolin Zimmermann, Katrina Marsden, Klaus Hackländer, José Vicente López-Bao, Sybille Klenzendorf and Daniel Wegmann […]


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Pulsatile electrical stimulation creates predictable, correctable disruptions in neural firing

Kavli Affiliate: Kathleen Cullen | Authors: Cynthia R Steinhardt, Diana E Mitchell, Kathleen E Cullen and Gene Y Fridman | Summary: Electrical stimulation of neural responses is used both scientifically in brain mapping studies and in many clinical applications such as cochlear, vestibular, and retinal implants. Due to safety considerations, stimulation of the nervous system […]


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