Hierarchical Deviant Processing in Auditory Cortex of Awake Mice

Kavli Affiliate: Patrick Kanold | Authors: Dan Luo, Ji Liu, Ryszard Auksztulewicz, Tony Ka Wing Yip, Patrick O. Kanold and Jan W. Schnupp | Summary: Detecting patterns, and noticing unexpected pattern changes, in the environment is a vital aspect of sensory processing. Adaptation and prediction error responses are two components of neural processing related to […]


Continue.. Hierarchical Deviant Processing in Auditory Cortex of Awake Mice

Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes

Kavli Affiliate: Saul Kato | Authors: Morgan M Stanton, Sara Modan, Patrick M Taylor, Harsh N Hariani, Jordan Sorokin, Brian G Rash, Sneha B Rao, Alejandro Lopez-Tobon, Luigi Enriquez, Brenda Dang, Dorah Owango, Shannon O’Neill, Carlos Castrillo, Justin Nicola, Kathy Ye, Robert M Blattner, Federico Gonzalez, Dexter Antonio, Pavan Ramkumar, Andy Lash, Douglas Flanzer, Sophia […]


Continue.. Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes

Hippocampal area CA2 controls seizure dynamics, interictal EEG abnormalities and social comorbidity in mouse models of temporal lobe epilepsy

Kavli Affiliate: Steven Siegelbaum | Authors: Christos Panagiotis Lisgaras, Azahara Oliva, Sam Mckenzie, John LaFrancois, Steven A. Siegelbaum and Helen E. Scharman | Summary: Temporal lobe epilepsy (TLE) is characterized by spontaneous recurrent seizures, abnormal activity between seizures, and impaired behavior. CA2 pyramidal neurons (PNs) are potentially important because inhibiting them with a chemogenetic approach […]


Continue.. Hippocampal area CA2 controls seizure dynamics, interictal EEG abnormalities and social comorbidity in mouse models of temporal lobe epilepsy

EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

Kavli Affiliate: Jose Suarez Lopez | Authors: Sukanya Chakraborty, Aaqib M. Bhat, Insha Mushtaq, Haitao Luan, Achyuth Kalluchi, Sameer Mirza, Matthew D. Storck, Nagendra Chaturvedi, Jose Antonio Lopez-Guerreo, Antonio Llombart-Bosch, Isidro Machado, Jane L. Meza, Gargi Ghosal, Donald W. Coulter, Jordan M. Rowley, Vimla Band, Bhopal C. Mohapatra and Hamid Band | Summary: We previously […]


Continue.. EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels

Kavli Affiliate: Michael Keiser | Authors: Daniel R. Wong, Shino D. Magaki, Harry V. Vinters, William H. Yong, Edwin S. Monuki, Christopher K. Williams, Alessandra C. Martini, Charles DeCarli, Chris Khacherian, John P. Graff, Brittany N. Dugger and Michael J. Keiser | Summary: Precise, scalable, and quantitative evaluation of whole slide images is crucial in […]


Continue.. Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels

Grapevine scion gene expression is driven by rootstock and environment interaction

Kavli Affiliate: Angela Wu | Authors: Zachary N Harris, Julia E Pratt, Laszlo G Kovacs, Laura L Klein, Misha T Kwasniewski, Jason P Londo, Angela Wu and Allison J Miller | Summary: BACKGROUND Grafting is a horticultural practice used widely across woody perennial crop species to fuse together the root and shoot system of two […]


Continue.. Grapevine scion gene expression is driven by rootstock and environment interaction

The neural activity of auditory conscious perception

Kavli Affiliate: Hal Blumenfeld | Authors: Kate L. Christison-Lagay, Noah C. Freedman, Christopher Micek, Aya Khalaf, Sharif I. Kronemer, Mariana M. Gusso, Lauren Kim, Sarit Forman, Julia Ding, Mark Aksen, Ahmad Abdel-Aty, Hunki Kwon, Noah Markowitz, Erin Yeagle, Elizabeth Espinal, Jose Herrero, Stephan Bickel, James Young, Ashesh Mehta, Kun Wu, Jason Gerrard, Eyiyemisi Damisah, Dennis […]


Continue.. The neural activity of auditory conscious perception

End Binding protein 1 promotes specific motor-cargo association in the cell body prior to axonal delivery of Dense Core Vesicles

Kavli Affiliate: Pietro DeCamilli, Kenneth Miller | Authors: Junhyun Park, Kenneth G. Miller, Pietro De Camilli and Shaul Yogev | Summary: Axonal transport is key to neuronal function. Efficient transport requires specific motor-cargo association in the soma, yet the mechanisms regulating this early step remain poorly understood. We found that EBP-1, the C. elegans ortholog […]


Continue.. End Binding protein 1 promotes specific motor-cargo association in the cell body prior to axonal delivery of Dense Core Vesicles

Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

Kavli Affiliate: Jeremy Nathans | Authors: Jie Wang, Amir Rattner and Jeremy Nathans | Summary: Bacterial meningitis is a major cause of morbidity and mortality, especially among infants and the elderly. Here we study mice to assess the response of each of the major meningeal cell types to early postnatal E. coli infection using single […]


Continue.. Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

Low Rate Hippocampal Delay Period Activity Encodes Behavioral Experience

Kavli Affiliate: Jill Leutgeb | Authors: Markos Athanasiadis, Stefano Masserini, Li Yuan, Dustin Fetterhoff, Jill K Leutgeb, Stefan Leutgeb and Christian Leibold | Summary: Remembering what just happened is a crucial prerequisite to form long-term memories but also for establishing and maintaining working memory. So far there is no general agreement about cortical mechanisms that […]


Continue.. Low Rate Hippocampal Delay Period Activity Encodes Behavioral Experience